The Impact of Short-Term Supplementation With Guanidinoacetic Acid and Creatine Versus Creatine Alone on Body Composition Indices in Healthy Men and Women: Creatine-Guanidinoacetic Acid Affects Body Composition
The main objective of this pilot study was to compare the effects of short-term supplementation with a mixture containing creatine and guanidinoacetic acid (GAA) versus creatine alone on body composition indices in men and women. Twenty-three apparently healthy young adults (mean age: 21.4 ± 0.6 yea...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2024/7815807 |
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| author | Sonja Baltic David Nedeljkovic Nikola Todorovic Laszlo Ratgeber Jozsef Betlehem Pongrac Acs Valdemar Stajer Sergej M. Ostojic |
| author_facet | Sonja Baltic David Nedeljkovic Nikola Todorovic Laszlo Ratgeber Jozsef Betlehem Pongrac Acs Valdemar Stajer Sergej M. Ostojic |
| author_sort | Sonja Baltic |
| collection | DOAJ |
| description | The main objective of this pilot study was to compare the effects of short-term supplementation with a mixture containing creatine and guanidinoacetic acid (GAA) versus creatine alone on body composition indices in men and women. Twenty-three apparently healthy young adults (mean age: 21.4 ± 0.6 years; 10 females) were randomly assigned to receive either a mixture (consisting of 2 g of creatine monohydrate and 2 g of GAA) or an equimolar amount of creatine monohydrate in a pretest–posttest control group experimental crossover design. After the intervention period, participants entered a 2-week washout phase to minimize any residual effects of the treatment. Body composition was assessed using a multifrequency bioelectrical impedance analysis at baseline (preadministration) and at the 7-day follow-up (postadministration). A significant interaction effect was found for extracellular mass (p=0.009), with creatine–GAA outperforming creatine in augmenting extracellular mass across the whole sample. In the male subsample, creatine was superior to the mixture in increasing intracellular water (p=0.049), whereas the mixture increased extracellular mass, contrasting with the reduction observed with creatine alone (p=0.008). No significant differences between interventions were reported in the female subsample (p>0.05), indicating that adding GAA to creatine may produce unique, sex-specific effects on body composition. Further studies are needed to validate our findings across different demographic cohorts and various interventional regimens. |
| format | Article |
| id | doaj-art-31889f8ced4c49d5b368ffd0ad04228a |
| institution | Kabale University |
| issn | 2090-0732 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-31889f8ced4c49d5b368ffd0ad04228a2025-02-03T05:32:40ZengWileyJournal of Nutrition and Metabolism2090-07322024-01-01202410.1155/2024/7815807The Impact of Short-Term Supplementation With Guanidinoacetic Acid and Creatine Versus Creatine Alone on Body Composition Indices in Healthy Men and Women: Creatine-Guanidinoacetic Acid Affects Body CompositionSonja Baltic0David Nedeljkovic1Nikola Todorovic2Laszlo Ratgeber3Jozsef Betlehem4Pongrac Acs5Valdemar Stajer6Sergej M. Ostojic7Applied Bioenergetics LabApplied Bioenergetics LabApplied Bioenergetics LabFaculty of Health SciencesFaculty of Health SciencesFaculty of Health SciencesApplied Bioenergetics LabApplied Bioenergetics LabThe main objective of this pilot study was to compare the effects of short-term supplementation with a mixture containing creatine and guanidinoacetic acid (GAA) versus creatine alone on body composition indices in men and women. Twenty-three apparently healthy young adults (mean age: 21.4 ± 0.6 years; 10 females) were randomly assigned to receive either a mixture (consisting of 2 g of creatine monohydrate and 2 g of GAA) or an equimolar amount of creatine monohydrate in a pretest–posttest control group experimental crossover design. After the intervention period, participants entered a 2-week washout phase to minimize any residual effects of the treatment. Body composition was assessed using a multifrequency bioelectrical impedance analysis at baseline (preadministration) and at the 7-day follow-up (postadministration). A significant interaction effect was found for extracellular mass (p=0.009), with creatine–GAA outperforming creatine in augmenting extracellular mass across the whole sample. In the male subsample, creatine was superior to the mixture in increasing intracellular water (p=0.049), whereas the mixture increased extracellular mass, contrasting with the reduction observed with creatine alone (p=0.008). No significant differences between interventions were reported in the female subsample (p>0.05), indicating that adding GAA to creatine may produce unique, sex-specific effects on body composition. Further studies are needed to validate our findings across different demographic cohorts and various interventional regimens.http://dx.doi.org/10.1155/2024/7815807 |
| spellingShingle | Sonja Baltic David Nedeljkovic Nikola Todorovic Laszlo Ratgeber Jozsef Betlehem Pongrac Acs Valdemar Stajer Sergej M. Ostojic The Impact of Short-Term Supplementation With Guanidinoacetic Acid and Creatine Versus Creatine Alone on Body Composition Indices in Healthy Men and Women: Creatine-Guanidinoacetic Acid Affects Body Composition Journal of Nutrition and Metabolism |
| title | The Impact of Short-Term Supplementation With Guanidinoacetic Acid and Creatine Versus Creatine Alone on Body Composition Indices in Healthy Men and Women: Creatine-Guanidinoacetic Acid Affects Body Composition |
| title_full | The Impact of Short-Term Supplementation With Guanidinoacetic Acid and Creatine Versus Creatine Alone on Body Composition Indices in Healthy Men and Women: Creatine-Guanidinoacetic Acid Affects Body Composition |
| title_fullStr | The Impact of Short-Term Supplementation With Guanidinoacetic Acid and Creatine Versus Creatine Alone on Body Composition Indices in Healthy Men and Women: Creatine-Guanidinoacetic Acid Affects Body Composition |
| title_full_unstemmed | The Impact of Short-Term Supplementation With Guanidinoacetic Acid and Creatine Versus Creatine Alone on Body Composition Indices in Healthy Men and Women: Creatine-Guanidinoacetic Acid Affects Body Composition |
| title_short | The Impact of Short-Term Supplementation With Guanidinoacetic Acid and Creatine Versus Creatine Alone on Body Composition Indices in Healthy Men and Women: Creatine-Guanidinoacetic Acid Affects Body Composition |
| title_sort | impact of short term supplementation with guanidinoacetic acid and creatine versus creatine alone on body composition indices in healthy men and women creatine guanidinoacetic acid affects body composition |
| url | http://dx.doi.org/10.1155/2024/7815807 |
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