Pharmacological and physiological activation of TGR5 in the NTS lowers food intake by enhancing leptin-STAT3 signaling

Pharmacological and physiological activation of TGR5 in the NTS lowers food intake by enhancing leptin-STAT3 signaling

Abstract Feeding increases plasma bile acid levels while the nucleus of the solitary tract (NTS) and area postrema (AP) of the brain detect changes in hormones to regulate feeding. However, whether an increase in bile acids activates Takeda G protein-coupled receptor 5 (TGR5) in the NTS and/or AP to...

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Bibliographic Details
Main Authors: Kyla Bruce, Song-Yang Zhang, Ameth N. Garrido, Melissa T. Wang, Tomás P. Bachor, Pengcheng Wang, Allison W. Xu, Zeyu Yang, Tony K. T. Lam
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60331-1
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