Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus
Purpose. To investigate the impact of disease duration on the ocular surface during the course of type 2 diabetes mellitus compared with nondiabetic controls. Methods. One hundred twenty diabetic patients were divided into three groups according to disease duration: less than 5 years, 5–10 years, an...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2018/1206808 |
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| _version_ | 1849306629703467008 |
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| author | Fanglin He Zhanlin Zhao Yan Liu Linna Lu Yao Fu |
| author_facet | Fanglin He Zhanlin Zhao Yan Liu Linna Lu Yao Fu |
| author_sort | Fanglin He |
| collection | DOAJ |
| description | Purpose. To investigate the impact of disease duration on the ocular surface during the course of type 2 diabetes mellitus compared with nondiabetic controls. Methods. One hundred twenty diabetic patients were divided into three groups according to disease duration: less than 5 years, 5–10 years, and over 10 years. All eyes were imaged using a corneal topographer (Oculus Keratograph 5M). Tear film measurements and meibography were also recorded. Meibomian gland changes were scored from 0 to 6 (meiboscore). Results. The noninvasive breakup time first (NIKBUT-1st) and noninvasive breakup time average (NIKBUT-avg) were significantly shorter in the over 10 years diabetic group compared with the control group (P=0.0056 and P=0.010, resp.). Tear meniscus height (TMH) was significantly lower in the over 10 years diabetic group compared with the control group (P=0.0016) and the 5 years group (P=0.0061). We also found that more patients in the over 10 years diabetic group showed bulbar and limbal hyperemia compared with the control group (bulbar hyperemia: P=0.049; limbal hyperemia: P=0.026). The meiboscore in the over 10 years diabetic group was significantly higher compared with the other three groups (P<0.05). Bulbar hyperemia showed a significant negative correlation with NIKBUT-1st in the over 10 years diabetic group (r=−0.35 and P<0.05). Conclusion. Ocular surface damage in long-term type 2 diabetes is more severe than that in patients with shorter disease duration. |
| format | Article |
| id | doaj-art-31c3834ccacf4a2f93361302ef1b27fc |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-31c3834ccacf4a2f93361302ef1b27fc2025-08-20T03:55:01ZengWileyJournal of Ophthalmology2090-004X2090-00582018-01-01201810.1155/2018/12068081206808Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes MellitusFanglin He0Zhanlin Zhao1Yan Liu2Linna Lu3Yao Fu4Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, ChinaPurpose. To investigate the impact of disease duration on the ocular surface during the course of type 2 diabetes mellitus compared with nondiabetic controls. Methods. One hundred twenty diabetic patients were divided into three groups according to disease duration: less than 5 years, 5–10 years, and over 10 years. All eyes were imaged using a corneal topographer (Oculus Keratograph 5M). Tear film measurements and meibography were also recorded. Meibomian gland changes were scored from 0 to 6 (meiboscore). Results. The noninvasive breakup time first (NIKBUT-1st) and noninvasive breakup time average (NIKBUT-avg) were significantly shorter in the over 10 years diabetic group compared with the control group (P=0.0056 and P=0.010, resp.). Tear meniscus height (TMH) was significantly lower in the over 10 years diabetic group compared with the control group (P=0.0016) and the 5 years group (P=0.0061). We also found that more patients in the over 10 years diabetic group showed bulbar and limbal hyperemia compared with the control group (bulbar hyperemia: P=0.049; limbal hyperemia: P=0.026). The meiboscore in the over 10 years diabetic group was significantly higher compared with the other three groups (P<0.05). Bulbar hyperemia showed a significant negative correlation with NIKBUT-1st in the over 10 years diabetic group (r=−0.35 and P<0.05). Conclusion. Ocular surface damage in long-term type 2 diabetes is more severe than that in patients with shorter disease duration.http://dx.doi.org/10.1155/2018/1206808 |
| spellingShingle | Fanglin He Zhanlin Zhao Yan Liu Linna Lu Yao Fu Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus Journal of Ophthalmology |
| title | Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus |
| title_full | Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus |
| title_fullStr | Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus |
| title_full_unstemmed | Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus |
| title_short | Assessment of Ocular Surface Damage during the Course of Type 2 Diabetes Mellitus |
| title_sort | assessment of ocular surface damage during the course of type 2 diabetes mellitus |
| url | http://dx.doi.org/10.1155/2018/1206808 |
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