Hypertension-gut microbiota research trends: a bibliometric and visualization analysis (2000–2025)
BackgroundHypertension is a major global public health challenge affecting over 1.3 billion people. Emerging evidence indicates that gut microbiota regulates blood pressure through metabolic and immune-inflammatory pathways. This provides novel insights into hypertension mechanisms and facilitates t...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1543258/full |
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| author | Qilin Chen Qilin Chen Qilin Chen Qilin Chen Chunzhen Ren Chunzhen Ren Chunzhen Ren Chang Shu Chang Shu Chang Shu Xue Yang Hugang Jiang Hugang Jiang Hugang Jiang Xiaodong Zhi Xiaodong Zhi Xiaodong Zhi Chunling Wang Chunling Wang Chunling Wang Kai Liu Kai Liu Xinke Zhao Xinke Zhao Xinke Zhao Yingdong Li Yingdong Li Yingdong Li |
| author_facet | Qilin Chen Qilin Chen Qilin Chen Qilin Chen Chunzhen Ren Chunzhen Ren Chunzhen Ren Chang Shu Chang Shu Chang Shu Xue Yang Hugang Jiang Hugang Jiang Hugang Jiang Xiaodong Zhi Xiaodong Zhi Xiaodong Zhi Chunling Wang Chunling Wang Chunling Wang Kai Liu Kai Liu Xinke Zhao Xinke Zhao Xinke Zhao Yingdong Li Yingdong Li Yingdong Li |
| author_sort | Qilin Chen |
| collection | DOAJ |
| description | BackgroundHypertension is a major global public health challenge affecting over 1.3 billion people. Emerging evidence indicates that gut microbiota regulates blood pressure through metabolic and immune-inflammatory pathways. This provides novel insights into hypertension mechanisms and facilitates targeted interventions. However, research in this field faces three major challenges: (1) fragmented knowledge, (2) limited clinical translation, and (3) unclear developmental trajectories. Consequently, conventional reviews cannot adequately capture its dynamic evolution.ObjectiveUsing publications from the Web of Science Core Collection (2000–2025), we conducted a bibliometric analysis with CiteSpace and VOSviewer to map collaborative networks, analyze research hotspot evolution, identify emerging frontiers, and provide quantitative insights for field advancement.MethodsWe retrieved 2,827 qualified publications through Boolean logic search, then performed analyses including: annual publication trends, national/institutional/author collaboration networks, keyword co-occurrence and clustering, burst detection, and timeline/mountain range visualizations using CiteSpace and VOSviewer.ResultsPublication trends evolved through three phases: initial accumulation (annual output <50), accelerated growth, and stable maturation (250–450 annually). Driven by technology and clinical needs, China (918) and the US (676) led research, with networks involving Italy, Spain, etc. Academic institutions like the Univ. of Florida and Zhejiang Univ. were pivotal, and key teams (e.g., Yang Tao, Raizada Mohan K.) focused on mechanisms and translation. Research hotspots centered on “gut microbiota” and “blood pressure,” forming three modules: metabolic regulation, complication associations, and intervention strategies. Cluster analysis identified 10 groups—including short-chain fatty acids and TMAO—spanning basic to clinical research. Post-2017 foci like Akkermansia muciniphila, Mendelian randomization, and pulmonary hypertension signal a shift to precision mechanisms and personalized interventions.ConclusionThis study establishes a quantitative analytical framework for hypertension-gut microbiota research, revealing a collaborative landscape led by China and the United States with multidisciplinary integration. We identify metabolic reprogramming and microbiota-targeted interventions as core research priorities, providing theoretical foundations to address clinical translation barriers and advance precision medicine. Future research should strengthen cross-disciplinary collaboration, prioritize investigation of ethnicity-specific microbial signatures and microbiota-drug interactions, and accelerate clinical translation of targeted therapies. |
| format | Article |
| id | doaj-art-320e40e6304b4de395f683e8f9c36d72 |
| institution | Kabale University |
| issn | 1664-302X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-320e40e6304b4de395f683e8f9c36d722025-08-20T04:02:31ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2025-08-011610.3389/fmicb.2025.15432581543258Hypertension-gut microbiota research trends: a bibliometric and visualization analysis (2000–2025)Qilin Chen0Qilin Chen1Qilin Chen2Qilin Chen3Chunzhen Ren4Chunzhen Ren5Chunzhen Ren6Chang Shu7Chang Shu8Chang Shu9Xue Yang10Hugang Jiang11Hugang Jiang12Hugang Jiang13Xiaodong Zhi14Xiaodong Zhi15Xiaodong Zhi16Chunling Wang17Chunling Wang18Chunling Wang19Kai Liu20Kai Liu21Xinke Zhao22Xinke Zhao23Xinke Zhao24Yingdong Li25Yingdong Li26Yingdong Li27School of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, ChinaGansu Province Key Laboratory of Chinese Medicine for the Prevention and Treatment of Chronic Diseases, Lanzhou, ChinaDepartment of Traditional Chinese Medicine, KweiChow Moutai Hospital, Renhuai, ChinaKey Clinical Specialty of the National Health Commission of the People’s Republic of China, Key Specialized Cardiovascular Laboratory National Administration of Traditional Chinese Medicine, Lanzhou, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, ChinaGansu Province Key Laboratory of Chinese Medicine for the Prevention and Treatment of Chronic Diseases, Lanzhou, ChinaKey Clinical Specialty of the National Health Commission of the People’s Republic of China, Key Specialized Cardiovascular Laboratory National Administration of Traditional Chinese Medicine, Lanzhou, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, ChinaGansu Province Key Laboratory of Chinese Medicine for the Prevention and Treatment of Chronic Diseases, Lanzhou, ChinaKey Clinical Specialty of the National Health Commission of the People’s Republic of China, Key Specialized Cardiovascular Laboratory National Administration of Traditional Chinese Medicine, Lanzhou, ChinaDepartment of Traditional Chinese Medicine, KweiChow Moutai Hospital, Renhuai, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, ChinaGansu Province Key Laboratory of Chinese Medicine for the Prevention and Treatment of Chronic Diseases, Lanzhou, ChinaKey Clinical Specialty of the National Health Commission of the People’s Republic of China, Key Specialized Cardiovascular Laboratory National Administration of Traditional Chinese Medicine, Lanzhou, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, ChinaGansu Province Key Laboratory of Chinese Medicine for the Prevention and Treatment of Chronic Diseases, Lanzhou, ChinaKey Clinical Specialty of the National Health Commission of the People’s Republic of China, Key Specialized Cardiovascular Laboratory National Administration of Traditional Chinese Medicine, Lanzhou, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, ChinaGansu Province Key Laboratory of Chinese Medicine for the Prevention and Treatment of Chronic Diseases, Lanzhou, ChinaKey Clinical Specialty of the National Health Commission of the People’s Republic of China, Key Specialized Cardiovascular Laboratory National Administration of Traditional Chinese Medicine, Lanzhou, ChinaKey Clinical Specialty of the National Health Commission of the People’s Republic of China, Key Specialized Cardiovascular Laboratory National Administration of Traditional Chinese Medicine, Lanzhou, ChinaSchool of Clinical Medicine, Gansu Medical College, Pingliang, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, ChinaGansu Province Key Laboratory of Chinese Medicine for the Prevention and Treatment of Chronic Diseases, Lanzhou, ChinaKey Clinical Specialty of the National Health Commission of the People’s Republic of China, Key Specialized Cardiovascular Laboratory National Administration of Traditional Chinese Medicine, Lanzhou, ChinaSchool of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, ChinaGansu Province Key Laboratory of Chinese Medicine for the Prevention and Treatment of Chronic Diseases, Lanzhou, ChinaKey Clinical Specialty of the National Health Commission of the People’s Republic of China, Key Specialized Cardiovascular Laboratory National Administration of Traditional Chinese Medicine, Lanzhou, ChinaBackgroundHypertension is a major global public health challenge affecting over 1.3 billion people. Emerging evidence indicates that gut microbiota regulates blood pressure through metabolic and immune-inflammatory pathways. This provides novel insights into hypertension mechanisms and facilitates targeted interventions. However, research in this field faces three major challenges: (1) fragmented knowledge, (2) limited clinical translation, and (3) unclear developmental trajectories. Consequently, conventional reviews cannot adequately capture its dynamic evolution.ObjectiveUsing publications from the Web of Science Core Collection (2000–2025), we conducted a bibliometric analysis with CiteSpace and VOSviewer to map collaborative networks, analyze research hotspot evolution, identify emerging frontiers, and provide quantitative insights for field advancement.MethodsWe retrieved 2,827 qualified publications through Boolean logic search, then performed analyses including: annual publication trends, national/institutional/author collaboration networks, keyword co-occurrence and clustering, burst detection, and timeline/mountain range visualizations using CiteSpace and VOSviewer.ResultsPublication trends evolved through three phases: initial accumulation (annual output <50), accelerated growth, and stable maturation (250–450 annually). Driven by technology and clinical needs, China (918) and the US (676) led research, with networks involving Italy, Spain, etc. Academic institutions like the Univ. of Florida and Zhejiang Univ. were pivotal, and key teams (e.g., Yang Tao, Raizada Mohan K.) focused on mechanisms and translation. Research hotspots centered on “gut microbiota” and “blood pressure,” forming three modules: metabolic regulation, complication associations, and intervention strategies. Cluster analysis identified 10 groups—including short-chain fatty acids and TMAO—spanning basic to clinical research. Post-2017 foci like Akkermansia muciniphila, Mendelian randomization, and pulmonary hypertension signal a shift to precision mechanisms and personalized interventions.ConclusionThis study establishes a quantitative analytical framework for hypertension-gut microbiota research, revealing a collaborative landscape led by China and the United States with multidisciplinary integration. We identify metabolic reprogramming and microbiota-targeted interventions as core research priorities, providing theoretical foundations to address clinical translation barriers and advance precision medicine. Future research should strengthen cross-disciplinary collaboration, prioritize investigation of ethnicity-specific microbial signatures and microbiota-drug interactions, and accelerate clinical translation of targeted therapies.https://www.frontiersin.org/articles/10.3389/fmicb.2025.1543258/fullhypertensiongut microbiotabibliometric studyCiteSpaceVOSviewerresearch trends |
| spellingShingle | Qilin Chen Qilin Chen Qilin Chen Qilin Chen Chunzhen Ren Chunzhen Ren Chunzhen Ren Chang Shu Chang Shu Chang Shu Xue Yang Hugang Jiang Hugang Jiang Hugang Jiang Xiaodong Zhi Xiaodong Zhi Xiaodong Zhi Chunling Wang Chunling Wang Chunling Wang Kai Liu Kai Liu Xinke Zhao Xinke Zhao Xinke Zhao Yingdong Li Yingdong Li Yingdong Li Hypertension-gut microbiota research trends: a bibliometric and visualization analysis (2000–2025) Frontiers in Microbiology hypertension gut microbiota bibliometric study CiteSpace VOSviewer research trends |
| title | Hypertension-gut microbiota research trends: a bibliometric and visualization analysis (2000–2025) |
| title_full | Hypertension-gut microbiota research trends: a bibliometric and visualization analysis (2000–2025) |
| title_fullStr | Hypertension-gut microbiota research trends: a bibliometric and visualization analysis (2000–2025) |
| title_full_unstemmed | Hypertension-gut microbiota research trends: a bibliometric and visualization analysis (2000–2025) |
| title_short | Hypertension-gut microbiota research trends: a bibliometric and visualization analysis (2000–2025) |
| title_sort | hypertension gut microbiota research trends a bibliometric and visualization analysis 2000 2025 |
| topic | hypertension gut microbiota bibliometric study CiteSpace VOSviewer research trends |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2025.1543258/full |
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