Incremental Peritoneal Dialysis Favourably Compares with Hemodialysis as a Bridge to Renal Transplantation
Background. The value of incremental peritoneal dialysis (PD) as a bridge to renal transplantation (Tx) has not been specifically addressed. Methods. All consecutive Stage 5 CKD patients with at least 1 year predialysis followup, starting incremental PD or HD under our care and subsequently receivin...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.4061/2011/204216 |
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| author | Alessandro Domenici Maria Cristina Comunian Loredana Fazzari Francesca Sivo Angela Dinnella Barbara Della Grotta Giorgio Punzo Paolo Menè |
| author_facet | Alessandro Domenici Maria Cristina Comunian Loredana Fazzari Francesca Sivo Angela Dinnella Barbara Della Grotta Giorgio Punzo Paolo Menè |
| author_sort | Alessandro Domenici |
| collection | DOAJ |
| description | Background. The value of incremental peritoneal dialysis (PD) as a bridge to renal transplantation (Tx) has not been specifically addressed.
Methods. All consecutive Stage 5 CKD patients with at least 1 year predialysis followup, starting incremental PD or HD under our care and subsequently receiving their first renal Tx were included in this observational cohort study. Age, gender, BMI, underlying nephropathy, residual renal function (RRF) loss rate before dialysis and RRF at RRT start, comorbidity, RRT schedules and adequacy measures, dialysis-related morbidity, Tx waiting time, RRF at Tx, incidence of delayed graft function (DGF), in-hospital stay for Tx, serum creatinine at discharge and one year later were collected and compared between patients on incremental PD or HD before Tx.
Results. Seventeen patients on incremental PD and 24 on HD received their first renal Tx during the study period. Age, underlying nephropathy, RRF loss rate in predialysis, RRF at the start of RRT and comorbidity did not differ significantly. While on dialysis, patients on PD had significantly lower epoetin requirements, serum phosphate, calciumxphosphate product and better RRF preservation. Delayed graft function (DGF) occurred in 12 patients (29%), 1 on incremental PD and 11 on HD. Serum creatinine at discharge and 1 year later was significantly higher in patients who had been on HD.
Conclusions. In patients receiving their first renal Tx, previous incremental PD was associated with low morbidity, excellent preservation of RRF, easier attainment of adequacy targets and significantly better immediate and 1-year graft function than those observed in otherwise well-matched patients previously treated with HD. |
| format | Article |
| id | doaj-art-31c82a8adbac41f486690920452f5250 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-31c82a8adbac41f486690920452f52502025-02-03T05:43:45ZengWileyInternational Journal of Nephrology2090-214X2090-21582011-01-01201110.4061/2011/204216204216Incremental Peritoneal Dialysis Favourably Compares with Hemodialysis as a Bridge to Renal TransplantationAlessandro Domenici0Maria Cristina Comunian1Loredana Fazzari2Francesca Sivo3Angela Dinnella4Barbara Della Grotta5Giorgio Punzo6Paolo Menè7Nephrology and Dialysis Unit, Department of Cardiovascular, Renal and Pulmonary Diseases, Sant'Andrea Hospital, Sapienza University of Rome, 00189 Rome, ItalyNephrology and Dialysis Unit, Department of Cardiovascular, Renal and Pulmonary Diseases, Sant'Andrea Hospital, Sapienza University of Rome, 00189 Rome, ItalyNephrology and Dialysis Unit, Department of Cardiovascular, Renal and Pulmonary Diseases, Sant'Andrea Hospital, Sapienza University of Rome, 00189 Rome, ItalyNephrology and Dialysis Unit, Department of Cardiovascular, Renal and Pulmonary Diseases, Sant'Andrea Hospital, Sapienza University of Rome, 00189 Rome, ItalyPeritoneal Dialysis Regional Referral Centre, Nephrology and Dialysis Unit, Civic Hospital, 00042 Anzio, ItalyPeritoneal Dialysis Regional Referral Centre, Nephrology and Dialysis Unit, Civic Hospital, 00042 Anzio, ItalyNephrology and Dialysis Unit, Department of Cardiovascular, Renal and Pulmonary Diseases, Sant'Andrea Hospital, Sapienza University of Rome, 00189 Rome, ItalyNephrology and Dialysis Unit, Department of Cardiovascular, Renal and Pulmonary Diseases, Sant'Andrea Hospital, Sapienza University of Rome, 00189 Rome, ItalyBackground. The value of incremental peritoneal dialysis (PD) as a bridge to renal transplantation (Tx) has not been specifically addressed. Methods. All consecutive Stage 5 CKD patients with at least 1 year predialysis followup, starting incremental PD or HD under our care and subsequently receiving their first renal Tx were included in this observational cohort study. Age, gender, BMI, underlying nephropathy, residual renal function (RRF) loss rate before dialysis and RRF at RRT start, comorbidity, RRT schedules and adequacy measures, dialysis-related morbidity, Tx waiting time, RRF at Tx, incidence of delayed graft function (DGF), in-hospital stay for Tx, serum creatinine at discharge and one year later were collected and compared between patients on incremental PD or HD before Tx. Results. Seventeen patients on incremental PD and 24 on HD received their first renal Tx during the study period. Age, underlying nephropathy, RRF loss rate in predialysis, RRF at the start of RRT and comorbidity did not differ significantly. While on dialysis, patients on PD had significantly lower epoetin requirements, serum phosphate, calciumxphosphate product and better RRF preservation. Delayed graft function (DGF) occurred in 12 patients (29%), 1 on incremental PD and 11 on HD. Serum creatinine at discharge and 1 year later was significantly higher in patients who had been on HD. Conclusions. In patients receiving their first renal Tx, previous incremental PD was associated with low morbidity, excellent preservation of RRF, easier attainment of adequacy targets and significantly better immediate and 1-year graft function than those observed in otherwise well-matched patients previously treated with HD.http://dx.doi.org/10.4061/2011/204216 |
| spellingShingle | Alessandro Domenici Maria Cristina Comunian Loredana Fazzari Francesca Sivo Angela Dinnella Barbara Della Grotta Giorgio Punzo Paolo Menè Incremental Peritoneal Dialysis Favourably Compares with Hemodialysis as a Bridge to Renal Transplantation International Journal of Nephrology |
| title | Incremental Peritoneal Dialysis Favourably Compares with Hemodialysis as a Bridge to Renal Transplantation |
| title_full | Incremental Peritoneal Dialysis Favourably Compares with Hemodialysis as a Bridge to Renal Transplantation |
| title_fullStr | Incremental Peritoneal Dialysis Favourably Compares with Hemodialysis as a Bridge to Renal Transplantation |
| title_full_unstemmed | Incremental Peritoneal Dialysis Favourably Compares with Hemodialysis as a Bridge to Renal Transplantation |
| title_short | Incremental Peritoneal Dialysis Favourably Compares with Hemodialysis as a Bridge to Renal Transplantation |
| title_sort | incremental peritoneal dialysis favourably compares with hemodialysis as a bridge to renal transplantation |
| url | http://dx.doi.org/10.4061/2011/204216 |
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