The relationship between abnormal glucose metabolism and chronic pain
Abstract Chronic pain has a serious impact on the quality of patients' life. Currently, the mechanism of chronic pain has not been fully studied, and the treatments are often ineffective. Abnormal glucose metabolism plays an important role in the occurrence and development of chronic pain. It h...
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| Format: | Article |
| Language: | English |
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BMC
2025-06-01
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| Series: | Cell & Bioscience |
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| Online Access: | https://doi.org/10.1186/s13578-025-01430-w |
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| author | Lulin Ma Yaoling Wang Yi Zhao Meng Sun Tao Zhu Cheng Zhou |
| author_facet | Lulin Ma Yaoling Wang Yi Zhao Meng Sun Tao Zhu Cheng Zhou |
| author_sort | Lulin Ma |
| collection | DOAJ |
| description | Abstract Chronic pain has a serious impact on the quality of patients' life. Currently, the mechanism of chronic pain has not been fully studied, and the treatments are often ineffective. Abnormal glucose metabolism plays an important role in the occurrence and development of chronic pain. It has been found that the abnormal glucose metabolism in anterior cingulate cortex (ACC), visual cortex, occipital cortex, brain stem, hippocampus, orbitofrontal cortex (OFC), thalamus and insula is involved in the primary headache (migraine); In addition, the abnormal glucose metabolism in the medial prefrontal cortex (mPFC), ACC, hippocampus, thalamus, primary somatosensory cortices (SI), OFC and cerebellum is involved in the neuropathic pain (NP); the abnormal glucose metabolism in the thalamus and brain stem is also involved in other types of chronic pain. Pain relieving therapies, such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), electroacupuncture (EA) and acupuncture treatment can alleviate chronic pain by reversing abnormal glucose metabolism in some of the above brain regions. In conclusion, although further research is needed, the abnormal glucose metabolism and related treatment may be an important direction for the treatment of chronic pain, and relevant mechanisms still need to be further explored. |
| format | Article |
| id | doaj-art-319cbc4947e94e109dc1b896879bafa4 |
| institution | Kabale University |
| issn | 2045-3701 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell & Bioscience |
| spelling | doaj-art-319cbc4947e94e109dc1b896879bafa42025-08-20T03:47:16ZengBMCCell & Bioscience2045-37012025-06-0115111310.1186/s13578-025-01430-wThe relationship between abnormal glucose metabolism and chronic painLulin Ma0Yaoling Wang1Yi Zhao2Meng Sun3Tao Zhu4Cheng Zhou5Department of Anesthesiology, West China Hospital of Sichuan UniversityCenter of Gerontology and Geriatrics, West China Hospital, National Clinical Research Center for Geriatrics, Sichuan UniversityDepartment of Anesthesiology, West China Hospital of Sichuan UniversityDepartment of Anesthesiology, West China Hospital of Sichuan UniversityDepartment of Anesthesiology, West China Hospital of Sichuan UniversityResearch Institution of Anesthesiology, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan UniversityAbstract Chronic pain has a serious impact on the quality of patients' life. Currently, the mechanism of chronic pain has not been fully studied, and the treatments are often ineffective. Abnormal glucose metabolism plays an important role in the occurrence and development of chronic pain. It has been found that the abnormal glucose metabolism in anterior cingulate cortex (ACC), visual cortex, occipital cortex, brain stem, hippocampus, orbitofrontal cortex (OFC), thalamus and insula is involved in the primary headache (migraine); In addition, the abnormal glucose metabolism in the medial prefrontal cortex (mPFC), ACC, hippocampus, thalamus, primary somatosensory cortices (SI), OFC and cerebellum is involved in the neuropathic pain (NP); the abnormal glucose metabolism in the thalamus and brain stem is also involved in other types of chronic pain. Pain relieving therapies, such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), electroacupuncture (EA) and acupuncture treatment can alleviate chronic pain by reversing abnormal glucose metabolism in some of the above brain regions. In conclusion, although further research is needed, the abnormal glucose metabolism and related treatment may be an important direction for the treatment of chronic pain, and relevant mechanisms still need to be further explored.https://doi.org/10.1186/s13578-025-01430-wChronic painMigraineNeuropathic painAbnormal glucose metabolismBrainTMS |
| spellingShingle | Lulin Ma Yaoling Wang Yi Zhao Meng Sun Tao Zhu Cheng Zhou The relationship between abnormal glucose metabolism and chronic pain Cell & Bioscience Chronic pain Migraine Neuropathic pain Abnormal glucose metabolism Brain TMS |
| title | The relationship between abnormal glucose metabolism and chronic pain |
| title_full | The relationship between abnormal glucose metabolism and chronic pain |
| title_fullStr | The relationship between abnormal glucose metabolism and chronic pain |
| title_full_unstemmed | The relationship between abnormal glucose metabolism and chronic pain |
| title_short | The relationship between abnormal glucose metabolism and chronic pain |
| title_sort | relationship between abnormal glucose metabolism and chronic pain |
| topic | Chronic pain Migraine Neuropathic pain Abnormal glucose metabolism Brain TMS |
| url | https://doi.org/10.1186/s13578-025-01430-w |
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