Protocol to investigate bivalent histone modification dynamics via chromatin immunoprecipitation followed by re-chromatin immunoprecipitation

Summary: Epigenetic modifications play key roles in regulating transcription by altering chromatin structure and accessibility in response to internal cues or external stimuli. Here, we present a protocol for assessing bivalent histone modification changes through chromatin immunoprecipitation (ChIP...

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Main Authors: Zhengyao Shao, Hong Qiao
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:STAR Protocols
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166725002102
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author Zhengyao Shao
Hong Qiao
author_facet Zhengyao Shao
Hong Qiao
author_sort Zhengyao Shao
collection DOAJ
description Summary: Epigenetic modifications play key roles in regulating transcription by altering chromatin structure and accessibility in response to internal cues or external stimuli. Here, we present a protocol for assessing bivalent histone modification changes through chromatin immunoprecipitation (ChIP)-reChIP assay in response to warm ambient temperature in Arabidopsis. We describe steps to perform transient warm ambient temperature treatment on Arabidopsis seedlings. We then detailed procedures for ChIP-reChIP, which can be applied to investigate various DNA-protein interaction dynamics in different experimental contexts.For complete details on the use and execution of this protocol, please refer to Shao et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.
format Article
id doaj-art-31f975f2dd2c4c97bd92fd53ab973a14
institution DOAJ
issn 2666-1667
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publishDate 2025-06-01
publisher Elsevier
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series STAR Protocols
spelling doaj-art-31f975f2dd2c4c97bd92fd53ab973a142025-08-20T03:11:06ZengElsevierSTAR Protocols2666-16672025-06-016210380410.1016/j.xpro.2025.103804Protocol to investigate bivalent histone modification dynamics via chromatin immunoprecipitation followed by re-chromatin immunoprecipitationZhengyao Shao0Hong Qiao1Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA; Corresponding authorInstitute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, USA; Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX 78712, USA; Corresponding authorSummary: Epigenetic modifications play key roles in regulating transcription by altering chromatin structure and accessibility in response to internal cues or external stimuli. Here, we present a protocol for assessing bivalent histone modification changes through chromatin immunoprecipitation (ChIP)-reChIP assay in response to warm ambient temperature in Arabidopsis. We describe steps to perform transient warm ambient temperature treatment on Arabidopsis seedlings. We then detailed procedures for ChIP-reChIP, which can be applied to investigate various DNA-protein interaction dynamics in different experimental contexts.For complete details on the use and execution of this protocol, please refer to Shao et al.1 : Publisher’s note: Undertaking any experimental protocol requires adherence to local institutional guidelines for laboratory safety and ethics.http://www.sciencedirect.com/science/article/pii/S2666166725002102Plant sciencesMolecular BiologyChromatin immunoprecipitationChIP
spellingShingle Zhengyao Shao
Hong Qiao
Protocol to investigate bivalent histone modification dynamics via chromatin immunoprecipitation followed by re-chromatin immunoprecipitation
STAR Protocols
Plant sciences
Molecular Biology
Chromatin immunoprecipitation
ChIP
title Protocol to investigate bivalent histone modification dynamics via chromatin immunoprecipitation followed by re-chromatin immunoprecipitation
title_full Protocol to investigate bivalent histone modification dynamics via chromatin immunoprecipitation followed by re-chromatin immunoprecipitation
title_fullStr Protocol to investigate bivalent histone modification dynamics via chromatin immunoprecipitation followed by re-chromatin immunoprecipitation
title_full_unstemmed Protocol to investigate bivalent histone modification dynamics via chromatin immunoprecipitation followed by re-chromatin immunoprecipitation
title_short Protocol to investigate bivalent histone modification dynamics via chromatin immunoprecipitation followed by re-chromatin immunoprecipitation
title_sort protocol to investigate bivalent histone modification dynamics via chromatin immunoprecipitation followed by re chromatin immunoprecipitation
topic Plant sciences
Molecular Biology
Chromatin immunoprecipitation
ChIP
url http://www.sciencedirect.com/science/article/pii/S2666166725002102
work_keys_str_mv AT zhengyaoshao protocoltoinvestigatebivalenthistonemodificationdynamicsviachromatinimmunoprecipitationfollowedbyrechromatinimmunoprecipitation
AT hongqiao protocoltoinvestigatebivalenthistonemodificationdynamicsviachromatinimmunoprecipitationfollowedbyrechromatinimmunoprecipitation