Implementation of negative pressure for acute pediatric burns (INPREP): A stepped-wedge cluster randomized controlled trial protocol.
<h4>Background</h4>Acute application of adjunctive negative pressure wound therapy (NPWT) significantly improves time to re-epithelialization in pediatric burn patients. This adjunctive treatment has not yet been broadly or routinely adopted as a standard primary burns dressing strategy....
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0315278 |
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| author | Maleea D Holbert Fiona Wood Andrew J A Holland Warwick Teague Roy M Kimble Dianne Crellin Cody C Frear Kristen Storey Natalie Phillips Yvonne Singer Tanesha A Dimanopoulos Lisa Martin Leila Cuttle Dimitrios Vagenas Steven M McPhail Pauline Calleja Jed Duff Alexandra De Young Bronwyn R Griffin |
| author_facet | Maleea D Holbert Fiona Wood Andrew J A Holland Warwick Teague Roy M Kimble Dianne Crellin Cody C Frear Kristen Storey Natalie Phillips Yvonne Singer Tanesha A Dimanopoulos Lisa Martin Leila Cuttle Dimitrios Vagenas Steven M McPhail Pauline Calleja Jed Duff Alexandra De Young Bronwyn R Griffin |
| author_sort | Maleea D Holbert |
| collection | DOAJ |
| description | <h4>Background</h4>Acute application of adjunctive negative pressure wound therapy (NPWT) significantly improves time to re-epithelialization in pediatric burn patients. This adjunctive treatment has not yet been broadly or routinely adopted as a standard primary burns dressing strategy. The Implementation of Negative PRessurE for acute Pediatric burns (INPREP) trial will implement and evaluate the impact of adjunctive NPWT in parallel with co-designed implementation strategies and resources across four major pediatric hospitals.<h4>Methods</h4>We will conduct a multi-center, prospective, stepped-wedge cluster randomized controlled trial to implement adjunctive NPWT for acute pediatric burns. Participants will include pediatric burn patients presenting to one of four Australian tertiary pediatric hospitals for burn treatment. The intervention is adjunctive NPWT in parallel with co-designed and tailored implementation strategies and a suite of NPWT implementation resources, which form the INPREP toolkit. Using a hybrid type III design, this trial aims to evaluate the effectiveness of NPWT implementation in parallel with the INPREP toolkit using (i) implementation outcomes (e.g., adoption, appropriateness, acceptability, feasibility, and sustainability) and (ii) clinical outcomes (e.g., days to re-epithelialization, scar management requirements, skin grafting requirements). The primary outcome of this trial is treatment adoption-the proportion of eligible patients who receive NPWT.<h4>Discussion</h4>This manuscript outlines a protocol for a hybrid type III stepped-wedge cluster randomized controlled trial of adjunctive NPWT implementation in acute pediatric burn care. We anticipate that NPWT implementation in parallel with the INPREP toolkit will be generalizable to emergency departments and burn services across Australia, and evidence generated will inform pediatric burn care internationally.<h4>Trial registration</h4>Australian and New Zealand Clinical Trials Registry: ACTRN12622000166774. Registered 1 February 2022. |
| format | Article |
| id | doaj-art-3214f65c66bc4cb59a3e768b0a7b9fdd |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-3214f65c66bc4cb59a3e768b0a7b9fdd2025-08-20T02:39:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-011912e031527810.1371/journal.pone.0315278Implementation of negative pressure for acute pediatric burns (INPREP): A stepped-wedge cluster randomized controlled trial protocol.Maleea D HolbertFiona WoodAndrew J A HollandWarwick TeagueRoy M KimbleDianne CrellinCody C FrearKristen StoreyNatalie PhillipsYvonne SingerTanesha A DimanopoulosLisa MartinLeila CuttleDimitrios VagenasSteven M McPhailPauline CallejaJed DuffAlexandra De YoungBronwyn R Griffin<h4>Background</h4>Acute application of adjunctive negative pressure wound therapy (NPWT) significantly improves time to re-epithelialization in pediatric burn patients. This adjunctive treatment has not yet been broadly or routinely adopted as a standard primary burns dressing strategy. The Implementation of Negative PRessurE for acute Pediatric burns (INPREP) trial will implement and evaluate the impact of adjunctive NPWT in parallel with co-designed implementation strategies and resources across four major pediatric hospitals.<h4>Methods</h4>We will conduct a multi-center, prospective, stepped-wedge cluster randomized controlled trial to implement adjunctive NPWT for acute pediatric burns. Participants will include pediatric burn patients presenting to one of four Australian tertiary pediatric hospitals for burn treatment. The intervention is adjunctive NPWT in parallel with co-designed and tailored implementation strategies and a suite of NPWT implementation resources, which form the INPREP toolkit. Using a hybrid type III design, this trial aims to evaluate the effectiveness of NPWT implementation in parallel with the INPREP toolkit using (i) implementation outcomes (e.g., adoption, appropriateness, acceptability, feasibility, and sustainability) and (ii) clinical outcomes (e.g., days to re-epithelialization, scar management requirements, skin grafting requirements). The primary outcome of this trial is treatment adoption-the proportion of eligible patients who receive NPWT.<h4>Discussion</h4>This manuscript outlines a protocol for a hybrid type III stepped-wedge cluster randomized controlled trial of adjunctive NPWT implementation in acute pediatric burn care. We anticipate that NPWT implementation in parallel with the INPREP toolkit will be generalizable to emergency departments and burn services across Australia, and evidence generated will inform pediatric burn care internationally.<h4>Trial registration</h4>Australian and New Zealand Clinical Trials Registry: ACTRN12622000166774. Registered 1 February 2022.https://doi.org/10.1371/journal.pone.0315278 |
| spellingShingle | Maleea D Holbert Fiona Wood Andrew J A Holland Warwick Teague Roy M Kimble Dianne Crellin Cody C Frear Kristen Storey Natalie Phillips Yvonne Singer Tanesha A Dimanopoulos Lisa Martin Leila Cuttle Dimitrios Vagenas Steven M McPhail Pauline Calleja Jed Duff Alexandra De Young Bronwyn R Griffin Implementation of negative pressure for acute pediatric burns (INPREP): A stepped-wedge cluster randomized controlled trial protocol. PLoS ONE |
| title | Implementation of negative pressure for acute pediatric burns (INPREP): A stepped-wedge cluster randomized controlled trial protocol. |
| title_full | Implementation of negative pressure for acute pediatric burns (INPREP): A stepped-wedge cluster randomized controlled trial protocol. |
| title_fullStr | Implementation of negative pressure for acute pediatric burns (INPREP): A stepped-wedge cluster randomized controlled trial protocol. |
| title_full_unstemmed | Implementation of negative pressure for acute pediatric burns (INPREP): A stepped-wedge cluster randomized controlled trial protocol. |
| title_short | Implementation of negative pressure for acute pediatric burns (INPREP): A stepped-wedge cluster randomized controlled trial protocol. |
| title_sort | implementation of negative pressure for acute pediatric burns inprep a stepped wedge cluster randomized controlled trial protocol |
| url | https://doi.org/10.1371/journal.pone.0315278 |
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