Histopathological and immunohistochemical investigation of mammary tumors in female cats in Northeast Algeria
Cancer is a leading cause of feline mortality globally. This study focuses on delineating mammary gland tumor prevalence and anatomopathological characteristics in cats from northeastern Algeria. Encompassing the period from January 2021 to March 2022, the research included 50 cats from Constantine...
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Institute of Animal Biology NAAS
2024-10-01
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| Series: | Біологія тварин |
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| Online Access: | https://aminbiol.com.ua/index.php/archive/207-archive/bt-26-3-2024/2158-histopathological-and-immunohistochemical-investigation-of-mammary-tumors-in-female-cats-in-northeast-algeria |
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| author | Zahra Gabli Zouhir Djerrou Leila Beddar |
| author_facet | Zahra Gabli Zouhir Djerrou Leila Beddar |
| author_sort | Zahra Gabli |
| collection | DOAJ |
| description | Cancer is a leading cause of feline mortality globally. This study focuses on delineating mammary gland tumor prevalence and anatomopathological characteristics in cats from northeastern Algeria. Encompassing the period from January 2021 to March 2022, the research included 50 cats from Constantine and Annaba provinces, revealing an overall 20% feline mammary tumors (FMT) prevalence. Siamese cats exhibited a higher rate compared to crossbred cats, with a mean age of positively diagnosed cats at 9±0.3 years. Histopathological classification identified 20% of tumors as malignant, specifically squamous cell carcinoma, cribriform carcinoma, and comedocarcinoma. In conclusion, further epidemiological investigations are essential to understand the risk factors in the initiation and progression of these health issues. In contrast to canine species, FMTs are less diverse, predominantly simple malignant tumors. Benign FMTs are infrequent, and the existence of complex and mixed tumors in felines remains unclear. This study selected three FMT types for immunohistochemical analyses, revealing unusual histological characteristics. A set of three malignant tumors exhibited an epithelial/myoepithelial population, with consistent myoepithelial immunohistochemical signatures. All Grade I malignant tumors resulted in subjects surviving one-year post-diagnosis. Morphologically, we propose categorizing them as feline ductal/canalicular adenoma/carcinoma and feline intracanalicular papillary adenoma/carcinoma, respectively. These findings contribute novel insights to FMT classification and are valuable for prognostic studies. |
| format | Article |
| id | doaj-art-31cebeeb531d4a5eb873ee0fa137168c |
| institution | DOAJ |
| issn | 1681-0015 2313-2191 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Institute of Animal Biology NAAS |
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| series | Біологія тварин |
| spelling | doaj-art-31cebeeb531d4a5eb873ee0fa137168c2025-08-20T03:13:29ZengInstitute of Animal Biology NAASБіологія тварин1681-00152313-21912024-10-0126331310.15407/animbiol26.03.003Histopathological and immunohistochemical investigation of mammary tumors in female cats in Northeast AlgeriaZahra Gabli0https://orcid.org/0000-0002-9724-5228Zouhir Djerrou1https://orcid.org/0000-0001-8329-5868Leila Beddar2University of August 20th 1955, Faculty of Sciences, Natural and Life Sciences DepartmentUniversity of August 20th 1955, Faculty of Sciences, Natural and Life Sciences DepartmentBen Badis University Hospital CenterCancer is a leading cause of feline mortality globally. This study focuses on delineating mammary gland tumor prevalence and anatomopathological characteristics in cats from northeastern Algeria. Encompassing the period from January 2021 to March 2022, the research included 50 cats from Constantine and Annaba provinces, revealing an overall 20% feline mammary tumors (FMT) prevalence. Siamese cats exhibited a higher rate compared to crossbred cats, with a mean age of positively diagnosed cats at 9±0.3 years. Histopathological classification identified 20% of tumors as malignant, specifically squamous cell carcinoma, cribriform carcinoma, and comedocarcinoma. In conclusion, further epidemiological investigations are essential to understand the risk factors in the initiation and progression of these health issues. In contrast to canine species, FMTs are less diverse, predominantly simple malignant tumors. Benign FMTs are infrequent, and the existence of complex and mixed tumors in felines remains unclear. This study selected three FMT types for immunohistochemical analyses, revealing unusual histological characteristics. A set of three malignant tumors exhibited an epithelial/myoepithelial population, with consistent myoepithelial immunohistochemical signatures. All Grade I malignant tumors resulted in subjects surviving one-year post-diagnosis. Morphologically, we propose categorizing them as feline ductal/canalicular adenoma/carcinoma and feline intracanalicular papillary adenoma/carcinoma, respectively. These findings contribute novel insights to FMT classification and are valuable for prognostic studies.https://aminbiol.com.ua/index.php/archive/207-archive/bt-26-3-2024/2158-histopathological-and-immunohistochemical-investigation-of-mammary-tumors-in-female-cats-in-northeast-algeriamammary tumorsfemale catnortheast algeriahistopathological investigationimmunohistochemical analysisпухлини молочної залозикішкапівнічно-східний алжирпатогістологічне дослідженняімуногістохімічний аналіз |
| spellingShingle | Zahra Gabli Zouhir Djerrou Leila Beddar Histopathological and immunohistochemical investigation of mammary tumors in female cats in Northeast Algeria Біологія тварин mammary tumors female cat northeast algeria histopathological investigation immunohistochemical analysis пухлини молочної залози кішка північно-східний алжир патогістологічне дослідження імуногістохімічний аналіз |
| title | Histopathological and immunohistochemical investigation of mammary tumors in female cats in Northeast Algeria |
| title_full | Histopathological and immunohistochemical investigation of mammary tumors in female cats in Northeast Algeria |
| title_fullStr | Histopathological and immunohistochemical investigation of mammary tumors in female cats in Northeast Algeria |
| title_full_unstemmed | Histopathological and immunohistochemical investigation of mammary tumors in female cats in Northeast Algeria |
| title_short | Histopathological and immunohistochemical investigation of mammary tumors in female cats in Northeast Algeria |
| title_sort | histopathological and immunohistochemical investigation of mammary tumors in female cats in northeast algeria |
| topic | mammary tumors female cat northeast algeria histopathological investigation immunohistochemical analysis пухлини молочної залози кішка північно-східний алжир патогістологічне дослідження імуногістохімічний аналіз |
| url | https://aminbiol.com.ua/index.php/archive/207-archive/bt-26-3-2024/2158-histopathological-and-immunohistochemical-investigation-of-mammary-tumors-in-female-cats-in-northeast-algeria |
| work_keys_str_mv | AT zahragabli histopathologicalandimmunohistochemicalinvestigationofmammarytumorsinfemalecatsinnortheastalgeria AT zouhirdjerrou histopathologicalandimmunohistochemicalinvestigationofmammarytumorsinfemalecatsinnortheastalgeria AT leilabeddar histopathologicalandimmunohistochemicalinvestigationofmammarytumorsinfemalecatsinnortheastalgeria |