Loss of UBE3A impacts both neuronal and non-neuronal cells in human cerebral organoids

Loss of UBE3A impacts both neuronal and non-neuronal cells in human cerebral organoids

Abstract Angelman syndrome is a neurodevelopmental disorder caused by (epi)genetic lesions of maternal UBE3A. Research has focused largely on the role of UBE3A in neurons due to its imprinting in that cell type. Yet, evidence suggests there may be broader neurodevelopmental impacts of UBE3A dysregul...

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Bibliographic Details
Main Authors: R. Chris Estridge, Z. Begum Yagci, Dilara Sen, Tyler J. Johnson, Gautami R. Kelkar, Travis S. Ptacek, Jeremy M. Simon, Albert J. Keung
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08262-x
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