Exhaled volatile organic compounds in the detection of colorectal cancer
There is an apparent need for novel non-invasive colorectal cancer (CRC) screening tests that are more acceptable to patients and can reliably detect CRC or reduce the number of unnecessary colonoscopies performed in cancer-free patients. An emerging number of studies demonstrate the potential value...
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| Format: | Article |
| Language: | English |
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IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund
2024-05-01
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| Series: | EXCLI Journal : Experimental and Clinical Sciences |
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| Online Access: | https://www.excli.de/excli/article/view/7042 |
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| author | Daniah Alsaadi Nicolle Clements Natiya Gabuniya Nader Francis Manish Chand |
| author_facet | Daniah Alsaadi Nicolle Clements Natiya Gabuniya Nader Francis Manish Chand |
| author_sort | Daniah Alsaadi |
| collection | DOAJ |
| description | There is an apparent need for novel non-invasive colorectal cancer (CRC) screening tests that are more acceptable to patients and can reliably detect CRC or reduce the number of unnecessary colonoscopies performed in cancer-free patients. An emerging number of studies demonstrate the potential value of exhaled volatile organic compounds (VOCs) as a diagnostic and triaging test for CRC. A systematic appraisal and meta-analysis of the published evidence was done to determine whether exhaled VOCs can be used in the detection and screening of CRC. Nine electronic databases were searched from inception of the databases until August 2020. Quantitative and descriptive data of CRC patients and healthy control (HC) participants who underwent VOCs breath analysis was extracted. In addition, where possible, sampling methods, analytical platforms, processors, and specific breath biomarkers found in each study were recorded. Fourteen articles were included in the systematic review with 491 colorectal patients and 754 HC participants (n=1245). Sub-group meta-analysis was conducted on nine of those articles and the pooled sensitivity was estimated to be 0.89 (95 % CI = 0.80-0.99) whereas specificity was 0.83 (95 % CI = 0.74-0.92). Heterogeneity of pooled sensitivity and specificity was estimated as I2=11.11 %. Although this study was limited by small sample size and different analytical platforms, the proposed future framework resolves such limitations and standardizes future research. It is reasonable to deduce that VOCs breath analysis is certainly a field of research that can progress to replace traditional methods within the framework of CRC screening and diagnosis. |
| format | Article |
| id | doaj-art-31eb5778748a40f8b9c2f451e6a963d3 |
| institution | OA Journals |
| issn | 1611-2156 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund |
| record_format | Article |
| series | EXCLI Journal : Experimental and Clinical Sciences |
| spelling | doaj-art-31eb5778748a40f8b9c2f451e6a963d32025-08-20T02:10:32ZengIfADo - Leibniz Research Centre for Working Environment and Human Factors, DortmundEXCLI Journal : Experimental and Clinical Sciences1611-21562024-05-012379581010.17179/excli2024-70426481Exhaled volatile organic compounds in the detection of colorectal cancerDaniah Alsaadi0https://orcid.org/0000-0003-3497-1828Nicolle Clements1https://orcid.org/0009-0006-5464-8541Natiya Gabuniya2https://orcid.org/0009-0005-1716-7055Nader Francis3https://orcid.org/0000-0001-8498-9175Manish Chand4https://orcid.org/0000-0001-9086-8724The Division of Surgery and Interventional Science, University College London, London, United Kingdom. E-mail: daniah.alsaadi@outlook.comClinical Research Facility Galway, Galway University Hospital, National University of Ireland, Galway, Republic of IrelandThe Division of Surgery and Interventional Science, University College London, London, United Kingdom; Plastic and Reconstructive Surgery Department, Guy's and St Thomas' Hospital, London, United KingdomThe Division of Surgery and Interventional Science, University College London, London, United Kingdom; Department of General Surgery, Yeovil District Hospital NHS Foundation Trust, Yeovil, United KingdomThe Division of Surgery and Interventional Science, University College London, London, United KingdomThere is an apparent need for novel non-invasive colorectal cancer (CRC) screening tests that are more acceptable to patients and can reliably detect CRC or reduce the number of unnecessary colonoscopies performed in cancer-free patients. An emerging number of studies demonstrate the potential value of exhaled volatile organic compounds (VOCs) as a diagnostic and triaging test for CRC. A systematic appraisal and meta-analysis of the published evidence was done to determine whether exhaled VOCs can be used in the detection and screening of CRC. Nine electronic databases were searched from inception of the databases until August 2020. Quantitative and descriptive data of CRC patients and healthy control (HC) participants who underwent VOCs breath analysis was extracted. In addition, where possible, sampling methods, analytical platforms, processors, and specific breath biomarkers found in each study were recorded. Fourteen articles were included in the systematic review with 491 colorectal patients and 754 HC participants (n=1245). Sub-group meta-analysis was conducted on nine of those articles and the pooled sensitivity was estimated to be 0.89 (95 % CI = 0.80-0.99) whereas specificity was 0.83 (95 % CI = 0.74-0.92). Heterogeneity of pooled sensitivity and specificity was estimated as I2=11.11 %. Although this study was limited by small sample size and different analytical platforms, the proposed future framework resolves such limitations and standardizes future research. It is reasonable to deduce that VOCs breath analysis is certainly a field of research that can progress to replace traditional methods within the framework of CRC screening and diagnosis.https://www.excli.de/excli/article/view/7042colorectal cancervolatile organic compoundsexhaledbreath analysis |
| spellingShingle | Daniah Alsaadi Nicolle Clements Natiya Gabuniya Nader Francis Manish Chand Exhaled volatile organic compounds in the detection of colorectal cancer EXCLI Journal : Experimental and Clinical Sciences colorectal cancer volatile organic compounds exhaled breath analysis |
| title | Exhaled volatile organic compounds in the detection of colorectal cancer |
| title_full | Exhaled volatile organic compounds in the detection of colorectal cancer |
| title_fullStr | Exhaled volatile organic compounds in the detection of colorectal cancer |
| title_full_unstemmed | Exhaled volatile organic compounds in the detection of colorectal cancer |
| title_short | Exhaled volatile organic compounds in the detection of colorectal cancer |
| title_sort | exhaled volatile organic compounds in the detection of colorectal cancer |
| topic | colorectal cancer volatile organic compounds exhaled breath analysis |
| url | https://www.excli.de/excli/article/view/7042 |
| work_keys_str_mv | AT daniahalsaadi exhaledvolatileorganiccompoundsinthedetectionofcolorectalcancer AT nicolleclements exhaledvolatileorganiccompoundsinthedetectionofcolorectalcancer AT natiyagabuniya exhaledvolatileorganiccompoundsinthedetectionofcolorectalcancer AT naderfrancis exhaledvolatileorganiccompoundsinthedetectionofcolorectalcancer AT manishchand exhaledvolatileorganiccompoundsinthedetectionofcolorectalcancer |