CAF-derived exosomal miR-196b-5p after androgen deprivation therapy promotes epithelial-mesenchymal transition in prostate cancer cells through HOXC8/NF-κB signaling pathway

CAF-derived exosomal miR-196b-5p after androgen deprivation therapy promotes epithelial-mesenchymal transition in prostate cancer cells through HOXC8/NF-κB signaling pathway

Abstract Background Cancer-associated fibroblasts (CAFs) have been reported to play a significant role in the development and metastasis of various tumors; however, research on their role in promoting prostate cancer (PCa) metastasis under castration conditions remains unclear. Methods In this study...

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Bibliographic Details
Main Authors: Xiaodong Song, Tiewen Li, Wenhao Zhou, Chengling Feng, Zeng Zhou, Yuanming Chen, Deng Li, Lei Chen, Jing Zhao, Yu Zhang, Bangmin Han
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Biology Direct
Subjects:
Prostate cancer
Exosome
Cancer-associated fibroblasts
miR-196b-5p
HOXC8
NF-κB
Online Access:https://doi.org/10.1186/s13062-025-00667-2
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