In vivo armed macrophages curb liver metastasis through tumor-reactive T-cell rejuvenation

In vivo armed macrophages curb liver metastasis through tumor-reactive T-cell rejuvenation

Abstract Despite recent progress in cancer treatment, liver metastases persist as an unmet clinical need. Here, we show that arming liver and tumor-associated macrophages in vivo to co-express tumor antigens (TAs), IFNα, and IL-12 unleashes robust anti-tumor immune responses, leading to the regressi...

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Bibliographic Details
Main Authors: Marco Notaro, Maristella Borghetti, Chiara Bresesti, Giovanna Giacca, Thomas Kerzel, Carl Mirko Mercado, Stefano Beretta, Marco Monti, Ivan Merelli, Silvia Iaia, Marco Genua, Andrea Annoni, Tamara Canu, Patrizia Cristofori, Sara Degl’Innocenti, Francesca Sanvito, Paola Maria Vittoria Rancoita, Renato Ostuni, Silvia Gregori, Luigi Naldini, Mario Leonardo Squadrito
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58369-2
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