Chronic Mild Prenatal Stress Exacerbates the Allergen-Induced Airway Inflammation in Rats
The effects of chronic mild prenatal stress on leukocyte infiltration into the airways was investigated in rat offspring. The chronic prenatal stress consisted of transitory and variable changes in the rat's living conditions. Offspring at adult age were actively sensitized (day 0) and intratra...
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| Format: | Article |
| Language: | English |
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Wiley
1999-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/09629359990621 |
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| author | Paulo J. Nogueira Heloisa H. A. Ferreira Edson Antunes Nancy A. Teixeira |
| author_facet | Paulo J. Nogueira Heloisa H. A. Ferreira Edson Antunes Nancy A. Teixeira |
| author_sort | Paulo J. Nogueira |
| collection | DOAJ |
| description | The effects of chronic mild prenatal stress on leukocyte infiltration into the airways was investigated in rat offspring. The chronic prenatal stress consisted of transitory and variable changes in the rat's living conditions. Offspring at adult age were actively sensitized (day 0) and intratracheally challenged (day 14) with ovalbumin. Bronchoalveolar lavage was performed in the offspring at 48 h after intratracheal challenge with ovalbumin. A significant increase in total leukocyte infiltration was observed in the nonstressed offspring group and this was associated with a marked recruitment of eosinophils without a significant effect on the influx of neutrophils and mononuclear cells. In the prenatal stressed offspring, the counts of both total leukocyte and eosinophils, as well as mononuclear cells, was increased by 50% compared to the non-stressed offspring. We provide here the first experimental evidence that chronic mild unpredictable prenatal stress produces a marked increase in the allergen-induced airway inflammation in the rat offspring. |
| format | Article |
| id | doaj-art-31f7bd472a7148b9bfb3cf231521da61 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-31f7bd472a7148b9bfb3cf231521da612025-08-20T03:55:03ZengWileyMediators of Inflammation0962-93511466-18611999-01-018211912210.1080/09629359990621Chronic Mild Prenatal Stress Exacerbates the Allergen-Induced Airway Inflammation in RatsPaulo J. Nogueira0Heloisa H. A. Ferreira1Edson Antunes2Nancy A. Teixeira3Departamento de Farmacologia, Instituto de Biociências, Universidade Estadual Paulista, Botucatu, SP, BrazilUniversidade São Francisco, Bragança Paulista, SP, BrazilDepartamento de Farmacologia, Faculdade de Ciências Médicas, UNICAMP, P.O. Boc 6111, Campinas, (SP) 13081–970, BrazilDepartamento de Farmacologia, Faculdade de Ciências Médicas, UNICAMP, P.O. Boc 6111, Campinas, (SP) 13081–970, BrazilThe effects of chronic mild prenatal stress on leukocyte infiltration into the airways was investigated in rat offspring. The chronic prenatal stress consisted of transitory and variable changes in the rat's living conditions. Offspring at adult age were actively sensitized (day 0) and intratracheally challenged (day 14) with ovalbumin. Bronchoalveolar lavage was performed in the offspring at 48 h after intratracheal challenge with ovalbumin. A significant increase in total leukocyte infiltration was observed in the nonstressed offspring group and this was associated with a marked recruitment of eosinophils without a significant effect on the influx of neutrophils and mononuclear cells. In the prenatal stressed offspring, the counts of both total leukocyte and eosinophils, as well as mononuclear cells, was increased by 50% compared to the non-stressed offspring. We provide here the first experimental evidence that chronic mild unpredictable prenatal stress produces a marked increase in the allergen-induced airway inflammation in the rat offspring.http://dx.doi.org/10.1080/09629359990621Prenatal stress; Eosinophils; Asthma; Development; Lungs. |
| spellingShingle | Paulo J. Nogueira Heloisa H. A. Ferreira Edson Antunes Nancy A. Teixeira Chronic Mild Prenatal Stress Exacerbates the Allergen-Induced Airway Inflammation in Rats Mediators of Inflammation Prenatal stress; Eosinophils; Asthma; Development; Lungs. |
| title | Chronic Mild Prenatal Stress Exacerbates the Allergen-Induced Airway Inflammation in Rats |
| title_full | Chronic Mild Prenatal Stress Exacerbates the Allergen-Induced Airway Inflammation in Rats |
| title_fullStr | Chronic Mild Prenatal Stress Exacerbates the Allergen-Induced Airway Inflammation in Rats |
| title_full_unstemmed | Chronic Mild Prenatal Stress Exacerbates the Allergen-Induced Airway Inflammation in Rats |
| title_short | Chronic Mild Prenatal Stress Exacerbates the Allergen-Induced Airway Inflammation in Rats |
| title_sort | chronic mild prenatal stress exacerbates the allergen induced airway inflammation in rats |
| topic | Prenatal stress; Eosinophils; Asthma; Development; Lungs. |
| url | http://dx.doi.org/10.1080/09629359990621 |
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