Thioredoxin related transmembrane protein 1acts as a prognostic indictor and promotes proliferation and TMZ resistance of lower-grade glioma

Thioredoxin related transmembrane protein 1acts as a prognostic indictor and promotes proliferation and TMZ resistance of lower-grade glioma

Abstract Thioredoxin Related Transmembrane Protein 1 (TMX1) encodes a thiol-disulfide oxidoreductase and regulates cleavage, formation, or isomerization of disulfide bonds among cysteine residues in proteins. Using bioinformatic analysis, we firstly prove TMX1 is significantly upregulated in lower-g...

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Bibliographic Details
Main Authors: Hongyan Hui, Fang Zhou, Sujuan Pei, Wenyan Zhou, Jie Shang, Pengwei Wang, Zhijian Deng, Xiang Zhou
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Lower grade glioma (LGG)
Thioredoxin related transmembrane protein 1 (TMX1)
Temozolomide resistance
Cell proliferation
Online Access:https://doi.org/10.1038/s41598-025-89908-y
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