Clinical applications of basophil activation test: a review
Basophils are one of the most important effector cells involved in IgE-mediated type I hypersensitivity and type 2 inflammation. Basophil activation test (BAT) simulates in vivo type I hyper-sensitivity. Flow cytometry is used in BAT to detect the expression level of specific surface markers on baso...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of New Medicine
2022-04-01
|
| Series: | Yixue xinzhi zazhi |
| Subjects: | |
| Online Access: | https://yxxz.whuznhmedj.com/storage/attach/2204/ladQFl8eQxzPWkiJiMWuUJ3dek7WcazMkEcMFbBv.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850105027469770752 |
|---|---|
| author | Ya-Dong GAO Jin-Jin ZHANG Guang-Hui LIU |
| author_facet | Ya-Dong GAO Jin-Jin ZHANG Guang-Hui LIU |
| author_sort | Ya-Dong GAO |
| collection | DOAJ |
| description | Basophils are one of the most important effector cells involved in IgE-mediated type I hypersensitivity and type 2 inflammation. Basophil activation test (BAT) simulates in vivo type I hyper-sensitivity. Flow cytometry is used in BAT to detect the expression level of specific surface markers on basophils after allergen stimulation, hence reflecting the degree of activation and status of basophils. As an allergen test in vitro, BAT shows good safety and high specificity. In clinical practice, it can be used for the auxiliary diagnosis of diseases such as food or drug allergy, airway allergic diseases, hymenoptera venom allergy and anaphylaxis. In addition, it can help to predict and monitor the efficacy of specific immunotherapy for different allergens. Allergen reagents, operational procedures and interpretation methods need to be further standardized to facilitate the popularization and application of BAT. |
| format | Article |
| id | doaj-art-3209d6a9290e4b5c98b1c377e4904e69 |
| institution | DOAJ |
| issn | 1004-5511 |
| language | zho |
| publishDate | 2022-04-01 |
| publisher | Editorial Office of New Medicine |
| record_format | Article |
| series | Yixue xinzhi zazhi |
| spelling | doaj-art-3209d6a9290e4b5c98b1c377e4904e692025-08-20T02:39:12ZzhoEditorial Office of New MedicineYixue xinzhi zazhi1004-55112022-04-0132214815510.12173/j.issn.1004-5511.202112114766315Clinical applications of basophil activation test: a reviewYa-Dong GAOJin-Jin ZHANGGuang-Hui LIUBasophils are one of the most important effector cells involved in IgE-mediated type I hypersensitivity and type 2 inflammation. Basophil activation test (BAT) simulates in vivo type I hyper-sensitivity. Flow cytometry is used in BAT to detect the expression level of specific surface markers on basophils after allergen stimulation, hence reflecting the degree of activation and status of basophils. As an allergen test in vitro, BAT shows good safety and high specificity. In clinical practice, it can be used for the auxiliary diagnosis of diseases such as food or drug allergy, airway allergic diseases, hymenoptera venom allergy and anaphylaxis. In addition, it can help to predict and monitor the efficacy of specific immunotherapy for different allergens. Allergen reagents, operational procedures and interpretation methods need to be further standardized to facilitate the popularization and application of BAT.https://yxxz.whuznhmedj.com/storage/attach/2204/ladQFl8eQxzPWkiJiMWuUJ3dek7WcazMkEcMFbBv.pdfbasophils basophil activation test flow cytometry allergen allergic disease |
| spellingShingle | Ya-Dong GAO Jin-Jin ZHANG Guang-Hui LIU Clinical applications of basophil activation test: a review Yixue xinzhi zazhi basophils basophil activation test flow cytometry allergen allergic disease |
| title | Clinical applications of basophil activation test: a review |
| title_full | Clinical applications of basophil activation test: a review |
| title_fullStr | Clinical applications of basophil activation test: a review |
| title_full_unstemmed | Clinical applications of basophil activation test: a review |
| title_short | Clinical applications of basophil activation test: a review |
| title_sort | clinical applications of basophil activation test a review |
| topic | basophils basophil activation test flow cytometry allergen allergic disease |
| url | https://yxxz.whuznhmedj.com/storage/attach/2204/ladQFl8eQxzPWkiJiMWuUJ3dek7WcazMkEcMFbBv.pdf |
| work_keys_str_mv | AT yadonggao clinicalapplicationsofbasophilactivationtestareview AT jinjinzhang clinicalapplicationsofbasophilactivationtestareview AT guanghuiliu clinicalapplicationsofbasophilactivationtestareview |