Effect of antisecretory treatment on gastrointestinal microbiota
Aim of review. To present the data on the effect of proton pump inhibitors to gastrointestinal microbiota. Summary. Proton pump inhibitors (PPI) - is a basic class of drugs for acid-related diseases treatment. The data proving gastrointestinal microbiota alteration at PPI administration were obtaine...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2018-08-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/220 |
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| author | D. Ye. Rumyantseva A. S. Trukhmanov A. V. Kudryavtseva V. T. Ivashkin |
| author_facet | D. Ye. Rumyantseva A. S. Trukhmanov A. V. Kudryavtseva V. T. Ivashkin |
| author_sort | D. Ye. Rumyantseva |
| collection | DOAJ |
| description | Aim of review. To present the data on the effect of proton pump inhibitors to gastrointestinal microbiota. Summary. Proton pump inhibitors (PPI) - is a basic class of drugs for acid-related diseases treatment. The data proving gastrointestinal microbiota alteration at PPI administration were obtained. Possible mechanism may include the direct action on bacterial H+/ K+-ATPase, as well as indirect action on the environment pH. Increase of Lachnospiraceae family bacteria quantity in esophagus after PPI treatment and unclassified Clostridial families alone with reduction of Methylobacteriaceae family were observed. Decrease of Moraxellaceae, Flavobacteriaceae, Comamonadaceae, Methylobacteriaceae family bacteria and increase of Erysipelotrichaceae family and unclassified Clostridiales order families was noted in the stomach. Long-term PPI intake can result in development of small-intestinal bacterial overgrowth syndrome, and also can be associated to development of Clostridium difficile-associated disease. Conclusion. The data of few available studies demonstrate microbiota changes throughout gastrointestinal tract at PPI intake. However these results are inconsistent and provide no definite answer whether this changes are beneficial or harmful that requires further studies. |
| format | Article |
| id | doaj-art-31a30e87e4f34d07a37bcb9e1b594815 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-31a30e87e4f34d07a37bcb9e1b5948152025-02-10T16:14:28ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-08-01281788810.22416/1382-4376-2018-28-1-78-88220Effect of antisecretory treatment on gastrointestinal microbiotaD. Ye. Rumyantseva0A. S. Trukhmanov1A. V. Kudryavtseva2V. T. Ivashkin3Federal State educational Autonomous institution of higher education «Sechenov First Moscow state medical university»Federal State educational Autonomous institution of higher education «Sechenov First Moscow state medical university»Engelgardt institute of molecular biology; National medical research radiological centerFederal State educational Autonomous institution of higher education «Sechenov First Moscow state medical university»Aim of review. To present the data on the effect of proton pump inhibitors to gastrointestinal microbiota. Summary. Proton pump inhibitors (PPI) - is a basic class of drugs for acid-related diseases treatment. The data proving gastrointestinal microbiota alteration at PPI administration were obtained. Possible mechanism may include the direct action on bacterial H+/ K+-ATPase, as well as indirect action on the environment pH. Increase of Lachnospiraceae family bacteria quantity in esophagus after PPI treatment and unclassified Clostridial families alone with reduction of Methylobacteriaceae family were observed. Decrease of Moraxellaceae, Flavobacteriaceae, Comamonadaceae, Methylobacteriaceae family bacteria and increase of Erysipelotrichaceae family and unclassified Clostridiales order families was noted in the stomach. Long-term PPI intake can result in development of small-intestinal bacterial overgrowth syndrome, and also can be associated to development of Clostridium difficile-associated disease. Conclusion. The data of few available studies demonstrate microbiota changes throughout gastrointestinal tract at PPI intake. However these results are inconsistent and provide no definite answer whether this changes are beneficial or harmful that requires further studies.https://www.gastro-j.ru/jour/article/view/220микробиотаингибиторы протонной помпырабепразол |
| spellingShingle | D. Ye. Rumyantseva A. S. Trukhmanov A. V. Kudryavtseva V. T. Ivashkin Effect of antisecretory treatment on gastrointestinal microbiota Российский журнал гастроэнтерологии, гепатологии, колопроктологии микробиота ингибиторы протонной помпы рабепразол |
| title | Effect of antisecretory treatment on gastrointestinal microbiota |
| title_full | Effect of antisecretory treatment on gastrointestinal microbiota |
| title_fullStr | Effect of antisecretory treatment on gastrointestinal microbiota |
| title_full_unstemmed | Effect of antisecretory treatment on gastrointestinal microbiota |
| title_short | Effect of antisecretory treatment on gastrointestinal microbiota |
| title_sort | effect of antisecretory treatment on gastrointestinal microbiota |
| topic | микробиота ингибиторы протонной помпы рабепразол |
| url | https://www.gastro-j.ru/jour/article/view/220 |
| work_keys_str_mv | AT dyerumyantseva effectofantisecretorytreatmentongastrointestinalmicrobiota AT astrukhmanov effectofantisecretorytreatmentongastrointestinalmicrobiota AT avkudryavtseva effectofantisecretorytreatmentongastrointestinalmicrobiota AT vtivashkin effectofantisecretorytreatmentongastrointestinalmicrobiota |