Using genomic structural equation modeling to examine the genetic architecture of PTSD and life satisfaction phenotypes
Objective: Posttraumatic stress disorder (PTSD) and life satisfaction phenotypes are inversely related on a phenotypic level. Given these established relations, researchers have begun to examine possible shared genetic contributions to these outcomes, though the existing genetic literature is sparse...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | European Journal of Psychotraumatology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/20008066.2025.2463187 |
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| author | Shannon E. Cusack Anna W. Wright Peter B. Barr Emily Notari Kaitlin E. Bountress Ananda B. Amstadter |
| author_facet | Shannon E. Cusack Anna W. Wright Peter B. Barr Emily Notari Kaitlin E. Bountress Ananda B. Amstadter |
| author_sort | Shannon E. Cusack |
| collection | DOAJ |
| description | Objective: Posttraumatic stress disorder (PTSD) and life satisfaction phenotypes are inversely related on a phenotypic level. Given these established relations, researchers have begun to examine possible shared genetic contributions to these outcomes, though the existing genetic literature is sparse and examines these relations via univariate methods. We sought to examine the genetic architecture of PTSD and six life satisfaction and well-being phenotypes (i.e. subjective well-being, friend satisfaction, life satisfaction, family satisfaction, work satisfaction, and financial satisfaction) using a multivariate approach.Method: We used Genomic Structural Equation Modeling (gSEM) to analyze summary-level genetic data from large-scale GWAS of the European Ancestry.Results: Findings show that a two, correlated factors model fit the data best, in which PTSD and life satisfaction phenotypes load on separate but correlated factors.Conclusions: Findings suggest that, using multivariate methods, a latent factor capturing many different positive phenotypes is genetically related to PTSD. This finding confirms and extends prior phenotypic work demonstrating that PTSD and positive phenotypes are inversely related. |
| format | Article |
| id | doaj-art-31859498e47e45aaa9bea537af1ab9c8 |
| institution | DOAJ |
| issn | 2000-8066 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | European Journal of Psychotraumatology |
| spelling | doaj-art-31859498e47e45aaa9bea537af1ab9c82025-08-20T03:22:16ZengTaylor & Francis GroupEuropean Journal of Psychotraumatology2000-80662025-12-0116110.1080/20008066.2025.2463187Using genomic structural equation modeling to examine the genetic architecture of PTSD and life satisfaction phenotypesShannon E. Cusack0Anna W. Wright1Peter B. Barr2Emily Notari3Kaitlin E. Bountress4Ananda B. Amstadter5Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USADepartment of Psychiatry, Virginia Commonwealth University, Richmond, VA, USAInstitute for Genomics in Health, Psychiatry, State University of New York- Downstate, Brooklyn, NY, USASchool of Medicine, Virginia Commonwealth University, Richmond, VA, USAVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USAVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USAObjective: Posttraumatic stress disorder (PTSD) and life satisfaction phenotypes are inversely related on a phenotypic level. Given these established relations, researchers have begun to examine possible shared genetic contributions to these outcomes, though the existing genetic literature is sparse and examines these relations via univariate methods. We sought to examine the genetic architecture of PTSD and six life satisfaction and well-being phenotypes (i.e. subjective well-being, friend satisfaction, life satisfaction, family satisfaction, work satisfaction, and financial satisfaction) using a multivariate approach.Method: We used Genomic Structural Equation Modeling (gSEM) to analyze summary-level genetic data from large-scale GWAS of the European Ancestry.Results: Findings show that a two, correlated factors model fit the data best, in which PTSD and life satisfaction phenotypes load on separate but correlated factors.Conclusions: Findings suggest that, using multivariate methods, a latent factor capturing many different positive phenotypes is genetically related to PTSD. This finding confirms and extends prior phenotypic work demonstrating that PTSD and positive phenotypes are inversely related.https://www.tandfonline.com/doi/10.1080/20008066.2025.2463187Genomic structural equation modellingposttraumatic stress disorderlife satisfactiongeneticsModelado de ecuaciones estructurales genómicastrastorno de estrés postraumático |
| spellingShingle | Shannon E. Cusack Anna W. Wright Peter B. Barr Emily Notari Kaitlin E. Bountress Ananda B. Amstadter Using genomic structural equation modeling to examine the genetic architecture of PTSD and life satisfaction phenotypes European Journal of Psychotraumatology Genomic structural equation modelling posttraumatic stress disorder life satisfaction genetics Modelado de ecuaciones estructurales genómicas trastorno de estrés postraumático |
| title | Using genomic structural equation modeling to examine the genetic architecture of PTSD and life satisfaction phenotypes |
| title_full | Using genomic structural equation modeling to examine the genetic architecture of PTSD and life satisfaction phenotypes |
| title_fullStr | Using genomic structural equation modeling to examine the genetic architecture of PTSD and life satisfaction phenotypes |
| title_full_unstemmed | Using genomic structural equation modeling to examine the genetic architecture of PTSD and life satisfaction phenotypes |
| title_short | Using genomic structural equation modeling to examine the genetic architecture of PTSD and life satisfaction phenotypes |
| title_sort | using genomic structural equation modeling to examine the genetic architecture of ptsd and life satisfaction phenotypes |
| topic | Genomic structural equation modelling posttraumatic stress disorder life satisfaction genetics Modelado de ecuaciones estructurales genómicas trastorno de estrés postraumático |
| url | https://www.tandfonline.com/doi/10.1080/20008066.2025.2463187 |
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