Temporal Effects of Disease Signature Genes and Core Mechanisms in the Hyperacute Phase of Acute Ischemic Stroke: A Bioinformatics Analysis and Experimental Validation
Conclusion: This study systematically identifies hyperacute-phase-specific biomarkers in AIS and delineates their temporal regulatory logic. The time-course dynamics of neuronal apoptosis and inflammatory regulation in the hyperacute phase of AIS were monitored. The observed biphasic apoptotic patte...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/mi/6808184 |
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| _version_ | 1849335828655898624 |
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| author | Peng-Li Ding Kai-Xin Zhang Fang Yao Wen-Qiang Cui Zhen-Ling Liu Yi-Ran Wang Xiang-Ying Wang Wei Liu Heng-Ye Zhao Hong-Yun Wu Ya-Han Wang Xiang-Qing Xu |
| author_facet | Peng-Li Ding Kai-Xin Zhang Fang Yao Wen-Qiang Cui Zhen-Ling Liu Yi-Ran Wang Xiang-Ying Wang Wei Liu Heng-Ye Zhao Hong-Yun Wu Ya-Han Wang Xiang-Qing Xu |
| author_sort | Peng-Li Ding |
| collection | DOAJ |
| description | Conclusion: This study systematically identifies hyperacute-phase-specific biomarkers in AIS and delineates their temporal regulatory logic. The time-course dynamics of neuronal apoptosis and inflammatory regulation in the hyperacute phase of AIS were monitored. The observed biphasic apoptotic pattern provides mechanistic insights for developing chronologically targeted therapies, such as timed inhibition of TLR4/CD86 during 0–3 h to block inflammatory initiation, or administration of Agpat1 agonists at 3–6 h to stabilize mitochondrial function. These findings help alleviate the current ‘molecular blind spot’ in early stroke diagnosis and intervention. |
| format | Article |
| id | doaj-art-3215698b7de147ee9b2683d698f2bbd2 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3215698b7de147ee9b2683d698f2bbd22025-08-20T03:45:10ZengWileyMediators of Inflammation1466-18612025-01-01202510.1155/mi/6808184Temporal Effects of Disease Signature Genes and Core Mechanisms in the Hyperacute Phase of Acute Ischemic Stroke: A Bioinformatics Analysis and Experimental ValidationPeng-Li Ding0Kai-Xin Zhang1Fang Yao2Wen-Qiang Cui3Zhen-Ling Liu4Yi-Ran Wang5Xiang-Ying Wang6Wei Liu7Heng-Ye Zhao8Hong-Yun Wu9Ya-Han Wang10Xiang-Qing Xu11First College of Clinical MedicineFirst College of Clinical MedicineNursing DepartmentNeurology DepartmentFirst College of Clinical MedicineFirst College of Clinical MedicineFirst College of Clinical MedicineFirst College of Clinical MedicineFirst College of Clinical MedicineNeurology DepartmentDepartment of NeurologyNeurology DepartmentConclusion: This study systematically identifies hyperacute-phase-specific biomarkers in AIS and delineates their temporal regulatory logic. The time-course dynamics of neuronal apoptosis and inflammatory regulation in the hyperacute phase of AIS were monitored. The observed biphasic apoptotic pattern provides mechanistic insights for developing chronologically targeted therapies, such as timed inhibition of TLR4/CD86 during 0–3 h to block inflammatory initiation, or administration of Agpat1 agonists at 3–6 h to stabilize mitochondrial function. These findings help alleviate the current ‘molecular blind spot’ in early stroke diagnosis and intervention.http://dx.doi.org/10.1155/mi/6808184 |
| spellingShingle | Peng-Li Ding Kai-Xin Zhang Fang Yao Wen-Qiang Cui Zhen-Ling Liu Yi-Ran Wang Xiang-Ying Wang Wei Liu Heng-Ye Zhao Hong-Yun Wu Ya-Han Wang Xiang-Qing Xu Temporal Effects of Disease Signature Genes and Core Mechanisms in the Hyperacute Phase of Acute Ischemic Stroke: A Bioinformatics Analysis and Experimental Validation Mediators of Inflammation |
| title | Temporal Effects of Disease Signature Genes and Core Mechanisms in the Hyperacute Phase of Acute Ischemic Stroke: A Bioinformatics Analysis and Experimental Validation |
| title_full | Temporal Effects of Disease Signature Genes and Core Mechanisms in the Hyperacute Phase of Acute Ischemic Stroke: A Bioinformatics Analysis and Experimental Validation |
| title_fullStr | Temporal Effects of Disease Signature Genes and Core Mechanisms in the Hyperacute Phase of Acute Ischemic Stroke: A Bioinformatics Analysis and Experimental Validation |
| title_full_unstemmed | Temporal Effects of Disease Signature Genes and Core Mechanisms in the Hyperacute Phase of Acute Ischemic Stroke: A Bioinformatics Analysis and Experimental Validation |
| title_short | Temporal Effects of Disease Signature Genes and Core Mechanisms in the Hyperacute Phase of Acute Ischemic Stroke: A Bioinformatics Analysis and Experimental Validation |
| title_sort | temporal effects of disease signature genes and core mechanisms in the hyperacute phase of acute ischemic stroke a bioinformatics analysis and experimental validation |
| url | http://dx.doi.org/10.1155/mi/6808184 |
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