The Role of PPARs in Cancer
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. PPAR𝛼 is mainly expressed in the liver, where it activates fatty acid catabolism. PPAR𝛼 act...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2008-01-01
|
| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2008/102737 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Peroxisome proliferator-activated receptors (PPARs) are ligand-activated
transcription factors that belong to the nuclear hormone receptor superfamily.
PPAR𝛼 is mainly
expressed in the liver, where it activates fatty acid catabolism. PPAR𝛼 activators have been used to treat dyslipidemia, causing a reduction in plasma triglyceride
and elevation of high-density lipoprotein cholesterol. PPAR𝛿 is expressed ubiquitously and is
implicated in fatty acid oxidation and keratinocyte differentiation. PPAR𝛿 activators
have been proposed for the treatment of metabolic disease. PPAR𝛾2 is expressed
exclusively in adipose tissue and plays a pivotal role in adipocyte differentiation.
PPAR𝛾 is involved in glucose metabolism through the improvement of insulin sensitivity
and represents a potential therapeutic target of type 2 diabetes. Thus PPARs are molecular
targets for the development of drugs treating metabolic syndrome. However, PPARs also play
a role in the regulation of cancer cell growth. Here, we review the function of PPARs in tumor
growth. |
|---|---|
| ISSN: | 1687-4757 1687-4765 |