Long-term aerobic exercise improves learning memory capacity and effects on oxidative stress levels and Keap1/Nrf2/GPX4 pathway in the hippocampus of APP/PS1 mice

Long-term aerobic exercise improves learning memory capacity and effects on oxidative stress levels and Keap1/Nrf2/GPX4 pathway in the hippocampus of APP/PS1 mice

ObjectiveTo examine the effects of long-term aerobic exercise on oxidative stress and learning memory ability of APP/PS1 mice, focusing on the hippocampal Keap1, Nrf2, HO-1, and GPX4 proteins.MethodsThirty APP/PS1 double transgenic AD mice were randomly divided into three groups: model group, short-...

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Bibliographic Details
Main Authors: Shiyan Wang, Ye Zhou, Yucheng Wu, Yali Lang, Yajun Mao, Guoyuan Pan, Zhenzhen Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer’s disease
aerobic exercise
oxidative stress
Nrf2
hippocampus
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1505650/full
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