Regioselective Nucleophilic Aromatic Substitution: Theoretical and Experimental Insights into 4-Aminoquinazoline Synthesis as a Privileged Structure in Medicinal Chemistry

Regioselective Nucleophilic Aromatic Substitution: Theoretical and Experimental Insights into 4-Aminoquinazoline Synthesis as a Privileged Structure in Medicinal Chemistry

The 4-aminoquinazoline scaffold is a privileged structure in medicinal chemistry. Regioselective nucleophilic aromatic substitution (S<sub>N</sub>Ar) for replacing the chlorine atom at the 4-position of 2,4-dichloroquinazoline precursors is well documented in the scientific literature an...

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Bibliographic Details
Main Authors: Maria Letícia de Castro Barbosa, Pedro de Sena Murteira Pinheiro, Raissa Alves da Conceição, José Ricardo Pires, Lucas Silva Franco, Carlos Mauricio R. Sant’Anna, Eliezer J. Barreiro, Lídia Moreira Lima
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Molecules
Subjects:
aminoquinazoline
density functional calculations
NMR spectroscopy
nucleophilic substitution
regioselectivity
medicinal chemistry
Online Access:https://www.mdpi.com/1420-3049/29/24/6021
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