The biology of exosomes and exosomal non-coding RNAs in cardiovascular diseases
Cardiovascular diseases (CVDs) remain the leading cause of death worldwide, both in developed and developing countries. Despite the implementation of various measures in clinical practice that have shown certain curative effects, poor prognosis and irreversible pathological cardiac remodeling contin...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1529375/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849325168606838784 |
|---|---|
| author | Lu Gan Xiaofei Guo Shichao Dong Chuan Sun |
| author_facet | Lu Gan Xiaofei Guo Shichao Dong Chuan Sun |
| author_sort | Lu Gan |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) remain the leading cause of death worldwide, both in developed and developing countries. Despite the implementation of various measures in clinical practice that have shown certain curative effects, poor prognosis and irreversible pathological cardiac remodeling continue to limit the therapeutic effect of CVDs. There are still many new mechanisms worth exploring for the regulation of CVDs. Previous studies have highlighted the potential applicability of exosomes in CVDs, and significant research has been conducted in this area. In this review, we summarize the physiological mechanisms of exosomes and the basic research achievements in regulating CVDs via exosomal non-coding RNAs. We also discuss the limitations and prospects of exosome application in CVD treatment. |
| format | Article |
| id | doaj-art-31f925702bfb4dafa0cb3d4018a52259 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-31f925702bfb4dafa0cb3d4018a522592025-08-20T03:48:28ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-05-011610.3389/fphar.2025.15293751529375The biology of exosomes and exosomal non-coding RNAs in cardiovascular diseasesLu Gan0Xiaofei Guo1Shichao Dong2Chuan Sun3Department of Pharmacy, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaDepartment of Pharmacy, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, ChinaDepartment of Pharmacy, The Second Hospital of Tianjin Medical University, Tianjin, ChinaDepartment of Pharmacy, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu, ChinaCardiovascular diseases (CVDs) remain the leading cause of death worldwide, both in developed and developing countries. Despite the implementation of various measures in clinical practice that have shown certain curative effects, poor prognosis and irreversible pathological cardiac remodeling continue to limit the therapeutic effect of CVDs. There are still many new mechanisms worth exploring for the regulation of CVDs. Previous studies have highlighted the potential applicability of exosomes in CVDs, and significant research has been conducted in this area. In this review, we summarize the physiological mechanisms of exosomes and the basic research achievements in regulating CVDs via exosomal non-coding RNAs. We also discuss the limitations and prospects of exosome application in CVD treatment.https://www.frontiersin.org/articles/10.3389/fphar.2025.1529375/fullexosomesnon-coding RNAscardiovascular diseasesbiomarkerintercellular delivery systems |
| spellingShingle | Lu Gan Xiaofei Guo Shichao Dong Chuan Sun The biology of exosomes and exosomal non-coding RNAs in cardiovascular diseases Frontiers in Pharmacology exosomes non-coding RNAs cardiovascular diseases biomarker intercellular delivery systems |
| title | The biology of exosomes and exosomal non-coding RNAs in cardiovascular diseases |
| title_full | The biology of exosomes and exosomal non-coding RNAs in cardiovascular diseases |
| title_fullStr | The biology of exosomes and exosomal non-coding RNAs in cardiovascular diseases |
| title_full_unstemmed | The biology of exosomes and exosomal non-coding RNAs in cardiovascular diseases |
| title_short | The biology of exosomes and exosomal non-coding RNAs in cardiovascular diseases |
| title_sort | biology of exosomes and exosomal non coding rnas in cardiovascular diseases |
| topic | exosomes non-coding RNAs cardiovascular diseases biomarker intercellular delivery systems |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1529375/full |
| work_keys_str_mv | AT lugan thebiologyofexosomesandexosomalnoncodingrnasincardiovasculardiseases AT xiaofeiguo thebiologyofexosomesandexosomalnoncodingrnasincardiovasculardiseases AT shichaodong thebiologyofexosomesandexosomalnoncodingrnasincardiovasculardiseases AT chuansun thebiologyofexosomesandexosomalnoncodingrnasincardiovasculardiseases AT lugan biologyofexosomesandexosomalnoncodingrnasincardiovasculardiseases AT xiaofeiguo biologyofexosomesandexosomalnoncodingrnasincardiovasculardiseases AT shichaodong biologyofexosomesandexosomalnoncodingrnasincardiovasculardiseases AT chuansun biologyofexosomesandexosomalnoncodingrnasincardiovasculardiseases |