Evaluation the anticancer and biological activity by new amide compound of trimethoprim with some of its complexes
By reacting trimethoprim and hippuric acid at a molecular weight of 1, the amide ligand molecule was produced. By reacting ligands with CoCl2.2H2O, NiCl2.6H2O, and K2PtCl6 in a 2:1 [L:M] mole ratio, cobalt (II), nickel (II), and platinum (IV) complexes were produced. All of the produced compounds we...
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University of Guilan
2024-01-01
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| Series: | Caspian Journal of Environmental Sciences |
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| Online Access: | https://cjes.guilan.ac.ir/article_7323_ec2b0892f63ff84c279a68093026e5e1.pdf |
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| author | Alaa Abdullah Majeed Asmaa Mohammed Noori Khaleel |
| author_facet | Alaa Abdullah Majeed Asmaa Mohammed Noori Khaleel |
| author_sort | Alaa Abdullah Majeed |
| collection | DOAJ |
| description | By reacting trimethoprim and hippuric acid at a molecular weight of 1, the amide ligand molecule was produced. By reacting ligands with CoCl2.2H2O, NiCl2.6H2O, and K2PtCl6 in a 2:1 [L:M] mole ratio, cobalt (II), nickel (II), and platinum (IV) complexes were produced. All of the produced compounds were studied by taking readings of their FT-IR, UV-Vis, TG/DTA, 1H-NMR, CHN, melting point, molar conductivity, magnetic susceptibility, and chloride. All the synthesized compounds had anticancer, antibacterial, and antifungal activities against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida, respectively. |
| format | Article |
| id | doaj-art-31b68ba329344e21838b511ac5a1ed37 |
| institution | OA Journals |
| issn | 1735-3033 1735-3866 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | University of Guilan |
| record_format | Article |
| series | Caspian Journal of Environmental Sciences |
| spelling | doaj-art-31b68ba329344e21838b511ac5a1ed372025-08-20T01:57:08ZengUniversity of GuilanCaspian Journal of Environmental Sciences1735-30331735-38662024-01-0122192210.22124/cjes.2023.73237323Evaluation the anticancer and biological activity by new amide compound of trimethoprim with some of its complexesAlaa Abdullah Majeed0Asmaa Mohammed Noori Khaleel1Department of Chemistry, College of Science, University of Baghdad, Baghdad, IraqDepartment of Chemistry, College of Science, University of Baghdad, Baghdad, IraqBy reacting trimethoprim and hippuric acid at a molecular weight of 1, the amide ligand molecule was produced. By reacting ligands with CoCl2.2H2O, NiCl2.6H2O, and K2PtCl6 in a 2:1 [L:M] mole ratio, cobalt (II), nickel (II), and platinum (IV) complexes were produced. All of the produced compounds were studied by taking readings of their FT-IR, UV-Vis, TG/DTA, 1H-NMR, CHN, melting point, molar conductivity, magnetic susceptibility, and chloride. All the synthesized compounds had anticancer, antibacterial, and antifungal activities against Staphylococcus aureus, Pseudomonas aeruginosa, and Candida, respectively.https://cjes.guilan.ac.ir/article_7323_ec2b0892f63ff84c279a68093026e5e1.pdfdrugtrimethoprimamide structurehippuric acidanticancer |
| spellingShingle | Alaa Abdullah Majeed Asmaa Mohammed Noori Khaleel Evaluation the anticancer and biological activity by new amide compound of trimethoprim with some of its complexes Caspian Journal of Environmental Sciences drug trimethoprim amide structure hippuric acid anticancer |
| title | Evaluation the anticancer and biological activity by new amide compound of trimethoprim with some of its complexes |
| title_full | Evaluation the anticancer and biological activity by new amide compound of trimethoprim with some of its complexes |
| title_fullStr | Evaluation the anticancer and biological activity by new amide compound of trimethoprim with some of its complexes |
| title_full_unstemmed | Evaluation the anticancer and biological activity by new amide compound of trimethoprim with some of its complexes |
| title_short | Evaluation the anticancer and biological activity by new amide compound of trimethoprim with some of its complexes |
| title_sort | evaluation the anticancer and biological activity by new amide compound of trimethoprim with some of its complexes |
| topic | drug trimethoprim amide structure hippuric acid anticancer |
| url | https://cjes.guilan.ac.ir/article_7323_ec2b0892f63ff84c279a68093026e5e1.pdf |
| work_keys_str_mv | AT alaaabdullahmajeed evaluationtheanticancerandbiologicalactivitybynewamidecompoundoftrimethoprimwithsomeofitscomplexes AT asmaamohammednoorikhaleel evaluationtheanticancerandbiologicalactivitybynewamidecompoundoftrimethoprimwithsomeofitscomplexes |