Slow Progression of Cognitive Dysfunction of Alzheimer’s Disease in Sexagenarian Women with Schizophrenia
Although both schizophrenia (SCZ) and Alzheimer’s disease (AD) are among the most common psychiatric diseases, the interaction of these two is not well-understood. We investigated three women with SCZ who developed AD in their 60s. The patients presented with cognitive dysfunction such as loss of re...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2015/968598 |
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| author | Kazuo Sakai Haruhiko Oda Akira Terashima Kazunari Ishii Kiyoshi Maeda |
| author_facet | Kazuo Sakai Haruhiko Oda Akira Terashima Kazunari Ishii Kiyoshi Maeda |
| author_sort | Kazuo Sakai |
| collection | DOAJ |
| description | Although both schizophrenia (SCZ) and Alzheimer’s disease (AD) are among the most common psychiatric diseases, the interaction of these two is not well-understood. We investigated three women with SCZ who developed AD in their 60s. The patients presented with cognitive dysfunction such as loss of recent memory, which was confirmed by both clinical observations and neuropsychological tests. Their magnetic resonance and functional imaging findings were consistent with AD. Their brain atrophy advanced significantly during a 6-year observation period. However, their global cognitive function did not deteriorate significantly during this period. Although the cognitive reserve model might account for this discrepancy, our results suggest some interactions between the neuropathology of SCZ and AD and warrant further research. |
| format | Article |
| id | doaj-art-318ecb3491b649e9a58f0a88dfebcdab |
| institution | Kabale University |
| issn | 2090-682X 2090-6838 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-318ecb3491b649e9a58f0a88dfebcdab2025-08-20T03:55:01ZengWileyCase Reports in Psychiatry2090-682X2090-68382015-01-01201510.1155/2015/968598968598Slow Progression of Cognitive Dysfunction of Alzheimer’s Disease in Sexagenarian Women with SchizophreniaKazuo Sakai0Haruhiko Oda1Akira Terashima2Kazunari Ishii3Kiyoshi Maeda4Department of Physical Therapy, Takarazuka University of Medical and Health Care, School of Health Science, 1 Hanayashiki-Midorigaoka, Takarazuka, Hyogo 666-0162, JapanDepartment of Physical Therapy, Takarazuka University of Medical and Health Care, School of Health Science, 1 Hanayashiki-Midorigaoka, Takarazuka, Hyogo 666-0162, JapanDepartment of Physical Therapy, Takarazuka University of Medical and Health Care, School of Health Science, 1 Hanayashiki-Midorigaoka, Takarazuka, Hyogo 666-0162, JapanDepartment of Physical Therapy, Takarazuka University of Medical and Health Care, School of Health Science, 1 Hanayashiki-Midorigaoka, Takarazuka, Hyogo 666-0162, JapanDepartment of Physical Therapy, Takarazuka University of Medical and Health Care, School of Health Science, 1 Hanayashiki-Midorigaoka, Takarazuka, Hyogo 666-0162, JapanAlthough both schizophrenia (SCZ) and Alzheimer’s disease (AD) are among the most common psychiatric diseases, the interaction of these two is not well-understood. We investigated three women with SCZ who developed AD in their 60s. The patients presented with cognitive dysfunction such as loss of recent memory, which was confirmed by both clinical observations and neuropsychological tests. Their magnetic resonance and functional imaging findings were consistent with AD. Their brain atrophy advanced significantly during a 6-year observation period. However, their global cognitive function did not deteriorate significantly during this period. Although the cognitive reserve model might account for this discrepancy, our results suggest some interactions between the neuropathology of SCZ and AD and warrant further research.http://dx.doi.org/10.1155/2015/968598 |
| spellingShingle | Kazuo Sakai Haruhiko Oda Akira Terashima Kazunari Ishii Kiyoshi Maeda Slow Progression of Cognitive Dysfunction of Alzheimer’s Disease in Sexagenarian Women with Schizophrenia Case Reports in Psychiatry |
| title | Slow Progression of Cognitive Dysfunction of Alzheimer’s Disease in Sexagenarian Women with Schizophrenia |
| title_full | Slow Progression of Cognitive Dysfunction of Alzheimer’s Disease in Sexagenarian Women with Schizophrenia |
| title_fullStr | Slow Progression of Cognitive Dysfunction of Alzheimer’s Disease in Sexagenarian Women with Schizophrenia |
| title_full_unstemmed | Slow Progression of Cognitive Dysfunction of Alzheimer’s Disease in Sexagenarian Women with Schizophrenia |
| title_short | Slow Progression of Cognitive Dysfunction of Alzheimer’s Disease in Sexagenarian Women with Schizophrenia |
| title_sort | slow progression of cognitive dysfunction of alzheimer s disease in sexagenarian women with schizophrenia |
| url | http://dx.doi.org/10.1155/2015/968598 |
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