The Role of PPARs in Cancer
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. PPAR𝛼 is mainly expressed in the liver, where it activates fatty acid catabolism. PPAR𝛼 act...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/102737 |
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| _version_ | 1850106073164283904 |
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| author | Keisuke Tachibana Daisuke Yamasaki Kenji Ishimoto Takefumi Doi |
| author_facet | Keisuke Tachibana Daisuke Yamasaki Kenji Ishimoto Takefumi Doi |
| author_sort | Keisuke Tachibana |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors (PPARs) are ligand-activated
transcription factors that belong to the nuclear hormone receptor superfamily.
PPAR𝛼 is mainly
expressed in the liver, where it activates fatty acid catabolism. PPAR𝛼 activators have been used to treat dyslipidemia, causing a reduction in plasma triglyceride
and elevation of high-density lipoprotein cholesterol. PPAR𝛿 is expressed ubiquitously and is
implicated in fatty acid oxidation and keratinocyte differentiation. PPAR𝛿 activators
have been proposed for the treatment of metabolic disease. PPAR𝛾2 is expressed
exclusively in adipose tissue and plays a pivotal role in adipocyte differentiation.
PPAR𝛾 is involved in glucose metabolism through the improvement of insulin sensitivity
and represents a potential therapeutic target of type 2 diabetes. Thus PPARs are molecular
targets for the development of drugs treating metabolic syndrome. However, PPARs also play
a role in the regulation of cancer cell growth. Here, we review the function of PPARs in tumor
growth. |
| format | Article |
| id | doaj-art-31a61d79d22e41d5aa3898f7c5c51528 |
| institution | OA Journals |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-31a61d79d22e41d5aa3898f7c5c515282025-08-20T02:38:55ZengWileyPPAR Research1687-47571687-47652008-01-01200810.1155/2008/102737102737The Role of PPARs in CancerKeisuke Tachibana0Daisuke Yamasaki1Kenji Ishimoto2Takefumi Doi3Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, JapanGraduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, JapanGraduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, JapanGraduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, JapanPeroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. PPAR𝛼 is mainly expressed in the liver, where it activates fatty acid catabolism. PPAR𝛼 activators have been used to treat dyslipidemia, causing a reduction in plasma triglyceride and elevation of high-density lipoprotein cholesterol. PPAR𝛿 is expressed ubiquitously and is implicated in fatty acid oxidation and keratinocyte differentiation. PPAR𝛿 activators have been proposed for the treatment of metabolic disease. PPAR𝛾2 is expressed exclusively in adipose tissue and plays a pivotal role in adipocyte differentiation. PPAR𝛾 is involved in glucose metabolism through the improvement of insulin sensitivity and represents a potential therapeutic target of type 2 diabetes. Thus PPARs are molecular targets for the development of drugs treating metabolic syndrome. However, PPARs also play a role in the regulation of cancer cell growth. Here, we review the function of PPARs in tumor growth.http://dx.doi.org/10.1155/2008/102737 |
| spellingShingle | Keisuke Tachibana Daisuke Yamasaki Kenji Ishimoto Takefumi Doi The Role of PPARs in Cancer PPAR Research |
| title | The Role of PPARs in Cancer |
| title_full | The Role of PPARs in Cancer |
| title_fullStr | The Role of PPARs in Cancer |
| title_full_unstemmed | The Role of PPARs in Cancer |
| title_short | The Role of PPARs in Cancer |
| title_sort | role of ppars in cancer |
| url | http://dx.doi.org/10.1155/2008/102737 |
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