Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment

Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment

Abstract Cisplatin-induced neurotoxicity is one of the limiting factors to its use especially in tumors that demand high drug dosage. One of the Cisplatin pathways is ferritinophagy which may end up in ferroptosis. So, we aimed to use iron chelator as a new strategy based on an anti-ferroptotic mech...

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Bibliographic Details
Main Authors: Hanan Seddiek, Mira Hanna, Amany Elsayed Mohamed Hamoud, Marawan Abd Elbaset, Ahmed M. A. Akabawy, Mohamed Zakaria Kotb, Mohamed Mansour Khalifa
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Cisplatin
Neurotoxicity
Deferiprone
Ferritinophagy
Ferroptosis
Online Access:https://doi.org/10.1038/s41598-025-87628-x
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