Role of neuromuscular ultrasound in the evaluation of amyotrophic lateral sclerosis
Abstract Background Amyotrophic lateral sclerosis (ALS) is the commonest presentation of adult motor neuron diseases. Diagnosis can be difficult due to the heterogenous clinical presentation of the disease. Most neuromuscular ultrasound studies focus on imaging the same structures belonging to one o...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2025-03-01
|
| Series: | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41983-025-00951-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850208371231162368 |
|---|---|
| author | Sherif Hassan Elwan Mohammed Saher Hashem Mona Mostafa Ghanem Sandra Mohammed Ahmed Hatem Samir Mohammed Basma Bahgat Elsayed |
| author_facet | Sherif Hassan Elwan Mohammed Saher Hashem Mona Mostafa Ghanem Sandra Mohammed Ahmed Hatem Samir Mohammed Basma Bahgat Elsayed |
| author_sort | Sherif Hassan Elwan |
| collection | DOAJ |
| description | Abstract Background Amyotrophic lateral sclerosis (ALS) is the commonest presentation of adult motor neuron diseases. Diagnosis can be difficult due to the heterogenous clinical presentation of the disease. Most neuromuscular ultrasound studies focus on imaging the same structures belonging to one or two segments of the neuroaxis. Facial nerve ultrasound has not been well investigated in ALS. This work aims at evaluating the role of neuromuscular ultrasound in diagnosing and monitoring ALS. Sixteen adult male patients diagnosed with clinically definite ALS, as well as twenty age and gender matched control subjects, were recruited. Each patient was given a score according to the ALS functional rating scale-revised edition. Electrophysiological studies and high-resolution ultrasound were performed on the Facial, Median, Ulnar, Tibial and Common peroneal nerves, as well as Masseter, Sternocleidomastoid, Biceps brachii/Brachialis complex, First Dorsal Interosseus, Vastus Intermedius/Rectus Femoris complex, and Tibialis anterior muscles. Results ALS patients demonstrated significantly decreased Facial nerve diameter, Tibial nerve cross sectional area, and thickness of Biceps/Brachialis complex, Tibialis anterior, First Dorsal Interosseus, and Vastus intermedius/Rectus femoris complex. Tibialis anterior thickness and Facial nerve diameter showed the highest sensitivity and specificity in monitoring clinical progression in ALS. Conclusion Neuromuscular ultrasound is a reliable objective tool in diagnosing and monitoring ALS. |
| format | Article |
| id | doaj-art-32034ccd62ac460eb81f5dec5ea95191 |
| institution | OA Journals |
| issn | 1687-8329 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Neurology, Psychiatry and Neurosurgery |
| spelling | doaj-art-32034ccd62ac460eb81f5dec5ea951912025-08-20T02:10:16ZengSpringerOpenThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery1687-83292025-03-016111910.1186/s41983-025-00951-yRole of neuromuscular ultrasound in the evaluation of amyotrophic lateral sclerosisSherif Hassan Elwan0Mohammed Saher Hashem1Mona Mostafa Ghanem2Sandra Mohammed Ahmed3Hatem Samir Mohammed4Basma Bahgat Elsayed5Department of Internal Medicine, National Research CenterDepartment of Neurology, New Giza UniversityDepartment of Internal Medicine, National Research CenterDepartment of Neurology, Faculty of Medicine, Cairo UniversityDepartment of Neurology, Faculty of Medicine, Cairo UniversityDepartment of Clinical Neurophysiology, Faculty of Medicine, Cairo UniversityAbstract Background Amyotrophic lateral sclerosis (ALS) is the commonest presentation of adult motor neuron diseases. Diagnosis can be difficult due to the heterogenous clinical presentation of the disease. Most neuromuscular ultrasound studies focus on imaging the same structures belonging to one or two segments of the neuroaxis. Facial nerve ultrasound has not been well investigated in ALS. This work aims at evaluating the role of neuromuscular ultrasound in diagnosing and monitoring ALS. Sixteen adult male patients diagnosed with clinically definite ALS, as well as twenty age and gender matched control subjects, were recruited. Each patient was given a score according to the ALS functional rating scale-revised edition. Electrophysiological studies and high-resolution ultrasound were performed on the Facial, Median, Ulnar, Tibial and Common peroneal nerves, as well as Masseter, Sternocleidomastoid, Biceps brachii/Brachialis complex, First Dorsal Interosseus, Vastus Intermedius/Rectus Femoris complex, and Tibialis anterior muscles. Results ALS patients demonstrated significantly decreased Facial nerve diameter, Tibial nerve cross sectional area, and thickness of Biceps/Brachialis complex, Tibialis anterior, First Dorsal Interosseus, and Vastus intermedius/Rectus femoris complex. Tibialis anterior thickness and Facial nerve diameter showed the highest sensitivity and specificity in monitoring clinical progression in ALS. Conclusion Neuromuscular ultrasound is a reliable objective tool in diagnosing and monitoring ALS.https://doi.org/10.1186/s41983-025-00951-yAmyotrophic lateral sclerosisNeuromuscular ultrasoundFasciculations |
| spellingShingle | Sherif Hassan Elwan Mohammed Saher Hashem Mona Mostafa Ghanem Sandra Mohammed Ahmed Hatem Samir Mohammed Basma Bahgat Elsayed Role of neuromuscular ultrasound in the evaluation of amyotrophic lateral sclerosis The Egyptian Journal of Neurology, Psychiatry and Neurosurgery Amyotrophic lateral sclerosis Neuromuscular ultrasound Fasciculations |
| title | Role of neuromuscular ultrasound in the evaluation of amyotrophic lateral sclerosis |
| title_full | Role of neuromuscular ultrasound in the evaluation of amyotrophic lateral sclerosis |
| title_fullStr | Role of neuromuscular ultrasound in the evaluation of amyotrophic lateral sclerosis |
| title_full_unstemmed | Role of neuromuscular ultrasound in the evaluation of amyotrophic lateral sclerosis |
| title_short | Role of neuromuscular ultrasound in the evaluation of amyotrophic lateral sclerosis |
| title_sort | role of neuromuscular ultrasound in the evaluation of amyotrophic lateral sclerosis |
| topic | Amyotrophic lateral sclerosis Neuromuscular ultrasound Fasciculations |
| url | https://doi.org/10.1186/s41983-025-00951-y |
| work_keys_str_mv | AT sherifhassanelwan roleofneuromuscularultrasoundintheevaluationofamyotrophiclateralsclerosis AT mohammedsaherhashem roleofneuromuscularultrasoundintheevaluationofamyotrophiclateralsclerosis AT monamostafaghanem roleofneuromuscularultrasoundintheevaluationofamyotrophiclateralsclerosis AT sandramohammedahmed roleofneuromuscularultrasoundintheevaluationofamyotrophiclateralsclerosis AT hatemsamirmohammed roleofneuromuscularultrasoundintheevaluationofamyotrophiclateralsclerosis AT basmabahgatelsayed roleofneuromuscularultrasoundintheevaluationofamyotrophiclateralsclerosis |