Cerebrospinal fluid-contacting neurons: a promising source for adult neural stem cell transplantation in spinal cord injury treatment
Transplantation of adult neural stem cells (NSCs) is regarded as one of the most promising approaches for treating spinal cord injury (SCI). However, securing a sufficient and reliable source of adult NSCs remains one of the primary challenges in applying this method for SCI treatment. Cerebrospinal...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-03-01
|
| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1549194/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850228622971895808 |
|---|---|
| author | Zhangrong Luo Zhangrong Luo Zeyu Shangguan Zeyu Shangguan Liang Cao Liang Cao Yi Zhang Yi Zhang Qizhe Li Qizhe Li Xuexing Shi Xuexing Shi Jiangquan Fu Jiangquan Fu Chunqing Wang Xiaowei Dou Wei Tan Wei Tan Qing Li |
| author_facet | Zhangrong Luo Zhangrong Luo Zeyu Shangguan Zeyu Shangguan Liang Cao Liang Cao Yi Zhang Yi Zhang Qizhe Li Qizhe Li Xuexing Shi Xuexing Shi Jiangquan Fu Jiangquan Fu Chunqing Wang Xiaowei Dou Wei Tan Wei Tan Qing Li |
| author_sort | Zhangrong Luo |
| collection | DOAJ |
| description | Transplantation of adult neural stem cells (NSCs) is regarded as one of the most promising approaches for treating spinal cord injury (SCI). However, securing a sufficient and reliable source of adult NSCs remains one of the primary challenges in applying this method for SCI treatment. Cerebrospinal fluid-contacting neurons (CSF-cNs) act as adult NSCs and can be substantially expanded in vitro while maintaining their NSC characteristics even after 60 passages. When CSF-cNs are transplanted into the injury sites of SCI mice, they demonstrate high survival rates along with the ability to proliferate and differentiate into neurons, astrocytes, and oligodendrocytes. Additionally, significant improvements in motor function have been observed in SCI mice following the transplantation of CSF-cNs. These results suggest that CSF-cNs may represent a promising source of adult NSCs for transplantation therapy in SCI. |
| format | Article |
| id | doaj-art-31c06abab5994b398d4f5fc0dddeb39c |
| institution | OA Journals |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-31c06abab5994b398d4f5fc0dddeb39c2025-08-20T02:04:28ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-03-011310.3389/fcell.2025.15491941549194Cerebrospinal fluid-contacting neurons: a promising source for adult neural stem cell transplantation in spinal cord injury treatmentZhangrong Luo0Zhangrong Luo1Zeyu Shangguan2Zeyu Shangguan3Liang Cao4Liang Cao5Yi Zhang6Yi Zhang7Qizhe Li8Qizhe Li9Xuexing Shi10Xuexing Shi11Jiangquan Fu12Jiangquan Fu13Chunqing Wang14Xiaowei Dou15Wei Tan16Wei Tan17Qing Li18Department of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Traumatic Orthopedics, The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaSchool of Clinical Medicine, Guizhou Medical University, Guiyang, ChinaDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaSchool of Clinical Medicine, Guizhou Medical University, Guiyang, ChinaDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaSchool of Clinical Medicine, Guizhou Medical University, Guiyang, ChinaDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaSchool of Clinical Medicine, Guizhou Medical University, Guiyang, ChinaDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaSchool of Clinical Medicine, Guizhou Medical University, Guiyang, ChinaDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaSchool of Clinical Medicine, Guizhou Medical University, Guiyang, ChinaDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaClinical Research Center, Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaSchool of Clinical Medicine, Guizhou Medical University, Guiyang, ChinaDepartment of Emergency, The Affiliated Hospital of Guizhou Medical University, Guiyang, ChinaTransplantation of adult neural stem cells (NSCs) is regarded as one of the most promising approaches for treating spinal cord injury (SCI). However, securing a sufficient and reliable source of adult NSCs remains one of the primary challenges in applying this method for SCI treatment. Cerebrospinal fluid-contacting neurons (CSF-cNs) act as adult NSCs and can be substantially expanded in vitro while maintaining their NSC characteristics even after 60 passages. When CSF-cNs are transplanted into the injury sites of SCI mice, they demonstrate high survival rates along with the ability to proliferate and differentiate into neurons, astrocytes, and oligodendrocytes. Additionally, significant improvements in motor function have been observed in SCI mice following the transplantation of CSF-cNs. These results suggest that CSF-cNs may represent a promising source of adult NSCs for transplantation therapy in SCI.https://www.frontiersin.org/articles/10.3389/fcell.2025.1549194/fullneural stem cellscerebrospinal fluid-contacting neurons (CSF-cNs)spinal cord injury (SCI)cell transplantation therapymotor function recovery |
| spellingShingle | Zhangrong Luo Zhangrong Luo Zeyu Shangguan Zeyu Shangguan Liang Cao Liang Cao Yi Zhang Yi Zhang Qizhe Li Qizhe Li Xuexing Shi Xuexing Shi Jiangquan Fu Jiangquan Fu Chunqing Wang Xiaowei Dou Wei Tan Wei Tan Qing Li Cerebrospinal fluid-contacting neurons: a promising source for adult neural stem cell transplantation in spinal cord injury treatment Frontiers in Cell and Developmental Biology neural stem cells cerebrospinal fluid-contacting neurons (CSF-cNs) spinal cord injury (SCI) cell transplantation therapy motor function recovery |
| title | Cerebrospinal fluid-contacting neurons: a promising source for adult neural stem cell transplantation in spinal cord injury treatment |
| title_full | Cerebrospinal fluid-contacting neurons: a promising source for adult neural stem cell transplantation in spinal cord injury treatment |
| title_fullStr | Cerebrospinal fluid-contacting neurons: a promising source for adult neural stem cell transplantation in spinal cord injury treatment |
| title_full_unstemmed | Cerebrospinal fluid-contacting neurons: a promising source for adult neural stem cell transplantation in spinal cord injury treatment |
| title_short | Cerebrospinal fluid-contacting neurons: a promising source for adult neural stem cell transplantation in spinal cord injury treatment |
| title_sort | cerebrospinal fluid contacting neurons a promising source for adult neural stem cell transplantation in spinal cord injury treatment |
| topic | neural stem cells cerebrospinal fluid-contacting neurons (CSF-cNs) spinal cord injury (SCI) cell transplantation therapy motor function recovery |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1549194/full |
| work_keys_str_mv | AT zhangrongluo cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment AT zhangrongluo cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment AT zeyushangguan cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment AT zeyushangguan cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment AT liangcao cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment AT liangcao cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment AT yizhang cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment AT yizhang cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment AT qizheli cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment AT qizheli cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment AT xuexingshi cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment AT xuexingshi cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment AT jiangquanfu cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment AT jiangquanfu cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment AT chunqingwang cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment AT xiaoweidou cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment AT weitan cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment AT weitan cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment AT qingli cerebrospinalfluidcontactingneuronsapromisingsourceforadultneuralstemcelltransplantationinspinalcordinjurytreatment |