Interleukin-34 as a Robust Predictor of No-Reflow Phenomenon in ST-Elevation Myocardial Infarction: Insights into Inflammatory Mechanisms and Clinical Implications
Objective: ST-elevation myocardial infarction (STEMI) poses a significant challenge despite advances in reperfusion strategies. The “no-reflow” phenomenon, characterized by inadequate microvascular blood flow restoration following successful revascularization, remains poorly understood. Inflammation...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2024-10-01
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| Series: | Gazi Medical Journal |
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| Online Access: | https://gazimedj.com/articles/interleukin-34-as-a-robust-predictor-of-no-reflow-phenomenon-in-st-elevation-myocardial-infarction-insights-into-inflammatory-mechanisms-and-clinical-implications/doi/gmj.2024.4054 |
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| author | Mehdi Karasu Hasan Ata Bolayır İbrahim Aktaş |
| author_facet | Mehdi Karasu Hasan Ata Bolayır İbrahim Aktaş |
| author_sort | Mehdi Karasu |
| collection | DOAJ |
| description | Objective: ST-elevation myocardial infarction (STEMI) poses a significant challenge despite advances in reperfusion strategies. The “no-reflow” phenomenon, characterized by inadequate microvascular blood flow restoration following successful revascularization, remains poorly understood. Inflammation, particularly interleukin-34 (IL-34), is implicated in cardiovascular disease, prompting investigation into its role in no-reflow.
Methods: This observational study included 182 patients with STEMI (32 with no-reflow, 150 without) and 100 controls. Clinical and angiographic data were analyzed, and IL-34 levels were measured. Logistic regression and receiver operating characteristic (ROC) analysis assessed IL-34’s predictive value for no-reflow.
Results: Patients with no reflow exhibited elevated IL-34 levels compared with controls and those without no-reflow. Logistic regression identified IL-34 as an independent predictor of no-reflow (odds ratio: 1,020, p<0.001). ROC analysis showed IL-34’s significant predictive value (area under the curve: 0.972, p<0.001).
Conclusion: IL-34 emerges as a robust predictor of no-reflow in STEMI, potentially reflecting its role in macrophage activation and the inflammatory response. These findings suggest a novel avenue for understanding and mitigating no-reflow in STEMI, paving the way for targeted therapies. Early identification of high-risk patients could inform tailored interventions, ultimately improving STEMI outcomes. Further research is warranted to elucidate IL-34’s mechanistic involvement and validate its predictive value in larger cohorts. |
| format | Article |
| id | doaj-art-317776ce7cc8454a88cd693efe3d9fd6 |
| institution | Kabale University |
| issn | 2147-2092 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Gazi Medical Journal |
| spelling | doaj-art-317776ce7cc8454a88cd693efe3d9fd62025-01-16T10:41:29ZengGalenos Publishing HouseGazi Medical Journal2147-20922024-10-0135437638110.12996/gmj.2024.4054Interleukin-34 as a Robust Predictor of No-Reflow Phenomenon in ST-Elevation Myocardial Infarction: Insights into Inflammatory Mechanisms and Clinical ImplicationsMehdi Karasu0https://orcid.org/0000-0003-1713-3451Hasan Ata Bolayır1https://orcid.org/0000-0002-3557-1175İbrahim Aktaş2https://orcid.org/0000-0002-2982-8384Department of Cardiology, Elazığ Fethi Sekin City Hospital, TürkiyeDepartment of Cardiology, Malatya Turgut Özal University Faculty of Medicine, Malatya, TürkiyeDepartment of Cardiology, Malatya Turgut Özal University Faculty of Medicine, Malatya, TürkiyeObjective: ST-elevation myocardial infarction (STEMI) poses a significant challenge despite advances in reperfusion strategies. The “no-reflow” phenomenon, characterized by inadequate microvascular blood flow restoration following successful revascularization, remains poorly understood. Inflammation, particularly interleukin-34 (IL-34), is implicated in cardiovascular disease, prompting investigation into its role in no-reflow. Methods: This observational study included 182 patients with STEMI (32 with no-reflow, 150 without) and 100 controls. Clinical and angiographic data were analyzed, and IL-34 levels were measured. Logistic regression and receiver operating characteristic (ROC) analysis assessed IL-34’s predictive value for no-reflow. Results: Patients with no reflow exhibited elevated IL-34 levels compared with controls and those without no-reflow. Logistic regression identified IL-34 as an independent predictor of no-reflow (odds ratio: 1,020, p<0.001). ROC analysis showed IL-34’s significant predictive value (area under the curve: 0.972, p<0.001). Conclusion: IL-34 emerges as a robust predictor of no-reflow in STEMI, potentially reflecting its role in macrophage activation and the inflammatory response. These findings suggest a novel avenue for understanding and mitigating no-reflow in STEMI, paving the way for targeted therapies. Early identification of high-risk patients could inform tailored interventions, ultimately improving STEMI outcomes. Further research is warranted to elucidate IL-34’s mechanistic involvement and validate its predictive value in larger cohorts.https://gazimedj.com/articles/interleukin-34-as-a-robust-predictor-of-no-reflow-phenomenon-in-st-elevation-myocardial-infarction-insights-into-inflammatory-mechanisms-and-clinical-implications/doi/gmj.2024.4054interleukin-34st-elevation myocardial infarctionno-reflow phenomenon |
| spellingShingle | Mehdi Karasu Hasan Ata Bolayır İbrahim Aktaş Interleukin-34 as a Robust Predictor of No-Reflow Phenomenon in ST-Elevation Myocardial Infarction: Insights into Inflammatory Mechanisms and Clinical Implications Gazi Medical Journal interleukin-34 st-elevation myocardial infarction no-reflow phenomenon |
| title | Interleukin-34 as a Robust Predictor of No-Reflow Phenomenon in ST-Elevation Myocardial Infarction: Insights into Inflammatory Mechanisms and Clinical Implications |
| title_full | Interleukin-34 as a Robust Predictor of No-Reflow Phenomenon in ST-Elevation Myocardial Infarction: Insights into Inflammatory Mechanisms and Clinical Implications |
| title_fullStr | Interleukin-34 as a Robust Predictor of No-Reflow Phenomenon in ST-Elevation Myocardial Infarction: Insights into Inflammatory Mechanisms and Clinical Implications |
| title_full_unstemmed | Interleukin-34 as a Robust Predictor of No-Reflow Phenomenon in ST-Elevation Myocardial Infarction: Insights into Inflammatory Mechanisms and Clinical Implications |
| title_short | Interleukin-34 as a Robust Predictor of No-Reflow Phenomenon in ST-Elevation Myocardial Infarction: Insights into Inflammatory Mechanisms and Clinical Implications |
| title_sort | interleukin 34 as a robust predictor of no reflow phenomenon in st elevation myocardial infarction insights into inflammatory mechanisms and clinical implications |
| topic | interleukin-34 st-elevation myocardial infarction no-reflow phenomenon |
| url | https://gazimedj.com/articles/interleukin-34-as-a-robust-predictor-of-no-reflow-phenomenon-in-st-elevation-myocardial-infarction-insights-into-inflammatory-mechanisms-and-clinical-implications/doi/gmj.2024.4054 |
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