Progress in understanding the role and mechanism of miRNAs in osteoporosis
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1544944/full |
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| author | Feifei Meng Feifei Meng Changwei Yang Na Li Huaxin Wang |
| author_facet | Feifei Meng Feifei Meng Changwei Yang Na Li Huaxin Wang |
| author_sort | Feifei Meng |
| collection | DOAJ |
| description | Please confirm that the below Frontiers AI generated Alt-Text is an accurate visual description of your Figure(s). These Figure Alt-text proposals won't replace your figure captions and will not be visible on your article. If you wish to make any changes, kindly provide the exact revised Alt-Text you would like to use, ensuring that the word-count remains at approximately 100 words for best accessibility results. Further information on Alt-Text can be found here.Osteoporosis is a systemic metabolic disorder characterized by compromised bone strength and increased fracture risk. Exosomes, extracellular vesicles measuring 40–160 nm in diameter, are critical mediators of intercellular communication. Among their bioactive components, microRNAs (miRNAs) have garnered attention for their role in the pathogenesis of Osteoporosis. Through complementary binding to the 3′ untranslated regions of target genes, miRNAs regulate key processes such as bone formation, bone resorption, angiogenesis, and bone immunity. This review provides a comprehensive summary of the regulatory roles and underlying mechanisms of miRNAs in osteoporosis, offering insights into potential therapeutic strategies. |
| format | Article |
| id | doaj-art-31881fcf567d40ddb4462cabecf99f81 |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-31881fcf567d40ddb4462cabecf99f812025-08-20T03:47:01ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-08-011610.3389/fendo.2025.15449441544944Progress in understanding the role and mechanism of miRNAs in osteoporosisFeifei Meng0Feifei Meng1Changwei Yang2Na Li3Huaxin Wang4Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaCollege of First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaShandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaShandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaShandong University of Traditional Chinese Medicine, Jinan, Shandong, ChinaPlease confirm that the below Frontiers AI generated Alt-Text is an accurate visual description of your Figure(s). These Figure Alt-text proposals won't replace your figure captions and will not be visible on your article. If you wish to make any changes, kindly provide the exact revised Alt-Text you would like to use, ensuring that the word-count remains at approximately 100 words for best accessibility results. Further information on Alt-Text can be found here.Osteoporosis is a systemic metabolic disorder characterized by compromised bone strength and increased fracture risk. Exosomes, extracellular vesicles measuring 40–160 nm in diameter, are critical mediators of intercellular communication. Among their bioactive components, microRNAs (miRNAs) have garnered attention for their role in the pathogenesis of Osteoporosis. Through complementary binding to the 3′ untranslated regions of target genes, miRNAs regulate key processes such as bone formation, bone resorption, angiogenesis, and bone immunity. This review provides a comprehensive summary of the regulatory roles and underlying mechanisms of miRNAs in osteoporosis, offering insights into potential therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fendo.2025.1544944/fullosteoporosisbone remodelingmiRNAsmechanismexosomes |
| spellingShingle | Feifei Meng Feifei Meng Changwei Yang Na Li Huaxin Wang Progress in understanding the role and mechanism of miRNAs in osteoporosis Frontiers in Endocrinology osteoporosis bone remodeling miRNAs mechanism exosomes |
| title | Progress in understanding the role and mechanism of miRNAs in osteoporosis |
| title_full | Progress in understanding the role and mechanism of miRNAs in osteoporosis |
| title_fullStr | Progress in understanding the role and mechanism of miRNAs in osteoporosis |
| title_full_unstemmed | Progress in understanding the role and mechanism of miRNAs in osteoporosis |
| title_short | Progress in understanding the role and mechanism of miRNAs in osteoporosis |
| title_sort | progress in understanding the role and mechanism of mirnas in osteoporosis |
| topic | osteoporosis bone remodeling miRNAs mechanism exosomes |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1544944/full |
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