Green Synthesis of Silver Nanoparticles Using Extracts of Ehretia cymosa and Evaluation of Its Antibacterial Activity in Cream and Ointment Drug Delivery Systems
Objectives. The use of antibacterial drugs for the treatment of infections has been on for several decades but not without some challenges such as resistance. Research on natural products is on-going to mitigate this challenge. The aim of this study was to synthesize silver nanoparticles (SNPs) with...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Journal of Nanotechnology |
| Online Access: | http://dx.doi.org/10.1155/2023/2808015 |
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| author | Olutayo Ademola Adeleye Olatunji Kayode Aremu Haroon Iqbal Musiliu Oluseun Adedokun Oluyemisi Adebowale Bamiro Olufemi Lionel Okunye Mbang N. Femi-Oyewo Kehinde Oluseun Sodeinde Zwanden S. Yahaya Adepero Olubukola Awolesi |
| author_facet | Olutayo Ademola Adeleye Olatunji Kayode Aremu Haroon Iqbal Musiliu Oluseun Adedokun Oluyemisi Adebowale Bamiro Olufemi Lionel Okunye Mbang N. Femi-Oyewo Kehinde Oluseun Sodeinde Zwanden S. Yahaya Adepero Olubukola Awolesi |
| author_sort | Olutayo Ademola Adeleye |
| collection | DOAJ |
| description | Objectives. The use of antibacterial drugs for the treatment of infections has been on for several decades but not without some challenges such as resistance. Research on natural products is on-going to mitigate this challenge. The aim of this study was to synthesize silver nanoparticles (SNPs) with aqueous and methanol extract of Ehretia cymosa leaf and to explore its antibacterial potentials in semisolid dosage delivery system as topical antibacterial cream and ointment. Methods. E. cymosa leaf was extracted by macerating in distilled water and methanol. The extracts were used to synthesize SNPs. SNPs were characterized and confirmed by visual observation, UV-visible spectroscopy, FTIR, atomic absorption spectroscopy, scanning electron microscopy, and energy dispersive X-ray spectroscopy. SNPs were used to formulate cream and ointment, and the antibacterial activity of the formulations was evaluated against Staphylococcus aureus and Escherichia coli. Results. Absorption band was observed at 450 nm for aqueous extract SNPs and 420 nm for methanol extract SNPs due to surface plasmon resonance. SNPs were agglomerated with the irregular size of 55 nm and 90 nm. The formulations had acceptable physicochemical properties with good drug-excipient compatibility. The antibacterial activity of cream formulations had a significantly (p<0.0001) higher antibacterial activity compared to ointment formulations. Both formulations with SNPs had higher antibacterial activity than ciprofloxacin. Conclusion. Cream and ointment formulations loaded with green synthesized E. cymosa leaf extract SNPs present a potential for a more efficient and effective antibacterial drug delivery to ameliorate the impact of antibacterial drug resistance. |
| format | Article |
| id | doaj-art-3190281198e64030b3ee9fbe5d704dce |
| institution | DOAJ |
| issn | 1687-9511 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nanotechnology |
| spelling | doaj-art-3190281198e64030b3ee9fbe5d704dce2025-08-20T03:18:39ZengWileyJournal of Nanotechnology1687-95112023-01-01202310.1155/2023/2808015Green Synthesis of Silver Nanoparticles Using Extracts of Ehretia cymosa and Evaluation of Its Antibacterial Activity in Cream and Ointment Drug Delivery SystemsOlutayo Ademola Adeleye0Olatunji Kayode Aremu1Haroon Iqbal2Musiliu Oluseun Adedokun3Oluyemisi Adebowale Bamiro4Olufemi Lionel Okunye5Mbang N. Femi-Oyewo6Kehinde Oluseun Sodeinde7Zwanden S. Yahaya8Adepero Olubukola Awolesi9Department of Pharmaceutics and Pharmaceutical TechnologyDepartment of MicrobiologyThe Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)Department of Pharmaceutics and Pharmaceutical TechnologyDepartment of Pharmaceutics and Pharmaceutical TechnologyDepartment of Pharmaceutical MicrobiologyDepartment of Pharmaceutics and Pharmaceutical TechnologyDepartment of ChemistryDepartment of Pharmaceutics and Industrial PharmacyDepartment of PharmacognosyObjectives. The use of antibacterial drugs for the treatment of infections has been on for several decades but not without some challenges such as resistance. Research on natural products is on-going to mitigate this challenge. The aim of this study was to synthesize silver nanoparticles (SNPs) with aqueous and methanol extract of Ehretia cymosa leaf and to explore its antibacterial potentials in semisolid dosage delivery system as topical antibacterial cream and ointment. Methods. E. cymosa leaf was extracted by macerating in distilled water and methanol. The extracts were used to synthesize SNPs. SNPs were characterized and confirmed by visual observation, UV-visible spectroscopy, FTIR, atomic absorption spectroscopy, scanning electron microscopy, and energy dispersive X-ray spectroscopy. SNPs were used to formulate cream and ointment, and the antibacterial activity of the formulations was evaluated against Staphylococcus aureus and Escherichia coli. Results. Absorption band was observed at 450 nm for aqueous extract SNPs and 420 nm for methanol extract SNPs due to surface plasmon resonance. SNPs were agglomerated with the irregular size of 55 nm and 90 nm. The formulations had acceptable physicochemical properties with good drug-excipient compatibility. The antibacterial activity of cream formulations had a significantly (p<0.0001) higher antibacterial activity compared to ointment formulations. Both formulations with SNPs had higher antibacterial activity than ciprofloxacin. Conclusion. Cream and ointment formulations loaded with green synthesized E. cymosa leaf extract SNPs present a potential for a more efficient and effective antibacterial drug delivery to ameliorate the impact of antibacterial drug resistance.http://dx.doi.org/10.1155/2023/2808015 |
| spellingShingle | Olutayo Ademola Adeleye Olatunji Kayode Aremu Haroon Iqbal Musiliu Oluseun Adedokun Oluyemisi Adebowale Bamiro Olufemi Lionel Okunye Mbang N. Femi-Oyewo Kehinde Oluseun Sodeinde Zwanden S. Yahaya Adepero Olubukola Awolesi Green Synthesis of Silver Nanoparticles Using Extracts of Ehretia cymosa and Evaluation of Its Antibacterial Activity in Cream and Ointment Drug Delivery Systems Journal of Nanotechnology |
| title | Green Synthesis of Silver Nanoparticles Using Extracts of Ehretia cymosa and Evaluation of Its Antibacterial Activity in Cream and Ointment Drug Delivery Systems |
| title_full | Green Synthesis of Silver Nanoparticles Using Extracts of Ehretia cymosa and Evaluation of Its Antibacterial Activity in Cream and Ointment Drug Delivery Systems |
| title_fullStr | Green Synthesis of Silver Nanoparticles Using Extracts of Ehretia cymosa and Evaluation of Its Antibacterial Activity in Cream and Ointment Drug Delivery Systems |
| title_full_unstemmed | Green Synthesis of Silver Nanoparticles Using Extracts of Ehretia cymosa and Evaluation of Its Antibacterial Activity in Cream and Ointment Drug Delivery Systems |
| title_short | Green Synthesis of Silver Nanoparticles Using Extracts of Ehretia cymosa and Evaluation of Its Antibacterial Activity in Cream and Ointment Drug Delivery Systems |
| title_sort | green synthesis of silver nanoparticles using extracts of ehretia cymosa and evaluation of its antibacterial activity in cream and ointment drug delivery systems |
| url | http://dx.doi.org/10.1155/2023/2808015 |
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