Measures of cellular oxidative damage following vitamin E supplementation in young patients with transfusion-dependent thalassemia: a double-blind randomized controlled trial

Measures of cellular oxidative damage following vitamin E supplementation in young patients with transfusion-dependent thalassemia: a double-blind randomized controlled trial

Abstract Background Patients with thalassemia acquire cellular oxidative damage mainly from the degradation of excessive uncoupled hemoglobin (Hb) chains and iron overload. The oxidative damage of red blood cells (RBCs) and platelets potentially results in the worsening of ineffective erythropoiesis...

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Main Authors: Nutthida Hemprachitchai, Rattanaporn Praneetponkang, Pakawan Wongwerawattanakoon, Chokdee Wongborisuth, Pawarit Innachai, Praguywan Kadegasem, Tanyanee Khlangtan, Thanaporn Sriwantana, Phanphen Phoonlapdacha, Oraporn Dumrongwongsiri, Ampaiwan Chuansumrit, Kovit Pattanapanyasat, Nongnuch Sirachainan, Nathawut Sibmooh, Pornthip Chaichompoo, Duantida Songdej
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Pediatrics
Subjects:
Vitamin E
Oxidative stress
Red cell pathology
Thalassemia
PS-bearing RBC
Food supplements
Online Access:https://doi.org/10.1186/s12887-025-05741-2
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