HDAC6 inhibitor-loaded brain-targeted nanocarrier-mediated neuroprotection in methamphetamine-driven Parkinson's disease

HDAC6 inhibitor-loaded brain-targeted nanocarrier-mediated neuroprotection in methamphetamine-driven Parkinson's disease

The dynamic equilibrium between acetylation and deacetylation is vital for cellular homeostasis. Parkinson's disease (PD), a neurodegenerative disorder marked by α-synuclein (α-syn) accumulation and dopaminergic neuron loss in the substantia nigra, is associated with a disruption of this balanc...

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Bibliographic Details
Main Authors: Khang-Yen Pham, Shristi Khanal, Ganesh Bohara, Nikesh Rimal, Sang-Hoon Song, Thoa Thi Kim Nguyen, In-Sun Hong, Jinkyung Cho, Jong-Sun Kang, Sooyeun Lee, Dong-Young Choi, Simmyung Yook
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Redox Biology
Subjects:
HDAC6 inhibitor
CAY10603
Parkinson's disease
Lactoferrin
PLGA nanoparticle
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172400435X
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