Astragaloside II pretreatment alleviates PM2.5-induced lung injury in mice via MAPK/Nrf2/GPX4 axis-mediated suppression of ferroptosis

Astragaloside II pretreatment alleviates PM2.5-induced lung injury in mice via MAPK/Nrf2/GPX4 axis-mediated suppression of ferroptosis

Exposure to fine particulate matter (PM2.5) induces inflammation and oxidative stress, contributing to respiratory diseases, including lung injury. Astragaloside II (AS II), a natural product derived from Astragali Radix (AR), demonstrates dual anti-inflammatory and antioxidant activities. This work...

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Bibliographic Details
Main Authors: Liyun Liu, Zherui Shen, Nan Jia, Qian Chen, Chen Chen, Yi Luo, Xuemei Dai, Sijing Zhao, Caixia Pei, Demei Huang, Yilan Wang, Tao Shen, Zhenxing Wang
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
PM2.5
Lung injury
Astragaloside II
MAPK/Nrf2/GPX4
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325009583
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