Prevalence of Respiratory Syncytial Virus Infection in Hospitalized COPD Patients in Spain Between 2018–2022
Background: Respiratory syncytial virus (RSV) infection is a common cause of hospital admission. The association between chronic obstructive pulmonary disease (COPD) exacerbation and RSV infection is not well studied. Objective: To analyze the hospitalizations of patients with COPD and RSV infection...
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MDPI AG
2025-01-01
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| author | Rosa María Gómez-García Javier De-Miguel-Díez Ana López-de-Andrés Valentín Hernández-Barrera Ana Jimenez-Sierra Natividad Cuadrado-Corrales José J. Zamorano-León David Carabantes-Alarcón Andrés Bodas-Pinedo Rodrigo Jiménez-García |
| author_facet | Rosa María Gómez-García Javier De-Miguel-Díez Ana López-de-Andrés Valentín Hernández-Barrera Ana Jimenez-Sierra Natividad Cuadrado-Corrales José J. Zamorano-León David Carabantes-Alarcón Andrés Bodas-Pinedo Rodrigo Jiménez-García |
| author_sort | Rosa María Gómez-García |
| collection | DOAJ |
| description | Background: Respiratory syncytial virus (RSV) infection is a common cause of hospital admission. The association between chronic obstructive pulmonary disease (COPD) exacerbation and RSV infection is not well studied. Objective: To analyze the hospitalizations of patients with COPD and RSV infection in Spain between 2018 and 2022. Methods: The data used were obtained from the Spanish Hospital Discharge Database. We selected subjects aged ≥40 years diagnosed with COPD, admitted to the hospital from 1 January 2018 to 31 December 2022. The COPD population that met the selection criteria was subdivided based on the presence of an ICD-10 code for RSV infection. To obtain comparable populations, for each subject with COPD and RSV infection, a subject without an RSV code was selected, with the COPD code in the same diagnostic position (1 to 20), as well as the same year of admission, sex, and age. Results: Among subjects aged ≥40 years, 1,429,288 were identified as having COPD, of whom 5673 also had RSV infection. The number of hospitalizations with COPD and RSV infection increased during the study period. The proportion of RSV infection among patients admitted for COPD increased significantly over time, from 0.32% in 2018 to 0.65% in 2022, <i>p</i> < 0.001. In-hospital mortality (IHM) increased over time, but the differences were not significant (6.23% in 2018 vs. 6.79% in 2022). Patients with COPD and RSV infection had, compared with those without RSV infection, a higher use of mechanical ventilation, both invasive (3.44% vs. 1.34%, <i>p</i> < 0.001) and noninvasive (8.09% vs. 4.51%, <i>p</i> < 0.001) and a higher proportion of intensive care unit (ICU) admission (7.21% vs. 3.9%, <i>p</i> < 0.001). After multivariate adjustment, a significant increase in IHM was found from 2018 to 2022 in subjects with and without RSV infection. The presence of RSV infection was associated with a higher mortality (OR 1.22; 95% CI 1.01–1.46). Conclusions: The proportion of RSV infection among patients admitted for COPD increased significantly over time. Patients with COPD and RSV infection had, compared with those without RSV infection, a higher severity, a higher use of mechanical ventilation, and a higher proportion of ICU admission. The presence of RSV infection was associated with IHM. These results can help to identify patients at higher risk and make decisions to avoid the increased risk of hospitalization and mortality in this population. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-319de1e148634098a5a882be26eb00ef2025-01-24T13:29:17ZengMDPI AGDiseases2079-97212025-01-011312310.3390/diseases13010023Prevalence of Respiratory Syncytial Virus Infection in Hospitalized COPD Patients in Spain Between 2018–2022Rosa María Gómez-García0Javier De-Miguel-Díez1Ana López-de-Andrés2Valentín Hernández-Barrera3Ana Jimenez-Sierra4Natividad Cuadrado-Corrales5José J. Zamorano-León6David Carabantes-Alarcón7Andrés Bodas-Pinedo8Rodrigo Jiménez-García9Respiratory Care Department, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), 28007 Madrid, SpainRespiratory Care Department, Hospital General Universitario Gregorio Marañón, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), 28007 Madrid, SpainDepartment of Public Health & Maternal and Child Health, Faculty of Pharmacy, Universidad Complutense de Madrid, 28040 Madrid, SpainPreventive Medicine and Public Health Teaching and Research Unit, Health Sciences Faculty, Rey Juan Carlos University, 28922 Alcorcón, SpainFaculty of Medicine, Universidad San Pablo Ceu, 28668 Madrid, SpainDepartment of Public Health & Maternal and Child Health, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartment of Public Health & Maternal and Child Health, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartment of Public Health & Maternal and Child Health, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartment of Public Health & Maternal and Child Health, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartment of Public Health & Maternal and Child Health, Faculty of Medicine, Universidad Complutense de Madrid, 28040 Madrid, SpainBackground: Respiratory syncytial virus (RSV) infection is a common cause of hospital admission. The association between chronic obstructive pulmonary disease (COPD) exacerbation and RSV infection is not well studied. Objective: To analyze the hospitalizations of patients with COPD and RSV infection in Spain between 2018 and 2022. Methods: The data used were obtained from the Spanish Hospital Discharge Database. We selected subjects aged ≥40 years diagnosed with COPD, admitted to the hospital from 1 January 2018 to 31 December 2022. The COPD population that met the selection criteria was subdivided based on the presence of an ICD-10 code for RSV infection. To obtain comparable populations, for each subject with COPD and RSV infection, a subject without an RSV code was selected, with the COPD code in the same diagnostic position (1 to 20), as well as the same year of admission, sex, and age. Results: Among subjects aged ≥40 years, 1,429,288 were identified as having COPD, of whom 5673 also had RSV infection. The number of hospitalizations with COPD and RSV infection increased during the study period. The proportion of RSV infection among patients admitted for COPD increased significantly over time, from 0.32% in 2018 to 0.65% in 2022, <i>p</i> < 0.001. In-hospital mortality (IHM) increased over time, but the differences were not significant (6.23% in 2018 vs. 6.79% in 2022). Patients with COPD and RSV infection had, compared with those without RSV infection, a higher use of mechanical ventilation, both invasive (3.44% vs. 1.34%, <i>p</i> < 0.001) and noninvasive (8.09% vs. 4.51%, <i>p</i> < 0.001) and a higher proportion of intensive care unit (ICU) admission (7.21% vs. 3.9%, <i>p</i> < 0.001). After multivariate adjustment, a significant increase in IHM was found from 2018 to 2022 in subjects with and without RSV infection. The presence of RSV infection was associated with a higher mortality (OR 1.22; 95% CI 1.01–1.46). Conclusions: The proportion of RSV infection among patients admitted for COPD increased significantly over time. Patients with COPD and RSV infection had, compared with those without RSV infection, a higher severity, a higher use of mechanical ventilation, and a higher proportion of ICU admission. The presence of RSV infection was associated with IHM. These results can help to identify patients at higher risk and make decisions to avoid the increased risk of hospitalization and mortality in this population.https://www.mdpi.com/2079-9721/13/1/23COPDrespiratory syncytial virushospitalizationsmortalitySpain |
| spellingShingle | Rosa María Gómez-García Javier De-Miguel-Díez Ana López-de-Andrés Valentín Hernández-Barrera Ana Jimenez-Sierra Natividad Cuadrado-Corrales José J. Zamorano-León David Carabantes-Alarcón Andrés Bodas-Pinedo Rodrigo Jiménez-García Prevalence of Respiratory Syncytial Virus Infection in Hospitalized COPD Patients in Spain Between 2018–2022 Diseases COPD respiratory syncytial virus hospitalizations mortality Spain |
| title | Prevalence of Respiratory Syncytial Virus Infection in Hospitalized COPD Patients in Spain Between 2018–2022 |
| title_full | Prevalence of Respiratory Syncytial Virus Infection in Hospitalized COPD Patients in Spain Between 2018–2022 |
| title_fullStr | Prevalence of Respiratory Syncytial Virus Infection in Hospitalized COPD Patients in Spain Between 2018–2022 |
| title_full_unstemmed | Prevalence of Respiratory Syncytial Virus Infection in Hospitalized COPD Patients in Spain Between 2018–2022 |
| title_short | Prevalence of Respiratory Syncytial Virus Infection in Hospitalized COPD Patients in Spain Between 2018–2022 |
| title_sort | prevalence of respiratory syncytial virus infection in hospitalized copd patients in spain between 2018 2022 |
| topic | COPD respiratory syncytial virus hospitalizations mortality Spain |
| url | https://www.mdpi.com/2079-9721/13/1/23 |
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