Impact of Sucrose Consumption on the Metabolic, Immune, and Redox Profile of Mice with Gestational Diabetes Mellitus
Carbohydrate consumption during pregnancy represents an important source of energy; its consumption, however, can cause gestational diabetes mellitus (GDM), body weight gain, inflammation, increased glucose transport to the fetus, adiposity, and a risk of macrosomia. The objective was to research th...
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2025-06-01
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| author | Cristian Ángel Rosales-Gómez Beatriz Elina Martínez-Carrillo Ana Laura Guadarrama-López Aldo Arturo Reséndiz-Albor Ivonne Maciel Arciniega-Martínez Efrén Aguilar-Rodríguez |
| author_facet | Cristian Ángel Rosales-Gómez Beatriz Elina Martínez-Carrillo Ana Laura Guadarrama-López Aldo Arturo Reséndiz-Albor Ivonne Maciel Arciniega-Martínez Efrén Aguilar-Rodríguez |
| author_sort | Cristian Ángel Rosales-Gómez |
| collection | DOAJ |
| description | Carbohydrate consumption during pregnancy represents an important source of energy; its consumption, however, can cause gestational diabetes mellitus (GDM), body weight gain, inflammation, increased glucose transport to the fetus, adiposity, and a risk of macrosomia. The objective was to research the impact of sucrose consumption during pregnancy on the metabolic, immune, and redox profile in female mice with GDM. A total of 24 female CD1 mice were used, divided into two groups: Control and GDM. Each group was subdivided into two subgroups: (a) Without sucrose and (b) With sucrose. The females were mated, and, once pregnancy was confirmed, GDM was induced by administering 230 mg/kg of streptozotocin subcutaneously. GDM was confirmed by glucose ≥ 200 mg/dL and the presence of polyphagia, polydipsia, and change in body weight. Metabolic, immune, and redox profile parameters were determined. Sucrose consumption groups increase HOMA-IR and the secretion of insulin, adiponectin, and leptin; it also increased the secretion of proinflammatory cytokines and the production of IgA and IgG antibodies, decreased the activity of the Glutathione Reductase enzyme, and increased the production of TBARS and AGE. High sucrose consumption increases the inflammatory response mediated mainly by CD8<sup>+</sup> lymphocytes and the production of proinflammatory cytokines; it can trigger a compensatory humoral response and alter redox mechanisms, causing a state of Oxidant Stress. |
| format | Article |
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| institution | DOAJ |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Life |
| spelling | doaj-art-31dc9de5be9345a69cb449e500577e102025-08-20T03:07:55ZengMDPI AGLife2075-17292025-06-0115798910.3390/life15070989Impact of Sucrose Consumption on the Metabolic, Immune, and Redox Profile of Mice with Gestational Diabetes MellitusCristian Ángel Rosales-Gómez0Beatriz Elina Martínez-Carrillo1Ana Laura Guadarrama-López2Aldo Arturo Reséndiz-Albor3Ivonne Maciel Arciniega-Martínez4Efrén Aguilar-Rodríguez5Laboratorio de Investigación en Nutrición, Facultad de Medicina, Universidad Autónoma del Estado de México, Paseo Tollocan Esquina Jesús Carranza s/n, Colonia Moderna de la Cruz, Toluca C.P. 50180, MexicoLaboratorio de Investigación en Nutrición, Facultad de Medicina, Universidad Autónoma del Estado de México, Paseo Tollocan Esquina Jesús Carranza s/n, Colonia Moderna de la Cruz, Toluca C.P. 50180, MexicoClínica Multidisciplinaria de Salud, Universidad Autónoma del Estado de México, Jesús Carranza Esquina Venustiano Carranza No.205, Colonia Universidad, Toluca C.P. 50130, MexicoLaboratorio de Inmunología de Mucosas, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Colonia Casco de Santo Tomás, Alcaldía Miguel Hidalgo, Ciudad de México C.P. 11340, MexicoLaboratorio de Inmunonutrición, Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón s/n, Colonia Casco de Santo Tomás, Alcaldía Miguel Hidalgo, Ciudad de México C.P. 11340, MexicoLaboratorio de Investigación en Nutrición, Facultad de Medicina, Universidad Autónoma del Estado de México, Paseo Tollocan Esquina Jesús Carranza s/n, Colonia Moderna de la Cruz, Toluca C.P. 50180, MexicoCarbohydrate consumption during pregnancy represents an important source of energy; its consumption, however, can cause gestational diabetes mellitus (GDM), body weight gain, inflammation, increased glucose transport to the fetus, adiposity, and a risk of macrosomia. The objective was to research the impact of sucrose consumption during pregnancy on the metabolic, immune, and redox profile in female mice with GDM. A total of 24 female CD1 mice were used, divided into two groups: Control and GDM. Each group was subdivided into two subgroups: (a) Without sucrose and (b) With sucrose. The females were mated, and, once pregnancy was confirmed, GDM was induced by administering 230 mg/kg of streptozotocin subcutaneously. GDM was confirmed by glucose ≥ 200 mg/dL and the presence of polyphagia, polydipsia, and change in body weight. Metabolic, immune, and redox profile parameters were determined. Sucrose consumption groups increase HOMA-IR and the secretion of insulin, adiponectin, and leptin; it also increased the secretion of proinflammatory cytokines and the production of IgA and IgG antibodies, decreased the activity of the Glutathione Reductase enzyme, and increased the production of TBARS and AGE. High sucrose consumption increases the inflammatory response mediated mainly by CD8<sup>+</sup> lymphocytes and the production of proinflammatory cytokines; it can trigger a compensatory humoral response and alter redox mechanisms, causing a state of Oxidant Stress.https://www.mdpi.com/2075-1729/15/7/989gestational diabetes mellitussucroseimmune responseredox mechanisms |
| spellingShingle | Cristian Ángel Rosales-Gómez Beatriz Elina Martínez-Carrillo Ana Laura Guadarrama-López Aldo Arturo Reséndiz-Albor Ivonne Maciel Arciniega-Martínez Efrén Aguilar-Rodríguez Impact of Sucrose Consumption on the Metabolic, Immune, and Redox Profile of Mice with Gestational Diabetes Mellitus Life gestational diabetes mellitus sucrose immune response redox mechanisms |
| title | Impact of Sucrose Consumption on the Metabolic, Immune, and Redox Profile of Mice with Gestational Diabetes Mellitus |
| title_full | Impact of Sucrose Consumption on the Metabolic, Immune, and Redox Profile of Mice with Gestational Diabetes Mellitus |
| title_fullStr | Impact of Sucrose Consumption on the Metabolic, Immune, and Redox Profile of Mice with Gestational Diabetes Mellitus |
| title_full_unstemmed | Impact of Sucrose Consumption on the Metabolic, Immune, and Redox Profile of Mice with Gestational Diabetes Mellitus |
| title_short | Impact of Sucrose Consumption on the Metabolic, Immune, and Redox Profile of Mice with Gestational Diabetes Mellitus |
| title_sort | impact of sucrose consumption on the metabolic immune and redox profile of mice with gestational diabetes mellitus |
| topic | gestational diabetes mellitus sucrose immune response redox mechanisms |
| url | https://www.mdpi.com/2075-1729/15/7/989 |
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