Tumor fluorescence and oxygenation monitoring during photodynamic therapy with chlorin e6 photosensitizer
Background: The study is aimed at developing a method for monitoring photodynamic therapy (PDT) of a tumor using chlorin-type photosensitizers (PSs). Lack of monitoring of chlorin e6 (Cе6) photobleaching, hemoglobin oxygenation and blood flow during light exposure can limit the PDT effectiveness. Ma...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024000085 |
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| author | Kanamat Efendiev Polina Alekseeva Kirill Linkov Artem Shiryaev Tatiana Pisareva Aida Gilyadova Igor Reshetov Arina Voitova Victor Loschenov |
| author_facet | Kanamat Efendiev Polina Alekseeva Kirill Linkov Artem Shiryaev Tatiana Pisareva Aida Gilyadova Igor Reshetov Arina Voitova Victor Loschenov |
| author_sort | Kanamat Efendiev |
| collection | DOAJ |
| description | Background: The study is aimed at developing a method for monitoring photodynamic therapy (PDT) of a tumor using chlorin-type photosensitizers (PSs). Lack of monitoring of chlorin e6 (Cе6) photobleaching, hemoglobin oxygenation and blood flow during light exposure can limit the PDT effectiveness. Materials and methods: Phototheranostics includes spectral-fluorescence diagnostics of Ce6 distribution in the NIR range and PDT with simultaneous assessment of hemoglobin oxygenation and tumor blood flow. Fluorescence diagnostics and PDT were performed using the single laser λexc=660 ± 5 nm. Results: Combined spectroscopic PDT monitoring method allowed simultaneous estimation of Ce6 photobleaching, hemoglobin oxygenation and tumor vascular thrombosis during PDT without interrupting the therapeutic light exposure. Conclusion: The developed method of tumor phototheranostics using chlorin-type PSs may make it possible to personalize the duration of therapeutic light exposure during PDT. |
| format | Article |
| id | doaj-art-31d7fc8834f345678608c4e2d06efa85 |
| institution | DOAJ |
| issn | 1572-1000 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-31d7fc8834f345678608c4e2d06efa852025-08-20T02:50:05ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002024-02-014510396910.1016/j.pdpdt.2024.103969Tumor fluorescence and oxygenation monitoring during photodynamic therapy with chlorin e6 photosensitizerKanamat Efendiev0Polina Alekseeva1Kirill Linkov2Artem Shiryaev3Tatiana Pisareva4Aida Gilyadova5Igor Reshetov6Arina Voitova7Victor Loschenov8Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia; National Research Nuclear University “MEPhI”, Moscow, Russia; Corresponding author at: Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia.Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow, RussiaProkhorov General Physics Institute of the Russian Academy of Sciences, Moscow, RussiaSechenov First Moscow State Medical University, Moscow, RussiaSechenov First Moscow State Medical University, Moscow, RussiaSechenov First Moscow State Medical University, Moscow, RussiaSechenov First Moscow State Medical University, Moscow, RussiaBIOSPEC Ltd., Moscow, RussiaProkhorov General Physics Institute of the Russian Academy of Sciences, Moscow, Russia; National Research Nuclear University “MEPhI”, Moscow, RussiaBackground: The study is aimed at developing a method for monitoring photodynamic therapy (PDT) of a tumor using chlorin-type photosensitizers (PSs). Lack of monitoring of chlorin e6 (Cе6) photobleaching, hemoglobin oxygenation and blood flow during light exposure can limit the PDT effectiveness. Materials and methods: Phototheranostics includes spectral-fluorescence diagnostics of Ce6 distribution in the NIR range and PDT with simultaneous assessment of hemoglobin oxygenation and tumor blood flow. Fluorescence diagnostics and PDT were performed using the single laser λexc=660 ± 5 nm. Results: Combined spectroscopic PDT monitoring method allowed simultaneous estimation of Ce6 photobleaching, hemoglobin oxygenation and tumor vascular thrombosis during PDT without interrupting the therapeutic light exposure. Conclusion: The developed method of tumor phototheranostics using chlorin-type PSs may make it possible to personalize the duration of therapeutic light exposure during PDT.http://www.sciencedirect.com/science/article/pii/S1572100024000085PhototheranosticsPhotodynamic therapyFluorescence diagnosticsPhotobleachingHemoglobin oxygenationVascular thrombosis |
| spellingShingle | Kanamat Efendiev Polina Alekseeva Kirill Linkov Artem Shiryaev Tatiana Pisareva Aida Gilyadova Igor Reshetov Arina Voitova Victor Loschenov Tumor fluorescence and oxygenation monitoring during photodynamic therapy with chlorin e6 photosensitizer Photodiagnosis and Photodynamic Therapy Phototheranostics Photodynamic therapy Fluorescence diagnostics Photobleaching Hemoglobin oxygenation Vascular thrombosis |
| title | Tumor fluorescence and oxygenation monitoring during photodynamic therapy with chlorin e6 photosensitizer |
| title_full | Tumor fluorescence and oxygenation monitoring during photodynamic therapy with chlorin e6 photosensitizer |
| title_fullStr | Tumor fluorescence and oxygenation monitoring during photodynamic therapy with chlorin e6 photosensitizer |
| title_full_unstemmed | Tumor fluorescence and oxygenation monitoring during photodynamic therapy with chlorin e6 photosensitizer |
| title_short | Tumor fluorescence and oxygenation monitoring during photodynamic therapy with chlorin e6 photosensitizer |
| title_sort | tumor fluorescence and oxygenation monitoring during photodynamic therapy with chlorin e6 photosensitizer |
| topic | Phototheranostics Photodynamic therapy Fluorescence diagnostics Photobleaching Hemoglobin oxygenation Vascular thrombosis |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024000085 |
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