Synthesis and Evaluation of Some Coumarin Containing Potential Antimicrobial Agents
A series of the Schiff’s bases incorporating coumarin and chalcone moeities, 3-(4-(4-(substituted phenyl)prop-1-ene-3-one) phenylimino) methyl)-4-chloro-2h-chromen-2-one 4(a-g) were synthesized as potential antimicrobial agents. These compounds were characterized on the basis of their spectral (IR,...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/953564 |
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| author | Sayali D. Kudale Meenakshi N. Deodhar |
| author_facet | Sayali D. Kudale Meenakshi N. Deodhar |
| author_sort | Sayali D. Kudale |
| collection | DOAJ |
| description | A series of the Schiff’s bases incorporating coumarin and chalcone moeities, 3-(4-(4-(substituted phenyl)prop-1-ene-3-one) phenylimino) methyl)-4-chloro-2h-chromen-2-one 4(a-g) were synthesized as potential antimicrobial agents. These compounds were characterized on the basis of their spectral (IR, 1H NMR) data and evaluated for antimicrobial activity in vitro against gram positive and gram negative bacteria and fungi. Compound 4b was found to be most active with an MIC of 20 µg/mL against all the tested organisms. |
| format | Article |
| id | doaj-art-32179f03a7c64fde85ee672225411cad |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-32179f03a7c64fde85ee672225411cad2025-02-03T01:31:10ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-01942493250010.1155/2012/953564Synthesis and Evaluation of Some Coumarin Containing Potential Antimicrobial AgentsSayali D. Kudale0Meenakshi N. Deodhar1Department of Pharmaceutical Chemistry, Pdea's Seth Govind Raghunath, Sable College of Pharmacy, Saswad, Pune-412301, IndiaDepartment of Pharmaceutical Chemistry, Pdea's Seth Govind Raghunath, Sable College of Pharmacy, Saswad, Pune-412301, IndiaA series of the Schiff’s bases incorporating coumarin and chalcone moeities, 3-(4-(4-(substituted phenyl)prop-1-ene-3-one) phenylimino) methyl)-4-chloro-2h-chromen-2-one 4(a-g) were synthesized as potential antimicrobial agents. These compounds were characterized on the basis of their spectral (IR, 1H NMR) data and evaluated for antimicrobial activity in vitro against gram positive and gram negative bacteria and fungi. Compound 4b was found to be most active with an MIC of 20 µg/mL against all the tested organisms.http://dx.doi.org/10.1155/2012/953564 |
| spellingShingle | Sayali D. Kudale Meenakshi N. Deodhar Synthesis and Evaluation of Some Coumarin Containing Potential Antimicrobial Agents E-Journal of Chemistry |
| title | Synthesis and Evaluation of Some Coumarin Containing Potential Antimicrobial Agents |
| title_full | Synthesis and Evaluation of Some Coumarin Containing Potential Antimicrobial Agents |
| title_fullStr | Synthesis and Evaluation of Some Coumarin Containing Potential Antimicrobial Agents |
| title_full_unstemmed | Synthesis and Evaluation of Some Coumarin Containing Potential Antimicrobial Agents |
| title_short | Synthesis and Evaluation of Some Coumarin Containing Potential Antimicrobial Agents |
| title_sort | synthesis and evaluation of some coumarin containing potential antimicrobial agents |
| url | http://dx.doi.org/10.1155/2012/953564 |
| work_keys_str_mv | AT sayalidkudale synthesisandevaluationofsomecoumarincontainingpotentialantimicrobialagents AT meenakshindeodhar synthesisandevaluationofsomecoumarincontainingpotentialantimicrobialagents |