STK3 is a transcriptional target of YAP1 and a hub component in the crosstalk between Hippo and Wnt signaling pathways during gastric carcinogenesis

STK3 is a transcriptional target of YAP1 and a hub component in the crosstalk between Hippo and Wnt signaling pathways during gastric carcinogenesis

Abstract Background Serine/threonine kinase 3 (STK3) is recognized as a key regulator in Hippo pathway and a tumor-suppressing gene in various cancer types. However, its non-canonical role has been gradually revealed in cancer development. Methods Our objective is to elucidate the upregulation patte...

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Main Authors: Fuda Xie, Yang Lyu, Bonan Chen, Hoi Wing Leung, Peiyao Yu, Tiejun Feng, Canbin Fang, Alvin H.K. Cheung, Bin Zhou, Jianhui Jiang, Ge Zhang, Dazhi Xu, Liang Li, Chen Jiang, Jianwu Chen, Zhaocai Zhou, Liwei An, Bing Huang, Kangmin Zhuang, Xiaobei Luo, Kam Tong Leung, Ching Hei To, Brigette BY Ma, Chi Chun Wong, William KK Wu, Jun Yu, Ka Fai To, Wei Kang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Molecular Cancer
Subjects:
STK3
YAP1
Wnt signaling
Gastric cancer
Online Access:https://doi.org/10.1186/s12943-025-02391-x
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