Examining the effect of salbutamol use in ozone air pollution by people with exercise‐induced bronchoconstriction
Abstract Previous studies based on animal models have raised concerns about salbutamol use in ozone air pollution with regard to ozone related lung injury. We conducted a double‐blind, randomized, placebo‐controlled crossover study including 18 subjects diagnosed with EIB by a eucapnic voluntary hyp...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-11-01
|
| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.70117 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832586707034177536 |
|---|---|
| author | Bennett T. Stothers Andy Hung Patric E. O. Gonçalves Lulu X. Pei Tessa van deKerkhof Jem I. Arnold Owen D. Harris Nadine Borduas‐Dedekind Andrew W. Sheel Michael S. Koehle |
| author_facet | Bennett T. Stothers Andy Hung Patric E. O. Gonçalves Lulu X. Pei Tessa van deKerkhof Jem I. Arnold Owen D. Harris Nadine Borduas‐Dedekind Andrew W. Sheel Michael S. Koehle |
| author_sort | Bennett T. Stothers |
| collection | DOAJ |
| description | Abstract Previous studies based on animal models have raised concerns about salbutamol use in ozone air pollution with regard to ozone related lung injury. We conducted a double‐blind, randomized, placebo‐controlled crossover study including 18 subjects diagnosed with EIB by a eucapnic voluntary hyperpnea (EVH) test. Participants completed 30 min of standardized moderate to vigorous exercise in four conditions: ozone plus salbutamol; room air plus salbutamol; ozone plus placebo medication; and room air plus placebo medication. Spirometry, fraction of exhaled nitric oxide, and symptoms were measured before, immediately after, 30 min after and 1 h after exercise. Measurements between the four conditions were compared using percent change from pre to post exercise. There was a statistically significant difference between the salbutamol and placebo medication groups for spirometric variables including FEV1 (Estimate = 6.3, 95% CI: 4.23–8.37, p < 0.001). No differences were observed between ozone and room air exposures. There were no significant differences in FeNO response between experimental conditions. We found that salbutamol improved pulmonary function in individuals with EIB when exercising in ozone and did not increase eosinophilic airway inflammation as indicated by FeNO. This evidence suggests that it is safe for people with EIB to continue to use salbutamol as prescribed when ozone levels are elevated. |
| format | Article |
| id | doaj-art-31b9e3d66c6b40fe8a7b17bbbc6fdb41 |
| institution | Kabale University |
| issn | 2051-817X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj-art-31b9e3d66c6b40fe8a7b17bbbc6fdb412025-01-25T06:41:00ZengWileyPhysiological Reports2051-817X2024-11-011221n/an/a10.14814/phy2.70117Examining the effect of salbutamol use in ozone air pollution by people with exercise‐induced bronchoconstrictionBennett T. Stothers0Andy Hung1Patric E. O. Gonçalves2Lulu X. Pei3Tessa van deKerkhof4Jem I. Arnold5Owen D. Harris6Nadine Borduas‐Dedekind7Andrew W. Sheel8Michael S. Koehle9University of British Columbia Vancouver CanadaUniversity of British Columbia Vancouver CanadaUniversity of British Columbia Vancouver CanadaUniversity of British Columbia Vancouver CanadaRadboud Universiteit Nijmegen The NetherlandsUniversity of British Columbia Vancouver CanadaUniversity of British Columbia Vancouver CanadaUniversity of British Columbia Vancouver CanadaUniversity of British Columbia Vancouver CanadaUniversity of British Columbia Vancouver CanadaAbstract Previous studies based on animal models have raised concerns about salbutamol use in ozone air pollution with regard to ozone related lung injury. We conducted a double‐blind, randomized, placebo‐controlled crossover study including 18 subjects diagnosed with EIB by a eucapnic voluntary hyperpnea (EVH) test. Participants completed 30 min of standardized moderate to vigorous exercise in four conditions: ozone plus salbutamol; room air plus salbutamol; ozone plus placebo medication; and room air plus placebo medication. Spirometry, fraction of exhaled nitric oxide, and symptoms were measured before, immediately after, 30 min after and 1 h after exercise. Measurements between the four conditions were compared using percent change from pre to post exercise. There was a statistically significant difference between the salbutamol and placebo medication groups for spirometric variables including FEV1 (Estimate = 6.3, 95% CI: 4.23–8.37, p < 0.001). No differences were observed between ozone and room air exposures. There were no significant differences in FeNO response between experimental conditions. We found that salbutamol improved pulmonary function in individuals with EIB when exercising in ozone and did not increase eosinophilic airway inflammation as indicated by FeNO. This evidence suggests that it is safe for people with EIB to continue to use salbutamol as prescribed when ozone levels are elevated.https://doi.org/10.14814/phy2.70117Airwayasthmaexercise |
| spellingShingle | Bennett T. Stothers Andy Hung Patric E. O. Gonçalves Lulu X. Pei Tessa van deKerkhof Jem I. Arnold Owen D. Harris Nadine Borduas‐Dedekind Andrew W. Sheel Michael S. Koehle Examining the effect of salbutamol use in ozone air pollution by people with exercise‐induced bronchoconstriction Physiological Reports Airway asthma exercise |
| title | Examining the effect of salbutamol use in ozone air pollution by people with exercise‐induced bronchoconstriction |
| title_full | Examining the effect of salbutamol use in ozone air pollution by people with exercise‐induced bronchoconstriction |
| title_fullStr | Examining the effect of salbutamol use in ozone air pollution by people with exercise‐induced bronchoconstriction |
| title_full_unstemmed | Examining the effect of salbutamol use in ozone air pollution by people with exercise‐induced bronchoconstriction |
| title_short | Examining the effect of salbutamol use in ozone air pollution by people with exercise‐induced bronchoconstriction |
| title_sort | examining the effect of salbutamol use in ozone air pollution by people with exercise induced bronchoconstriction |
| topic | Airway asthma exercise |
| url | https://doi.org/10.14814/phy2.70117 |
| work_keys_str_mv | AT bennetttstothers examiningtheeffectofsalbutamoluseinozoneairpollutionbypeoplewithexerciseinducedbronchoconstriction AT andyhung examiningtheeffectofsalbutamoluseinozoneairpollutionbypeoplewithexerciseinducedbronchoconstriction AT patriceogoncalves examiningtheeffectofsalbutamoluseinozoneairpollutionbypeoplewithexerciseinducedbronchoconstriction AT luluxpei examiningtheeffectofsalbutamoluseinozoneairpollutionbypeoplewithexerciseinducedbronchoconstriction AT tessavandekerkhof examiningtheeffectofsalbutamoluseinozoneairpollutionbypeoplewithexerciseinducedbronchoconstriction AT jemiarnold examiningtheeffectofsalbutamoluseinozoneairpollutionbypeoplewithexerciseinducedbronchoconstriction AT owendharris examiningtheeffectofsalbutamoluseinozoneairpollutionbypeoplewithexerciseinducedbronchoconstriction AT nadineborduasdedekind examiningtheeffectofsalbutamoluseinozoneairpollutionbypeoplewithexerciseinducedbronchoconstriction AT andrewwsheel examiningtheeffectofsalbutamoluseinozoneairpollutionbypeoplewithexerciseinducedbronchoconstriction AT michaelskoehle examiningtheeffectofsalbutamoluseinozoneairpollutionbypeoplewithexerciseinducedbronchoconstriction |