Effect of Ageing on Systemic Inflammatory Response in Acute Pancreatitis
Elderly patients show increased incidence of multiple organ dysfunction in acute pancreatitis possibly due to bacterial translocation. This is associated with increased susceptibility to infections in older people. Several reports have related this increased susceptibility to a proinflammatory statu...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/270319 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850218660123115520 |
|---|---|
| author | Marcel Cerqueira Cesar Machado Ana Maria Mendonça Coelho Luiz Augusto Carneiro D’Albuquerque Sonia Jancar |
| author_facet | Marcel Cerqueira Cesar Machado Ana Maria Mendonça Coelho Luiz Augusto Carneiro D’Albuquerque Sonia Jancar |
| author_sort | Marcel Cerqueira Cesar Machado |
| collection | DOAJ |
| description | Elderly patients show increased incidence of multiple organ dysfunction in acute pancreatitis possibly due to bacterial translocation. This is associated with increased susceptibility to infections in older people. Several reports have related this increased susceptibility to a proinflammatory status called inflammaging, which decreases the capacity of the immunological system to respond to antigens. Cellular senescence also contributes to this low-grade chronic inflammation in older subjects. We discuss here the effect of ageing on systemic inflammation, focusing on that induced by acute pancreatitis and some of the mechanisms involved. It is important to understand the immunological changes in the elderly to adjust treatment strategies in order to reduce the morbidity and mortality associated with acute pancreatitis and other conditions that lead to systemic inflammation. |
| format | Article |
| id | doaj-art-3210a410f6fe43d99ea3d9e9373bb490 |
| institution | OA Journals |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-3210a410f6fe43d99ea3d9e9373bb4902025-08-20T02:07:39ZengWileyInternational Journal of Inflammation2090-80402042-00992012-01-01201210.1155/2012/270319270319Effect of Ageing on Systemic Inflammatory Response in Acute PancreatitisMarcel Cerqueira Cesar Machado0Ana Maria Mendonça Coelho1Luiz Augusto Carneiro D’Albuquerque2Sonia Jancar3LIM-37, Department of Gastroenterology, University of Sao Paulo Medical School, 01246-903 Sao Paulo, SP, BrazilLIM-37, Department of Gastroenterology, University of Sao Paulo Medical School, 01246-903 Sao Paulo, SP, BrazilLIM-37, Department of Gastroenterology, University of Sao Paulo Medical School, 01246-903 Sao Paulo, SP, BrazilDepartment of Immunology, Institute for Biomedical Sciences, University of Sao Paulo, 05508-900 Sao Paulo, SP, BrazilElderly patients show increased incidence of multiple organ dysfunction in acute pancreatitis possibly due to bacterial translocation. This is associated with increased susceptibility to infections in older people. Several reports have related this increased susceptibility to a proinflammatory status called inflammaging, which decreases the capacity of the immunological system to respond to antigens. Cellular senescence also contributes to this low-grade chronic inflammation in older subjects. We discuss here the effect of ageing on systemic inflammation, focusing on that induced by acute pancreatitis and some of the mechanisms involved. It is important to understand the immunological changes in the elderly to adjust treatment strategies in order to reduce the morbidity and mortality associated with acute pancreatitis and other conditions that lead to systemic inflammation.http://dx.doi.org/10.1155/2012/270319 |
| spellingShingle | Marcel Cerqueira Cesar Machado Ana Maria Mendonça Coelho Luiz Augusto Carneiro D’Albuquerque Sonia Jancar Effect of Ageing on Systemic Inflammatory Response in Acute Pancreatitis International Journal of Inflammation |
| title | Effect of Ageing on Systemic Inflammatory Response in Acute Pancreatitis |
| title_full | Effect of Ageing on Systemic Inflammatory Response in Acute Pancreatitis |
| title_fullStr | Effect of Ageing on Systemic Inflammatory Response in Acute Pancreatitis |
| title_full_unstemmed | Effect of Ageing on Systemic Inflammatory Response in Acute Pancreatitis |
| title_short | Effect of Ageing on Systemic Inflammatory Response in Acute Pancreatitis |
| title_sort | effect of ageing on systemic inflammatory response in acute pancreatitis |
| url | http://dx.doi.org/10.1155/2012/270319 |
| work_keys_str_mv | AT marcelcerqueiracesarmachado effectofageingonsystemicinflammatoryresponseinacutepancreatitis AT anamariamendoncacoelho effectofageingonsystemicinflammatoryresponseinacutepancreatitis AT luizaugustocarneirodalbuquerque effectofageingonsystemicinflammatoryresponseinacutepancreatitis AT soniajancar effectofageingonsystemicinflammatoryresponseinacutepancreatitis |