Enhancing the antioxidant capacity of Fe single-atom nanozymes through local coordination manipulation for psoriasis treatment
Psoriasis is a chronic skin condition with significant unmet medical needs, characterized by high levels of reactive oxygen species (ROS) and accompanying oxidative stress. In this study, we developed a novel single-atom iron nanozyme (Fe-N3), designed to mimic natural antioxidant enzymes, for the e...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425003904 |
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| author | Hongjin Xue Yunqian Li Xinyu Ma Qi Zhang Junkai Zhu Xiaoli Ni Jianfeng Qiu Zhengjun Li Zhen Mu |
| author_facet | Hongjin Xue Yunqian Li Xinyu Ma Qi Zhang Junkai Zhu Xiaoli Ni Jianfeng Qiu Zhengjun Li Zhen Mu |
| author_sort | Hongjin Xue |
| collection | DOAJ |
| description | Psoriasis is a chronic skin condition with significant unmet medical needs, characterized by high levels of reactive oxygen species (ROS) and accompanying oxidative stress. In this study, we developed a novel single-atom iron nanozyme (Fe-N3), designed to mimic natural antioxidant enzymes, for the effective treatment of psoriasis. By optimizing the local coordination environment of Fe atoms, Fe-N3 demonstrated superior superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APx), and glutathione peroxidase (GPx)-like activities compared to Fe-N4. These properties enable efficient ROS scavenging and oxidative stress alleviation. Theoretical analyses revealed that Fe-N3 possesses lower energy barriers for ROS decomposition, explaining its superior catalytic performance. Furthermore, in vitro and in vivo experiments have demonstrated that Fe-N3 nanozyme exhibited remarkable therapeutic effects with extremely low cytotoxicity, effectively inhibiting pathological epidermal proliferation, downregulating key inflammatory factors, and reducing the expression levels of psoriasis-associated pathway proteins. This work highlights the promise of single-atom nanozymes in the curing of inflammatory skin diseases, advancing the transformative role of nanotechnology in biomedicine. |
| format | Article |
| id | doaj-art-31f71210250c4cb38dcbfb6cc2a627f2 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-31f71210250c4cb38dcbfb6cc2a627f22025-08-20T03:52:37ZengElsevierMaterials Today Bio2590-00642025-06-013210183010.1016/j.mtbio.2025.101830Enhancing the antioxidant capacity of Fe single-atom nanozymes through local coordination manipulation for psoriasis treatmentHongjin Xue0Yunqian Li1Xinyu Ma2Qi Zhang3Junkai Zhu4Xiaoli Ni5Jianfeng Qiu6Zhengjun Li7Zhen Mu8Medical Engineering and Technology Research Center, School of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, ChinaDepartment of Dermatology, Laboratory of Basic Medical Science, Qilu Hospital Shandong University, Jinan, 250000, China; Laboratory of Basic Medical Science, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, ChinaMedical Engineering and Technology Research Center, School of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, ChinaMedical Engineering and Technology Research Center, School of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, ChinaTaian 88 Hospital RongTong Medical Healthcare Group Co.Ltd, Tai'an, 271000, ChinaDepartment of Dermatology, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, 271000, ChinaMedical Engineering and Technology Research Center, School of Radiology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, ChinaDepartment of Dermatology, Laboratory of Basic Medical Science, Qilu Hospital Shandong University, Jinan, 250000, China; Corresponding author.Department of Dermatology, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, 271000, China; Corresponding author.Psoriasis is a chronic skin condition with significant unmet medical needs, characterized by high levels of reactive oxygen species (ROS) and accompanying oxidative stress. In this study, we developed a novel single-atom iron nanozyme (Fe-N3), designed to mimic natural antioxidant enzymes, for the effective treatment of psoriasis. By optimizing the local coordination environment of Fe atoms, Fe-N3 demonstrated superior superoxide dismutase (SOD), catalase (CAT), ascorbate peroxidase (APx), and glutathione peroxidase (GPx)-like activities compared to Fe-N4. These properties enable efficient ROS scavenging and oxidative stress alleviation. Theoretical analyses revealed that Fe-N3 possesses lower energy barriers for ROS decomposition, explaining its superior catalytic performance. Furthermore, in vitro and in vivo experiments have demonstrated that Fe-N3 nanozyme exhibited remarkable therapeutic effects with extremely low cytotoxicity, effectively inhibiting pathological epidermal proliferation, downregulating key inflammatory factors, and reducing the expression levels of psoriasis-associated pathway proteins. This work highlights the promise of single-atom nanozymes in the curing of inflammatory skin diseases, advancing the transformative role of nanotechnology in biomedicine.http://www.sciencedirect.com/science/article/pii/S2590006425003904PsoriasisSingle-atom nanozymesReactive oxygen speciesIron catalystsEnzyme mimetics |
| spellingShingle | Hongjin Xue Yunqian Li Xinyu Ma Qi Zhang Junkai Zhu Xiaoli Ni Jianfeng Qiu Zhengjun Li Zhen Mu Enhancing the antioxidant capacity of Fe single-atom nanozymes through local coordination manipulation for psoriasis treatment Materials Today Bio Psoriasis Single-atom nanozymes Reactive oxygen species Iron catalysts Enzyme mimetics |
| title | Enhancing the antioxidant capacity of Fe single-atom nanozymes through local coordination manipulation for psoriasis treatment |
| title_full | Enhancing the antioxidant capacity of Fe single-atom nanozymes through local coordination manipulation for psoriasis treatment |
| title_fullStr | Enhancing the antioxidant capacity of Fe single-atom nanozymes through local coordination manipulation for psoriasis treatment |
| title_full_unstemmed | Enhancing the antioxidant capacity of Fe single-atom nanozymes through local coordination manipulation for psoriasis treatment |
| title_short | Enhancing the antioxidant capacity of Fe single-atom nanozymes through local coordination manipulation for psoriasis treatment |
| title_sort | enhancing the antioxidant capacity of fe single atom nanozymes through local coordination manipulation for psoriasis treatment |
| topic | Psoriasis Single-atom nanozymes Reactive oxygen species Iron catalysts Enzyme mimetics |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425003904 |
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