The median effective dose of ciprofol combined with a low-dose sufentanil for gastroscopy in obese or nonobese patients: a dose-finding study using Dixon’s up-and-down method

The median effective dose of ciprofol combined with a low-dose sufentanil for gastroscopy in obese or nonobese patients: a dose-finding study using Dixon’s up-and-down method

ObjectivesUnderstanding the different pharmacodynamic responses to narcotics in patients with or without obesity is particularly important for the safety of gastroscopy sedation. This study aimed to determine the median effective dose (ED50) of ciprofol combined with low-dose sufentanil to inhibit t...

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Bibliographic Details
Main Authors: Jie Zhao, Yixiao Zhang, Guowei Su, Shaoyi Wang, Xiaolin Zhang, Guoxiang Wang, Gang Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
ciprofol
patients with obesity
painless gastroscopy
sufentanil
dosage exploration
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1521715/full
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