The Predictive Value of Time-Varying Noninvasive Scores on Long-Term Prognosis of NAFLD in South Korea
Background. This study aimed to examine whether repeated measurements on noninvasive fibrosis scores during follow-up improve long-term nonalcoholic fatty liver disease (NAFLD) outcome prediction. Methods. A cohort study of 2,280 NAFLD patients diagnosed at the Seoul National University Hospital fro...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2024/5667986 |
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| author | Sung Won Chung Min Kyung Park Xiao Zhang Tongtong Wang Thomas Jemielita Gail Fernandes Samuel S. Engel Heejoon Jang Yun Bin Lee Eun Ju Cho Jeong-Hoon Lee Su Jong Yu Jung-Hwan Yoon Yoon Jun Kim |
| author_facet | Sung Won Chung Min Kyung Park Xiao Zhang Tongtong Wang Thomas Jemielita Gail Fernandes Samuel S. Engel Heejoon Jang Yun Bin Lee Eun Ju Cho Jeong-Hoon Lee Su Jong Yu Jung-Hwan Yoon Yoon Jun Kim |
| author_sort | Sung Won Chung |
| collection | DOAJ |
| description | Background. This study aimed to examine whether repeated measurements on noninvasive fibrosis scores during follow-up improve long-term nonalcoholic fatty liver disease (NAFLD) outcome prediction. Methods. A cohort study of 2,280 NAFLD patients diagnosed at the Seoul National University Hospital from 2001 to 2015 was conducted. Multivariable Cox regression models with baseline and designated time-point measurements of the fibrosis-4 index (FIB-4) and NAFLD fibrosis score (NFS) were used to assess the association between these scores and overall mortality, liver-related outcomes, and cardiovascular events. Results. Higher baseline NFS (high versus low probability for advanced fibrosis groups) was associated with higher risk of mortality (adjusted hazard ratio (aHR), (95% confidence interval (CI)), 2.80, [1.39–5.63]) and liver-related outcomes (3.70, [1.27–10.78]). Similar findings were observed for the association of baseline FIB-4 with mortality (2.49, [1.46–4.24]) and liver-related outcomes (11.50, [6.17–21.44]). In models considering designated time-point measurements of the scores, stronger associations were noted. For NFS, a higher time-point measurement was associated with a significantly higher risk of mortality (3.01, [1.65–5.49]) and liver-related outcomes (6.69, [2.62–17.06]). For FIB-4, higher time-point measurements were associated with significantly higher mortality (3.01, [1.88–4.82]) and liver-related outcomes (13.26, [6.89–25.53]). An annual increase in FIB-4 (2.70, [1.79–4.05]) or NFS (4.68, [1.52–14.44]) was associated with an increased risk of liver-related outcomes. No association between NFS/FIB-4 and risk of cardiovascular events was observed in both models. Conclusions. Higher aHRs describing the associations of FIB-4/NFS with overall mortality and liver-related outcomes were observed in the models that included designated time-point measurements of the scores. In addition to the baseline measurement, a routine monitoring on these scores may be important in predicting prognosis of NAFLD patients. |
| format | Article |
| id | doaj-art-321a97274d614b0097022e48eba50aa9 |
| institution | Kabale University |
| issn | 2291-2797 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-321a97274d614b0097022e48eba50aa92025-02-03T11:08:00ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27972024-01-01202410.1155/2024/5667986The Predictive Value of Time-Varying Noninvasive Scores on Long-Term Prognosis of NAFLD in South KoreaSung Won Chung0Min Kyung Park1Xiao Zhang2Tongtong Wang3Thomas Jemielita4Gail Fernandes5Samuel S. Engel6Heejoon Jang7Yun Bin Lee8Eun Ju Cho9Jeong-Hoon Lee10Su Jong Yu11Jung-Hwan Yoon12Yoon Jun Kim13Department of Internal Medicine and Liver Research InstituteDepartment of Internal Medicine and Liver Research InstituteMerck & Co., Inc.Merck & Co., Inc.Merck & Co., Inc.Merck & Co., Inc.Merck & Co., Inc.Department of Internal Medicine and Liver Research InstituteDepartment of Internal Medicine and Liver Research InstituteDepartment of Internal Medicine and Liver Research InstituteDepartment of Internal Medicine and Liver Research InstituteDepartment of Internal Medicine and Liver Research InstituteDepartment of Internal Medicine and Liver Research InstituteDepartment of Internal Medicine and Liver Research InstituteBackground. This study aimed to examine whether repeated measurements on noninvasive fibrosis scores during follow-up improve long-term nonalcoholic fatty liver disease (NAFLD) outcome prediction. Methods. A cohort study of 2,280 NAFLD patients diagnosed at the Seoul National University Hospital from 2001 to 2015 was conducted. Multivariable Cox regression models with baseline and designated time-point measurements of the fibrosis-4 index (FIB-4) and NAFLD fibrosis score (NFS) were used to assess the association between these scores and overall mortality, liver-related outcomes, and cardiovascular events. Results. Higher baseline NFS (high versus low probability for advanced fibrosis groups) was associated with higher risk of mortality (adjusted hazard ratio (aHR), (95% confidence interval (CI)), 2.80, [1.39–5.63]) and liver-related outcomes (3.70, [1.27–10.78]). Similar findings were observed for the association of baseline FIB-4 with mortality (2.49, [1.46–4.24]) and liver-related outcomes (11.50, [6.17–21.44]). In models considering designated time-point measurements of the scores, stronger associations were noted. For NFS, a higher time-point measurement was associated with a significantly higher risk of mortality (3.01, [1.65–5.49]) and liver-related outcomes (6.69, [2.62–17.06]). For FIB-4, higher time-point measurements were associated with significantly higher mortality (3.01, [1.88–4.82]) and liver-related outcomes (13.26, [6.89–25.53]). An annual increase in FIB-4 (2.70, [1.79–4.05]) or NFS (4.68, [1.52–14.44]) was associated with an increased risk of liver-related outcomes. No association between NFS/FIB-4 and risk of cardiovascular events was observed in both models. Conclusions. Higher aHRs describing the associations of FIB-4/NFS with overall mortality and liver-related outcomes were observed in the models that included designated time-point measurements of the scores. In addition to the baseline measurement, a routine monitoring on these scores may be important in predicting prognosis of NAFLD patients.http://dx.doi.org/10.1155/2024/5667986 |
| spellingShingle | Sung Won Chung Min Kyung Park Xiao Zhang Tongtong Wang Thomas Jemielita Gail Fernandes Samuel S. Engel Heejoon Jang Yun Bin Lee Eun Ju Cho Jeong-Hoon Lee Su Jong Yu Jung-Hwan Yoon Yoon Jun Kim The Predictive Value of Time-Varying Noninvasive Scores on Long-Term Prognosis of NAFLD in South Korea Canadian Journal of Gastroenterology and Hepatology |
| title | The Predictive Value of Time-Varying Noninvasive Scores on Long-Term Prognosis of NAFLD in South Korea |
| title_full | The Predictive Value of Time-Varying Noninvasive Scores on Long-Term Prognosis of NAFLD in South Korea |
| title_fullStr | The Predictive Value of Time-Varying Noninvasive Scores on Long-Term Prognosis of NAFLD in South Korea |
| title_full_unstemmed | The Predictive Value of Time-Varying Noninvasive Scores on Long-Term Prognosis of NAFLD in South Korea |
| title_short | The Predictive Value of Time-Varying Noninvasive Scores on Long-Term Prognosis of NAFLD in South Korea |
| title_sort | predictive value of time varying noninvasive scores on long term prognosis of nafld in south korea |
| url | http://dx.doi.org/10.1155/2024/5667986 |
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