Household triclosan and triclocarban effects on the infant and maternal microbiome
Abstract In 2016, the US Food and Drug Administration banned the use of specific microbicides in some household and personal wash products due to concerns that these chemicals might induce antibiotic resistance or disrupt human microbial communities. Triclosan and triclocarban (referred to as TCs) a...
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| Format: | Article |
| Language: | English |
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Springer Nature
2017-10-01
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| Series: | EMBO Molecular Medicine |
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| Online Access: | https://doi.org/10.15252/emmm.201707882 |
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| author | Jessica V Ribado Catherine Ley Thomas D Haggerty Ekaterina Tkachenko Ami S Bhatt Julie Parsonnet |
| author_facet | Jessica V Ribado Catherine Ley Thomas D Haggerty Ekaterina Tkachenko Ami S Bhatt Julie Parsonnet |
| author_sort | Jessica V Ribado |
| collection | DOAJ |
| description | Abstract In 2016, the US Food and Drug Administration banned the use of specific microbicides in some household and personal wash products due to concerns that these chemicals might induce antibiotic resistance or disrupt human microbial communities. Triclosan and triclocarban (referred to as TCs) are the most common antimicrobials in household and personal care products, but the extent to which TC exposure perturbs microbial communities in humans, particularly during infant development, was unknown. We conducted a randomized intervention of TC‐containing household and personal care products during the first year following birth to characterize whether TC exposure from wash products perturbs microbial communities in mothers and their infants. Longitudinal survey of the gut microbiota using 16S ribosomal RNA amplicon sequencing showed that TC exposure from wash products did not induce global reconstruction or loss of microbial diversity of either infant or maternal gut microbiotas. Broadly antibiotic‐resistant species from the phylum Proteobacteria, however, were enriched in stool samples from mothers in TC households after the introduction of triclosan‐containing toothpaste. When compared by urinary triclosan level, agnostic to treatment arm, infants with higher triclosan levels also showed an enrichment of Proteobacteria species. Despite the minimal effects of TC exposure from wash products on the gut microbial community of infants and adults, detected taxonomic differences highlight the need for consumer safety testing of antimicrobial self‐care products on the human microbiome and on antibiotic resistance. |
| format | Article |
| id | doaj-art-31a2b2f48d6248119d734305ff82ece4 |
| institution | Kabale University |
| issn | 1757-4676 1757-4684 |
| language | English |
| publishDate | 2017-10-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj-art-31a2b2f48d6248119d734305ff82ece42025-08-20T04:03:03ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842017-10-019121732174110.15252/emmm.201707882Household triclosan and triclocarban effects on the infant and maternal microbiomeJessica V Ribado0Catherine Ley1Thomas D Haggerty2Ekaterina Tkachenko3Ami S Bhatt4Julie Parsonnet5Department of Genetics, Stanford UniversityDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford UniversityDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford UniversityDivision of Hematology, Department of Medicine, Stanford UniversityDepartment of Genetics, Stanford UniversityDivision of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford UniversityAbstract In 2016, the US Food and Drug Administration banned the use of specific microbicides in some household and personal wash products due to concerns that these chemicals might induce antibiotic resistance or disrupt human microbial communities. Triclosan and triclocarban (referred to as TCs) are the most common antimicrobials in household and personal care products, but the extent to which TC exposure perturbs microbial communities in humans, particularly during infant development, was unknown. We conducted a randomized intervention of TC‐containing household and personal care products during the first year following birth to characterize whether TC exposure from wash products perturbs microbial communities in mothers and their infants. Longitudinal survey of the gut microbiota using 16S ribosomal RNA amplicon sequencing showed that TC exposure from wash products did not induce global reconstruction or loss of microbial diversity of either infant or maternal gut microbiotas. Broadly antibiotic‐resistant species from the phylum Proteobacteria, however, were enriched in stool samples from mothers in TC households after the introduction of triclosan‐containing toothpaste. When compared by urinary triclosan level, agnostic to treatment arm, infants with higher triclosan levels also showed an enrichment of Proteobacteria species. Despite the minimal effects of TC exposure from wash products on the gut microbial community of infants and adults, detected taxonomic differences highlight the need for consumer safety testing of antimicrobial self‐care products on the human microbiome and on antibiotic resistance.https://doi.org/10.15252/emmm.201707882antibioticmicrobiomeresistancetriclosan |
| spellingShingle | Jessica V Ribado Catherine Ley Thomas D Haggerty Ekaterina Tkachenko Ami S Bhatt Julie Parsonnet Household triclosan and triclocarban effects on the infant and maternal microbiome EMBO Molecular Medicine antibiotic microbiome resistance triclosan |
| title | Household triclosan and triclocarban effects on the infant and maternal microbiome |
| title_full | Household triclosan and triclocarban effects on the infant and maternal microbiome |
| title_fullStr | Household triclosan and triclocarban effects on the infant and maternal microbiome |
| title_full_unstemmed | Household triclosan and triclocarban effects on the infant and maternal microbiome |
| title_short | Household triclosan and triclocarban effects on the infant and maternal microbiome |
| title_sort | household triclosan and triclocarban effects on the infant and maternal microbiome |
| topic | antibiotic microbiome resistance triclosan |
| url | https://doi.org/10.15252/emmm.201707882 |
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