Heavy Metal-Induced Oxidative DNA Damage in Earthworms: A Review
Earthworms can be used as a bio-indicator of metal contamination in soil, Earlier reports claimed the bioaccumulation of heavy metals in earthworm tissues, while the metal-induced mutagenicity reared in contaminated soils for long duration. But we examined the metal-induced mutagenicity in earthworm...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Applied and Environmental Soil Science |
| Online Access: | http://dx.doi.org/10.1155/2010/726946 |
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| _version_ | 1850218619273740288 |
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| author | Takeshi Hirano Kazuyoshi Tamae |
| author_facet | Takeshi Hirano Kazuyoshi Tamae |
| author_sort | Takeshi Hirano |
| collection | DOAJ |
| description | Earthworms can be used as a bio-indicator of metal contamination in soil, Earlier reports claimed the bioaccumulation of heavy metals in earthworm tissues, while the metal-induced mutagenicity reared in contaminated soils for long duration. But we examined the metal-induced mutagenicity in earthworms reared in metal containing culture beddings. In this experiment we observed the generation of 8-oxoguanine (8-oxo-Gua) in earthworms exposed to cadmium and nickel in soil. 8-oxo-Gua is a major premutagenic form of oxidative DNA damage that induces GC-to-TA point mutations, leading to carcinogenesis. |
| format | Article |
| id | doaj-art-31ccd2f7b1ad4d3a8a1787635ed5137c |
| institution | OA Journals |
| issn | 1687-7667 1687-7675 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Applied and Environmental Soil Science |
| spelling | doaj-art-31ccd2f7b1ad4d3a8a1787635ed5137c2025-08-20T02:07:40ZengWileyApplied and Environmental Soil Science1687-76671687-76752010-01-01201010.1155/2010/726946726946Heavy Metal-Induced Oxidative DNA Damage in Earthworms: A ReviewTakeshi Hirano0Kazuyoshi Tamae1Department of Life and Environment Engineering, Faculty of Environmental Engineering, The University of Kitakyushu, Kitakyushu, Fukuoka 808-0135, JapanDivision of Teacher Training, Faculty of Education and Culture, University of Miyazaki, Miyazaki 889-2192, JapanEarthworms can be used as a bio-indicator of metal contamination in soil, Earlier reports claimed the bioaccumulation of heavy metals in earthworm tissues, while the metal-induced mutagenicity reared in contaminated soils for long duration. But we examined the metal-induced mutagenicity in earthworms reared in metal containing culture beddings. In this experiment we observed the generation of 8-oxoguanine (8-oxo-Gua) in earthworms exposed to cadmium and nickel in soil. 8-oxo-Gua is a major premutagenic form of oxidative DNA damage that induces GC-to-TA point mutations, leading to carcinogenesis.http://dx.doi.org/10.1155/2010/726946 |
| spellingShingle | Takeshi Hirano Kazuyoshi Tamae Heavy Metal-Induced Oxidative DNA Damage in Earthworms: A Review Applied and Environmental Soil Science |
| title | Heavy Metal-Induced Oxidative DNA Damage in Earthworms: A Review |
| title_full | Heavy Metal-Induced Oxidative DNA Damage in Earthworms: A Review |
| title_fullStr | Heavy Metal-Induced Oxidative DNA Damage in Earthworms: A Review |
| title_full_unstemmed | Heavy Metal-Induced Oxidative DNA Damage in Earthworms: A Review |
| title_short | Heavy Metal-Induced Oxidative DNA Damage in Earthworms: A Review |
| title_sort | heavy metal induced oxidative dna damage in earthworms a review |
| url | http://dx.doi.org/10.1155/2010/726946 |
| work_keys_str_mv | AT takeshihirano heavymetalinducedoxidativednadamageinearthwormsareview AT kazuyoshitamae heavymetalinducedoxidativednadamageinearthwormsareview |