Renalase inhibition defends against acute and chronic β cell stress by regulating cell metabolism

Renalase inhibition defends against acute and chronic β cell stress by regulating cell metabolism

Objective: Renalase (Rnls) is annotated as an oxidase enzyme. It has been implicated in Type 1 diabetes (T1D) risk via genome-wide association studies (GWAS). We previously discovered through CRISPR screening and validation experiments that Rnls inhibition prevents or delays T1D in multiple mouse mo...

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Main Authors: Tara L. MacDonald, Birgitta Ryback, Jéssica Aparecida da Silva Pereira, Siying Wei, Bryhan Mendez, Erica P. Cai, Yuki Ishikawa, Meagan Arbeau, Gordon Weir, Susan Bonner-Weir, Stephan Kissler, Peng Yi
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Molecular Metabolism
Subjects:
Diabetes
Cellular stress
Glucose metabolism
Pancreatic beta cells
Pancreatic islets
Animal phenotyping and physiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825000225
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