Differentiation between glioblastoma and solitary brain metastases using perfusion and amide proton transfer weighted MRI
ObjectivesEarly diagnostic separation between glioblastoma (GBM) and solitary metastases (MET) is important for patient management but remains challenging when based on imaging only. The objective of this study was to assess whether amide proton transfer weighted (APTw) MRI alone or combined with dy...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1533799/full |
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| author | Malte Knutsson Tim Salomonsson Faris Durmo Emelie Ryd Johansson Anina Seidemo Jimmy Lätt Anna Rydelius Sara Kinhult Elisabet Englund Johan Bengzon Peter C. M. van Zijl Peter C. M. van Zijl Linda Knutsson Linda Knutsson Linda Knutsson Pia C. Sundgren Pia C. Sundgren Pia C. Sundgren |
| author_facet | Malte Knutsson Tim Salomonsson Faris Durmo Emelie Ryd Johansson Anina Seidemo Jimmy Lätt Anna Rydelius Sara Kinhult Elisabet Englund Johan Bengzon Peter C. M. van Zijl Peter C. M. van Zijl Linda Knutsson Linda Knutsson Linda Knutsson Pia C. Sundgren Pia C. Sundgren Pia C. Sundgren |
| author_sort | Malte Knutsson |
| collection | DOAJ |
| description | ObjectivesEarly diagnostic separation between glioblastoma (GBM) and solitary metastases (MET) is important for patient management but remains challenging when based on imaging only. The objective of this study was to assess whether amide proton transfer weighted (APTw) MRI alone or combined with dynamic susceptibility contrast (DSC) MRI parameters, including cerebral blood volume (CBV), cerebral blood flow (CBF), and leakage parameter (K2) measurements, can differentiate GBM from MET.MethodsAPTw MRI and DSC-MRI were performed on 18 patients diagnosed with GBM (N = 10) or MET (N = 8). Quantitative parameter maps were calculated, and regions-of-interest (ROIs) were placed in whole tumor, contrast-enhanced tumor (ET), edema, necrosis and normal-appearing white matter (NAWM). The mean and max of the APTw signal, CBF, leakage-corrected CBV and K2 were obtained from each ROI. Except for K2, all were normalized to NAWM (nAPTwmean/max, nCBFmean/max, ncCBVmean/max,). Receiver Operating Characteristic (ROC) curves and area-under-the-curve (AUC) were assessed for different parameter combinations. Statistical analyses were performed using Mann–Whitney U test.ResultsWhen comparing GBM to MET, nAPTmax, nCBFmax, ncCBVmax and ncCBVmean were significantly increased (p < 0.05) in ET with AUC being 0.81, 0.83, 0.85, and 0.83, respectively. Combinations of nAPTwmax + ncCBVmax, nAPTwmean + ncCBVmean, nAPTwmax + nCBFmax, nAPTwmax + K2max and nAPTwmax + ncCBVmax + K2max in ET showed significant prediction in differentiating GBM and MET (AUC = 0.92, 0.82, 0.92, 0.85, and 0.92 respectively).ConclusionWhen assessed in Gd-enhanced tumor areas, nAPTw MRI signal intensity alone or combined with DSC-MRI parameters, was an excellent predictor for differentiating GBM and MET. However, the small cohort warrants future studies. |
| format | Article |
| id | doaj-art-3192087275544a058f11984c2ed07643 |
| institution | Kabale University |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj-art-3192087275544a058f11984c2ed076432025-02-05T07:32:39ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-02-011910.3389/fnins.2025.15337991533799Differentiation between glioblastoma and solitary brain metastases using perfusion and amide proton transfer weighted MRIMalte Knutsson0Tim Salomonsson1Faris Durmo2Emelie Ryd Johansson3Anina Seidemo4Jimmy Lätt5Anna Rydelius6Sara Kinhult7Elisabet Englund8Johan Bengzon9Peter C. M. van Zijl10Peter C. M. van Zijl11Linda Knutsson12Linda Knutsson13Linda Knutsson14Pia C. Sundgren15Pia C. Sundgren16Pia C. Sundgren17Department of Clinical Sciences, Division of Radiology, Lund University, Lund, SwedenDepartment of Clinical Sciences, Division of Radiology, Lund University, Lund, SwedenDepartment of Clinical Sciences, Division of Radiology, Lund University, Lund, SwedenDepartment of Clinical Sciences, Division of Radiology, Lund University, Lund, SwedenDepartment of Clinical Sciences, Division of Radiology, Lund University, Lund, SwedenDepartment of Medical Imaging and Physiology, Skåne University Hospital, Lund, SwedenDepartment of Clinical Sciences, Division of Neurology, Lund University, Lund, SwedenDepartment of Clinical Sciences, Division of Oncology, Lund University, Lund, SwedenDepartment of Clinical Sciences, Division of Pathology, Lund University, Lund, SwedenDepartment of Clinical Sciences, Division of Neurosurgery, Lund University, Lund, SwedenF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United StatesDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesF.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United StatesDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States0Department of Medical Radiation Physics, Lund University, Lund, SwedenDepartment of Clinical Sciences, Division of Radiology, Lund University, Lund, SwedenDepartment of Medical Imaging and Physiology, Skåne University Hospital, Lund, Sweden1LBIC, Lund University Bioimaging Center, Lund University, Lund, SwedenObjectivesEarly diagnostic separation between glioblastoma (GBM) and solitary metastases (MET) is important for patient management but remains challenging when based on imaging only. The objective of this study was to assess whether amide proton transfer weighted (APTw) MRI alone or combined with dynamic susceptibility contrast (DSC) MRI parameters, including cerebral blood volume (CBV), cerebral blood flow (CBF), and leakage parameter (K2) measurements, can differentiate GBM from MET.MethodsAPTw MRI and DSC-MRI were performed on 18 patients diagnosed with GBM (N = 10) or MET (N = 8). Quantitative parameter maps were calculated, and regions-of-interest (ROIs) were placed in whole tumor, contrast-enhanced tumor (ET), edema, necrosis and normal-appearing white matter (NAWM). The mean and max of the APTw signal, CBF, leakage-corrected CBV and K2 were obtained from each ROI. Except for K2, all were normalized to NAWM (nAPTwmean/max, nCBFmean/max, ncCBVmean/max,). Receiver Operating Characteristic (ROC) curves and area-under-the-curve (AUC) were assessed for different parameter combinations. Statistical analyses were performed using Mann–Whitney U test.ResultsWhen comparing GBM to MET, nAPTmax, nCBFmax, ncCBVmax and ncCBVmean were significantly increased (p < 0.05) in ET with AUC being 0.81, 0.83, 0.85, and 0.83, respectively. Combinations of nAPTwmax + ncCBVmax, nAPTwmean + ncCBVmean, nAPTwmax + nCBFmax, nAPTwmax + K2max and nAPTwmax + ncCBVmax + K2max in ET showed significant prediction in differentiating GBM and MET (AUC = 0.92, 0.82, 0.92, 0.85, and 0.92 respectively).ConclusionWhen assessed in Gd-enhanced tumor areas, nAPTw MRI signal intensity alone or combined with DSC-MRI parameters, was an excellent predictor for differentiating GBM and MET. However, the small cohort warrants future studies.https://www.frontiersin.org/articles/10.3389/fnins.2025.1533799/fullgliomametastasesCESTamide proton transfer-weighted imagingdynamic susceptibility contrast MRI |
| spellingShingle | Malte Knutsson Tim Salomonsson Faris Durmo Emelie Ryd Johansson Anina Seidemo Jimmy Lätt Anna Rydelius Sara Kinhult Elisabet Englund Johan Bengzon Peter C. M. van Zijl Peter C. M. van Zijl Linda Knutsson Linda Knutsson Linda Knutsson Pia C. Sundgren Pia C. Sundgren Pia C. Sundgren Differentiation between glioblastoma and solitary brain metastases using perfusion and amide proton transfer weighted MRI Frontiers in Neuroscience glioma metastases CEST amide proton transfer-weighted imaging dynamic susceptibility contrast MRI |
| title | Differentiation between glioblastoma and solitary brain metastases using perfusion and amide proton transfer weighted MRI |
| title_full | Differentiation between glioblastoma and solitary brain metastases using perfusion and amide proton transfer weighted MRI |
| title_fullStr | Differentiation between glioblastoma and solitary brain metastases using perfusion and amide proton transfer weighted MRI |
| title_full_unstemmed | Differentiation between glioblastoma and solitary brain metastases using perfusion and amide proton transfer weighted MRI |
| title_short | Differentiation between glioblastoma and solitary brain metastases using perfusion and amide proton transfer weighted MRI |
| title_sort | differentiation between glioblastoma and solitary brain metastases using perfusion and amide proton transfer weighted mri |
| topic | glioma metastases CEST amide proton transfer-weighted imaging dynamic susceptibility contrast MRI |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1533799/full |
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