<i>circSATB1</i> Modulates Cell Senescence in Age-Related Acute Myeloid Leukemia: A Mechanistic Proposal
Acute myeloid leukemia (AML) is a malignant hematological tumor with a high prevalence in elderly people, and circular RNA (circRNA) plays an important role in age-related diseases. Induction of cancer cell senescence is a highly promising therapeutic strategy; however, the presence of senescence-as...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-07-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/14/15/1181 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Acute myeloid leukemia (AML) is a malignant hematological tumor with a high prevalence in elderly people, and circular RNA (circRNA) plays an important role in age-related diseases. Induction of cancer cell senescence is a highly promising therapeutic strategy; however, the presence of senescence-associated circRNAs in AML remains to be elucidated. Here, we show that the expression patterns of circRNAs differed between elderly AML patients and healthy volunteers. <i>circSATB1</i> was significantly overexpressed in elderly patients and AML cells. Knockdown of <i>circSATB1</i> resulted in the inhibition of proliferation and arrest of the cell cycle in the G0/G1 phase; no effect on apoptosis or DNA integrity was observed, and precocious cellular senescence was promoted, characterized by no change in telomere length. Database analysis revealed that there may be two miRNA and nine RNA-binding proteins (RBPs) involved in regulating the cellular functions of <i>circSATB1</i>. Our observations uncover <i>circSATB1</i>-orchestrated cell senescence in AML, which provides clues for finding more modest therapeutic targets for AML. |
|---|---|
| ISSN: | 2073-4409 |